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Gene · 2693

GHSR: growth hormone secretagogue receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GHSR: growth hormone secretagogue receptor. Genes, record 2693. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2693

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Gene

Symbol
GHSR
HGNC
Name
growth hormone secretagogue receptor
HGNC
NCBI Gene ID
2693
NCBI Gene
HGNC ID
HGNC:4267
HGNC
Ensembl
ENSG00000121853
NCBI Gene
Aliases
GHDP, GHS-R, GHS-R1a, GHSR-1a
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92847Growth hormone secretagogue receptor type 136610Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448357Q92847Espacenet
EP 4641201 A22025-10-29727Q92847Espacenet
JP 2025529142 A2025-09-041706Q92847Espacenet
US 12371689 B22025-07-291706Q92847Espacenet
JP 2025517969 A2025-06-12727Q92847Espacenet
US 11548942 B22023-01-105Q92847Espacenet
US 11446398 B22022-09-2036532Q92847Espacenet
US 11400116 B22022-08-026794Q92847Espacenet
JP 2022524081 A2022-04-27139503Q92847Espacenet
US 10781253 B22020-09-225Q92847Espacenet

1 to 10 of 47

See all 47 patents

Drugs13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANAMORELINCHEMBL2110579Ghrelin receptor agonistAGONISTChEMBL
ANAMORELIN HYDROCHLORIDECHEMBL2103794Ghrelin receptor agonistAGONISTChEMBL
CAPROMORELINCHEMBL113313Ghrelin receptor agonistAGONISTChEMBL
IBUTAMORENCHEMBL13817Ghrelin receptor agonistAGONISTChEMBL
IBUTAMOREN MESYLATECHEMBL2105872Ghrelin receptor agonistAGONISTChEMBL
MACIMORELINCHEMBL278623Ghrelin receptor agonistAGONISTChEMBL
MACIMORELIN ACETATECHEMBL2364617Ghrelin receptor agonistAGONISTChEMBL
PF-5190457CHEMBL3287218Ghrelin receptor inverse agonistINVERSE AGONISTChEMBL
RELAMORELINCHEMBL4297525Ghrelin receptor agonistAGONISTChEMBL
TABIMORELINCHEMBL281764Ghrelin receptor agonistAGONISTChEMBL

1 to 10 of 13

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Trials31

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05364684IBUTAMORENPHASE22026-01-06ClinicalTrials.gov
NCT04844970ANAMORELIN HYDROCHLORIDEPHASE22025-11-17ClinicalTrials.gov
NCT03743064ANAMORELINPHASE32024-06-26ClinicalTrials.gov
NCT03743051ANAMORELINPHASE32024-06-26ClinicalTrials.gov
NCT03637816ANAMORELIN HYDROCHLORIDEPHASE2/PHASE3ClinicalTrials.gov
NCT03426345RELAMORELINPHASE32021-08-06ClinicalTrials.gov
NCT03420781RELAMORELINPHASE32021-12-22ClinicalTrials.gov
NCT03285308RELAMORELINPHASE32021-07-29ClinicalTrials.gov
NCT02357420RELAMORELINPHASE22019-07-24ClinicalTrials.gov
NCT02137642RELAMORELINPHASE1ClinicalTrials.gov

1 to 10 of 31

See all 31 trials

NIH grants1,393

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGHSR papersNewest fiscal year
ZIADA000635Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)142025
I01BX002807The Role of Ghrelin and the GHSR-1a receptor in Sarcopenic Obesity82025
P30DK017047Diabetes Research Center82025
P30CA008748Cancer Center Support Grant72025
P30CA056036Translational Research in Cancer52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30DK035816Nutrition Obesity Research Center52025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)52025
P30DK020593Vanderbilt Diabetes Research Center42025
P30DK026687New York Obesity Research Center42025

1 to 10 of 1,393Source NIH's project files

See all 1,393 nih grants

Papers3,015

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pancreatic Cancer Cachexia: Integrating Mechanistic Insights With Clinical Management.JCO Oncol Pract202642826357PubTator, text miningPubMed
Therapeutic modulation of the gut-brain axis in alcohol use disorder: A systematic review.Metabol Open202642750798PubTator, text miningPubMed
Cancer Cachexia Research and Drug Development: Lessons from Failures and the Promise of Immunomodulation.Cancers (Basel)202642738261PubTator, text miningPubMed
Experiences and Behavior During a Virtual Reality Buffet Simulation: A Secondary Analysis of a Ghrelin-Related Pharmacology Randomized Controlled Trial in People with Alcohol Use Disorder.J Med Ext Real202642724156PubTator, text miningPubMed
Exploring Inhibitory Impacts of Anamorelin on Colorectal Cancer Proliferation via Regulation of Transketolase.Curr Med Chem202642693844PubTator, text miningPubMed
Periodontitis and Mechanical Forces Modulate Ghrelin Receptor in Periodontal Tissues.APMIS202642692551PubTator, text miningPubMed
Meta-inflammation through the lens of macrophage programming and nutrient-sensing ghrelin signaling.Immunometabolism (Cobham)202642565088PubTator, text miningPubMed
Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short-Term Spatial Memory via Multiple Ionic and Signaling Mechanisms.Adv Biol (Weinh)202642552604PubTator, text miningPubMed
Predictors of early discontinuation and therapeutic response to anamorelin in patients with cancer cachexia: A retrospective study.Int J Clin Pharmacol Ther202642544527PubTator, text miningPubMed
A Prospective Observational Study of Anamorelin During Chemoimmunotherapy in Non-Small Cell Lung Cancer With Cachexia (SPIRAL-ANA).J Cachexia Sarcopenia Muscle202642411631PubTator, text miningPubMed

1 to 10 of 3,015

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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