Gene · 2692
GHRHR: growth hormone releasing hormone receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GHRHR: growth hormone releasing hormone receptor. Genes, record 2692. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2692
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q02643 | Growth hormone-releasing hormone receptor | 423 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 48352 | Q02643 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5952 | Q02643 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1705 | Q02643 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6493 | Q02643 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1705 | Q02643 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6493 | Q02643 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 5952 | Q02643 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 5952 | Q02643 | Espacenet |
| US 12168028 B2 | 2024-12-17 | 1 | Q02643 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 5959 | Q02643 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| SERMORELIN ACETATE | CHEMBL1201490 | Growth hormone-releasing hormone receptor agonist | AGONIST | ChEMBL |
| TESAMORELIN | CHEMBL1237026 | Growth hormone-releasing hormone receptor agonist | AGONIST | ChEMBL |
| TESAMORELIN ACETATE | CHEMBL2111290 | Growth hormone-releasing hormone receptor agonist | AGONIST | ChEMBL |
Trials12
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06554717 | TESAMORELIN | PHASE2 | ClinicalTrials.gov | |
| NCT03375788 | TESAMORELIN | PHASE2 | 2025-11-20 | ClinicalTrials.gov |
| NCT03150511 | TESAMORELIN | PHASE2 | ClinicalTrials.gov | |
| NCT02931474 | TESAMORELIN | PHASE2 | ClinicalTrials.gov | |
| NCT02196831 | TESAMORELIN | 2020-01-13 | ClinicalTrials.gov | |
| NCT02012556 | TESAMORELIN | PHASE1 | ClinicalTrials.gov | |
| NCT01788462 | TESAMORELIN | ClinicalTrials.gov | ||
| NCT01632592 | TESAMORELIN | ClinicalTrials.gov | ||
| NCT01388920 | TESAMORELIN | PHASE2 | 2014-05-07 | ClinicalTrials.gov |
| NCT01264497 | TESAMORELIN | PHASE2 | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsNIH grants411
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GHRHR papers | Newest fiscal year |
|---|---|---|---|
| P20GM103424 | Louisiana Biomedical Research Network | 9 | 2025 |
| ZIAHD000195 | Intracellular Signaling In Endocrine Cells | 3 | 2025 |
| P30AG013319 | San Antonio Nathan Shock Center of Excellence in the Biology of Aging | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 2 | 2025 |
| R01AG059779 | Combining GHR antagonism with life extending compounds: a search for synergies | 2 | 2025 |
| R01GM129325 | ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling | 2 | 2025 |
| ZIAHD000640 | Regulation Of Childhood Growth | 2 | 2025 |
| I01BX002728 | mTOR signaling and regulation of alpha-cell mass and function | 1 | 2025 |
| KL2TR001879 | Institutional Career Development Core | 1 | 2025 |
1 to 10 of 411Source NIH's project files
See all 411 nih grantsPapers921
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Lifelong congenital untreated isolated GH deficiency does not alter human leukocyte telomere length. | J Endocrinol Invest | 2026 | 42622938 | PubTator, text mining | PubMed |
| Effects of Dietary Sulphur Amino Acid Levels on Growth Performance, Meat Quality, Nutrient Digestibility, Serum Biochemistry and Feather Follicle Transcriptomics in Jiangnan White Goslings. | Animals (Basel) | 2026 | 42353475 | PubTator, text mining | PubMed |
| Pituitary developmental gene defects and their contribution to growth hormone deficiency. | Ann Endocrinol (Paris) | 2026 | 42250720 | PubTator, text mining | PubMed |
| Phenotypic and genotypic analysis of pediatric patients with congenital isolated growth hormone deficiency resulting from biallelic variants in the GHRHR gene: a Belgian registry study. | Eur J Pediatr | 2026 | 42143199 | PubTator, text mining | PubMed |
| Mesenchymal Stem cell therapy with GHRH receptor analog resolves post-stroke vasogenic edema via modulating AQP4 and mitochondria-ER crosstalk. | J Transl Med | 2026 | 42063069 | PubTator, text mining | PubMed |
| Unraveling the Genetic Heterogeneity of Isolated Growth Hormone Deficiency: Insights from the GENHYPOPIT Cohort. | Horm Res Paediatr | 2026 | 42054264 | PubTator, text mining | PubMed |
| GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis. | Adv Sci (Weinh) | 2026 | 41849678 | PubTator, text mining | PubMed |
| Structural adaptation associated with signaling preference at the human Growth Hormone-Releasing Hormone Receptor. | Protein Cell | 2026 | 41849435 | PubTator, text mining | PubMed |
| Growth hormone-releasing hormone in retinal disorders and uveitis: an updated review. | Int J Ophthalmol | 2026 | 41767328 | PubTator, text mining | PubMed |
| Identification and Functional Validation of PTH2R as a Therapeutic Target in Lung Adenocarcinoma. | Biomedicines | 2026 | 41751388 | PubTator, text mining | PubMed |
1 to 10 of 921
See all 921 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2692
GET https://conductscience.org/api/genes/v1/2692/patents?page=2