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Gene · 2224

FDPS: farnesyl diphosphate synthase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FDPS: farnesyl diphosphate synthase. Genes, record 2224. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2224

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Gene

Symbol
FDPS
HGNC
Name
farnesyl diphosphate synthase
HGNC
NCBI Gene ID
2224
NCBI Gene
HGNC ID
HGNC:3631
HGNC
Ensembl
ENSG00000160752
NCBI Gene
Aliases
FPPS, FPS, POROK9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14324Farnesyl pyrophosphate synthase41992Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445861P14324Espacenet
JP 2026004568 A2026-01-1445862P14324Espacenet
EP 4650780 A22025-11-197328P14324Espacenet
EP 4641201 A22025-10-297276P14324Espacenet
EP 4641202 A22025-10-295255P14324Espacenet
US 12433933 B22025-10-071P14324Espacenet
US 12433933 B22025-10-0721P14324Espacenet
JP 2025517969 A2025-06-127276P14324Espacenet
JP 2025517970 A2025-06-127328P14324Espacenet
KR 1020250017231 A2025-02-045255P14324Espacenet

1 to 10 of 52

See all 52 patents

Drugs11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALENDRONATE SODIUMCHEMBL675Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
ALENDRONIC ACIDCHEMBL870Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
IBANDRONATE SODIUMCHEMBL3989569Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
IBANDRONIC ACIDCHEMBL997Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
MINODRONIC ACIDCHEMBL319144Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
PAMIDRONATE DISODIUMCHEMBL3989401Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
PAMIDRONIC ACIDCHEMBL834Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
RISEDRONATE SODIUMCHEMBL1654Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
RISEDRONIC ACIDCHEMBL923Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL
ZOLEDRONIC ACIDCHEMBL4303669Farnesyl diphosphate synthase inhibitorINHIBITORChEMBL

1 to 10 of 11

See all 11 drugs

Trials413

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07471880ALENDRONIC ACIDPHASE2ClinicalTrials.gov
NCT07471815RISEDRONATE SODIUMPHASE2ClinicalTrials.gov
NCT07471516ZOLEDRONIC ACIDPHASE1/PHASE2ClinicalTrials.gov
NCT07406685ZOLEDRONIC ACIDPHASE4ClinicalTrials.gov
NCT07406685IBANDRONIC ACIDPHASE4ClinicalTrials.gov
NCT07281586ZOLEDRONIC ACIDPHASE4ClinicalTrials.gov
NCT07242612ALENDRONIC ACIDClinicalTrials.gov
NCT07242612RISEDRONIC ACIDClinicalTrials.gov
NCT07242612IBANDRONIC ACIDClinicalTrials.gov
NCT07216794ALENDRONIC ACIDPHASE2ClinicalTrials.gov

1 to 10 of 413

See all 413 trials

NIH grants1,349

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFDPS papersNewest fiscal year
P30CA086862Cancer Center Support Grant122025
P30CA036727Buffett Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant72025
R01GM056838Structure and Function of Biosynthetic Enzymes62025
P01CA100730Retrovirus Models of Cancer52025
P30CA016086Cancer Center Support Grant52025
P30ES010126UNC Center for Environmental Health and Susceptibility52025
P30CA016672Cancer Center Support Grant42025
R01CA258621Geranylgeranyl diphosphate synthase inhibitor therapy for multiple myeloma42025
P30CA006973Regional Oncology Research Center32025

1 to 10 of 1,349Source NIH's project files

See all 1,349 nih grants

Papers2,695

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omics integration reveals tissue-specific biosynthesis of sesquiterpenoids in the medicinal plant Eupatorium lindleyanum.PLoS One202642821537PubTator, text miningPubMed
Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis.Drug Dev Res202642750477PubTator, text miningPubMed
An Investigation to Study Morphology, Nanomechanical Attributes, Transcriptomics, and Proteomics of Tumor Associated Macrophages Derived Extracellular Vesicles in the Tumor Microenvironment.J Anal Oncol202642719843PubTator, text miningPubMed
Postzygotic biallelic inactivation of FDFT1 underlies solitary lesion formation in porokeratosis of Mibelli.J Dermatol Sci202642716848PubTator, text miningPubMed
Β-Sitosterol-imidazolium ionic liquid conjugates: synthesis, computational evaluation, and anticancer activity against colorectal cancer cells.Steroids202642486216PubTator, text miningPubMed
Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.Am J Hum Genet202642392035PubTator, text miningPubMed
De Novo Transcriptomic Profiling of Piper chaba: Elucidating the Genetic Basis of Piperine Biosynthesis and Metabolic Pathways.Int J Genomics202642370307PubTator, text miningPubMed
The Effects of Bisphosphonates Used in Osteoporosis Treatment on Breast Cancer: Analysis with Integrative Bioinformatics Methods, DFT, ADMET and Molecular Docking Analysis.Biology (Basel)202642345808PubTator, text miningPubMed
A study to assess the levels of free protein S in pregnant and nonpregnant women in a tertiary care center in Western Maharashtra.Asian J Transfus Sci202642344662PubTator, text miningPubMed
Case Report: Zoledronic acid-induced hyperprogression in oncology: a case study of RET-driven neuroendocrine carcinoma treated with Selpercatinib.Front Oncol202642326324PubTator, text miningPubMed

1 to 10 of 2,695

See all 2,695 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2224

GET https://conductscience.org/api/genes/v1/2224/patents?page=2