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Gene · 2893

GRIA4: glutamate ionotropic receptor AMPA type subunit 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRIA4: glutamate ionotropic receptor AMPA type subunit 4. Genes, record 2893. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2893

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Gene

Symbol
GRIA4
HGNC
Name
glutamate ionotropic receptor AMPA type subunit 4
HGNC
NCBI Gene ID
2893
NCBI Gene
HGNC ID
HGNC:4574
HGNC
Ensembl
ENSG00000152578
NCBI Gene
Aliases
GLUR4, GLUR4C, GLURD, GluA4, GluA4-ATD, GluR-4, GluR-D, NEDSGA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48058Glutamate receptor 49020Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447710P48058Espacenet
JP 2026004568 A2026-01-1447717P48058Espacenet
EP 4650780 A22025-11-193167P48058Espacenet
EP 4641201 A22025-10-292729P48058Espacenet
JP 2025147176 A2025-10-066216P48058Espacenet
JP 2025147176 A2025-10-066220P48058Espacenet
JP 2025529142 A2025-09-041866P48058Espacenet
JP 2025529142 A2025-09-046545P48058Espacenet
US 12371689 B22025-07-291866P48058Espacenet
US 12371689 B22025-07-296545P48058Espacenet

1 to 10 of 42

See all 42 patents

Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BECAMPANELCHEMBL3989682Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
CX1739CHEMBL3707399Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
DASOLAMPANELCHEMBL2103869Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
FARAMPATORCHEMBL1276138Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
IRAMPANELCHEMBL29741Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
MIBAMPATORCHEMBL1277001Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
MK-8777CHEMBL3707401Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
OSAVAMPATORCHEMBL4594403Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
PERAMPANELCHEMBL1214124Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
PESAMPATORCHEMBL5095022Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 15

See all 15 drugs

Trials231

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07384624TOPIRAMATEPHASE1/PHASE2ClinicalTrials.gov
NCT07284069PERAMPANELEARLY_PHASE1ClinicalTrials.gov
NCT06347497TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06299891TOPIRAMATEPHASE2ClinicalTrials.gov
NCT06248931TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06243692TOPIRAMATEPHASE3ClinicalTrials.gov
NCT05958160TOPIRAMATEPHASE2/PHASE3ClinicalTrials.gov
NCT05915013PERAMPANELPHASE1ClinicalTrials.gov
NCT05786066PERAMPANELPHASE2ClinicalTrials.gov

1 to 10 of 231

See all 231 trials

NIH grants1,275

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRIA4 papersNewest fiscal year
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect62025
R01DC013048Mechanisms of hypersensitivity to sound-induced cochlear damage52025
R01NS031348Genetic Determinants of Epilepsy in Murine Systems52025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).52025
P30AG066507Johns Hopkins Alzheimer's Disease Research Center42025
R28AA012725Brain Tissue Resource Center for Alcohol Research42025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders42025
R01AG070255Mechanisms of Synaptic Protection in Cognitive Resilence to Alzheimer's Disease Neuropathology32025
R01EY012141Function of basal synapses at mammalian photoreceptors32025
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States32025

1 to 10 of 1,275Source NIH's project files

See all 1,275 nih grants

Papers1,572

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AMPAR Subunit Gene Expression Marks a Synaptic Transcriptional State in Lower-Grade Glioma.Brain Sci202642651084PubTator, text miningPubMed
Distinct roles of AMPA receptor subunits as potential therapeutic targets in Alzheimer's disease.Pharmacol Res202642595198PubTator, text miningPubMed
Taurine ameliorates damages induced by acute heat stress on porcine Sertoli cells.Theriogenology202642497608PubTator, text miningPubMed
Genomic Disruption of CAMKMT by t(2;11)(p21;q23) Reveals a Glycolytic Reprogramming Mechanism in Acute Myeloid Leukemia.Curr Med Chem202642474015PubTator, text miningPubMed
Screening of core targets for Di(2-ethylhexyl) Phthalate-related gastric cancer based on machine learning, molecular docking, and SHAP analysis.PLoS Comput Biol202642461936PubTator, text miningPubMed
Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults.Front Aging Neurosci202642376002PubTator, text miningPubMed
Differential DNA Methylation of the Serotonin Receptor Signaling and Glutamatergic Synapse Pathways in Adult Twins Born Preterm.Genes (Basel)202642353841PubTator, text miningPubMed
Subgroup-Specific Associations of GRIA Genes Encoding AMPA Glutamate Receptor Subunits with Patient Survival in Medulloblastoma.Neuromolecular Med202642277445PubTator, text miningPubMed
Integrative machine learning reveals interplay between epithelial and endothelial cells elevates mixed heavy metal-related colorectal cancer risk.J Biomed Res202642178188PubTator, text miningPubMed
Network pharmacology and molecular docking of arctic Pseudogymnoascus australis compounds targeting ionotropic glutamate receptors for neuroprotection.Comput Biol Chem202642160907PubTator, text miningPubMed

1 to 10 of 1,572

See all 1,572 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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