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Gene · 2692

GHRHR: growth hormone releasing hormone receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GHRHR: growth hormone releasing hormone receptor. Genes, record 2692. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2692

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Gene

Symbol
GHRHR
HGNC
Name
growth hormone releasing hormone receptor
HGNC
NCBI Gene ID
2692
NCBI Gene
HGNC ID
HGNC:4266
HGNC
Ensembl
ENSG00000106128
NCBI Gene
Aliases
GHRFR, GRFR, IGHD1B, IGHD4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02643Growth hormone-releasing hormone receptor4234Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448352Q02643Espacenet
JP 2025147176 A2025-10-065952Q02643Espacenet
JP 2025529142 A2025-09-041705Q02643Espacenet
JP 2025529142 A2025-09-046493Q02643Espacenet
US 12371689 B22025-07-291705Q02643Espacenet
US 12371689 B22025-07-296493Q02643Espacenet
JP 2025028160 A2025-02-285952Q02643Espacenet
KR 1020250010750 A2025-01-215952Q02643Espacenet
US 12168028 B22024-12-171Q02643Espacenet
JP 2024109657 A2024-08-145959Q02643Espacenet

1 to 10 of 38

See all 38 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SERMORELIN ACETATECHEMBL1201490Growth hormone-releasing hormone receptor agonistAGONISTChEMBL
TESAMORELINCHEMBL1237026Growth hormone-releasing hormone receptor agonistAGONISTChEMBL
TESAMORELIN ACETATECHEMBL2111290Growth hormone-releasing hormone receptor agonistAGONISTChEMBL

Trials12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06554717TESAMORELINPHASE2ClinicalTrials.gov
NCT03375788TESAMORELINPHASE22025-11-20ClinicalTrials.gov
NCT03150511TESAMORELINPHASE2ClinicalTrials.gov
NCT02931474TESAMORELINPHASE2ClinicalTrials.gov
NCT02196831TESAMORELIN2020-01-13ClinicalTrials.gov
NCT02012556TESAMORELINPHASE1ClinicalTrials.gov
NCT01788462TESAMORELINClinicalTrials.gov
NCT01632592TESAMORELINClinicalTrials.gov
NCT01388920TESAMORELINPHASE22014-05-07ClinicalTrials.gov
NCT01264497TESAMORELINPHASE2ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

NIH grants411

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGHRHR papersNewest fiscal year
P20GM103424Louisiana Biomedical Research Network92025
ZIAHD000195Intracellular Signaling In Endocrine Cells32025
P30AG013319San Antonio Nathan Shock Center of Excellence in the Biology of Aging22025
P30CA008748Cancer Center Support Grant22025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)22025
R01AG059779Combining GHR antagonism with life extending compounds: a search for synergies22025
R01GM129325ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling22025
ZIAHD000640Regulation Of Childhood Growth22025
I01BX002728mTOR signaling and regulation of alpha-cell mass and function12025
KL2TR001879Institutional Career Development Core12025

1 to 10 of 411Source NIH's project files

See all 411 nih grants

Papers921

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lifelong congenital untreated isolated GH deficiency does not alter human leukocyte telomere length.J Endocrinol Invest202642622938PubTator, text miningPubMed
Effects of Dietary Sulphur Amino Acid Levels on Growth Performance, Meat Quality, Nutrient Digestibility, Serum Biochemistry and Feather Follicle Transcriptomics in Jiangnan White Goslings.Animals (Basel)202642353475PubTator, text miningPubMed
Pituitary developmental gene defects and their contribution to growth hormone deficiency.Ann Endocrinol (Paris)202642250720PubTator, text miningPubMed
Phenotypic and genotypic analysis of pediatric patients with congenital isolated growth hormone deficiency resulting from biallelic variants in the GHRHR gene: a Belgian registry study.Eur J Pediatr202642143199PubTator, text miningPubMed
Mesenchymal Stem cell therapy with GHRH receptor analog resolves post-stroke vasogenic edema via modulating AQP4 and mitochondria-ER crosstalk.J Transl Med202642063069PubTator, text miningPubMed
Unraveling the Genetic Heterogeneity of Isolated Growth Hormone Deficiency: Insights from the GENHYPOPIT Cohort.Horm Res Paediatr202642054264PubTator, text miningPubMed
GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis.Adv Sci (Weinh)202641849678PubTator, text miningPubMed
Structural adaptation associated with signaling preference at the human Growth Hormone-Releasing Hormone Receptor.Protein Cell202641849435PubTator, text miningPubMed
Growth hormone-releasing hormone in retinal disorders and uveitis: an updated review.Int J Ophthalmol202641767328PubTator, text miningPubMed
Identification and Functional Validation of PTH2R as a Therapeutic Target in Lung Adenocarcinoma.Biomedicines202641751388PubTator, text miningPubMed

1 to 10 of 921

See all 921 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2692

GET https://conductscience.org/api/genes/v1/2692/patents?page=2