Gene · 2893
GRIA4: glutamate ionotropic receptor AMPA type subunit 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GRIA4: glutamate ionotropic receptor AMPA type subunit 4. Genes, record 2893. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2893
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48058 | Glutamate receptor 4 | 902 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47710 | P48058 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47717 | P48058 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3167 | P48058 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2729 | P48058 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6216 | P48058 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6220 | P48058 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1866 | P48058 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6545 | P48058 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1866 | P48058 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6545 | P48058 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs15
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BECAMPANEL | CHEMBL3989682 | Glutamate receptor ionotropic AMPA antagonist | ANTAGONIST | ChEMBL |
| CX1739 | CHEMBL3707399 | Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| DASOLAMPANEL | CHEMBL2103869 | Glutamate receptor ionotropic AMPA antagonist | ANTAGONIST | ChEMBL |
| FARAMPATOR | CHEMBL1276138 | Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| IRAMPANEL | CHEMBL29741 | Glutamate receptor ionotropic AMPA antagonist | ANTAGONIST | ChEMBL |
| MIBAMPATOR | CHEMBL1277001 | Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| MK-8777 | CHEMBL3707401 | Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| OSAVAMPATOR | CHEMBL4594403 | Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| PERAMPANEL | CHEMBL1214124 | Glutamate receptor ionotropic AMPA antagonist | ANTAGONIST | ChEMBL |
| PESAMPATOR | CHEMBL5095022 | Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 15
See all 15 drugsTrials231
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07384624 | TOPIRAMATE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07284069 | PERAMPANEL | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT06347497 | TOPIRAMATE | PHASE3 | ClinicalTrials.gov | |
| NCT06299891 | TOPIRAMATE | PHASE2 | ClinicalTrials.gov | |
| NCT06248931 | TOPIRAMATE | PHASE3 | ClinicalTrials.gov | |
| NCT06243692 | TOPIRAMATE | PHASE3 | ClinicalTrials.gov | |
| NCT05958160 | TOPIRAMATE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT05915013 | PERAMPANEL | PHASE1 | ClinicalTrials.gov | |
| NCT05786066 | PERAMPANEL | PHASE2 | ClinicalTrials.gov |
1 to 10 of 231
See all 231 trialsNIH grants1,275
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GRIA4 papers | Newest fiscal year |
|---|---|---|---|
| ZIAMH002857 | Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect | 6 | 2025 |
| R01DC013048 | Mechanisms of hypersensitivity to sound-induced cochlear damage | 5 | 2025 |
| R01NS031348 | Genetic Determinants of Epilepsy in Murine Systems | 5 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 5 | 2025 |
| P30AG066507 | Johns Hopkins Alzheimer's Disease Research Center | 4 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 4 | 2025 |
| ZIAMH002927 | Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders | 4 | 2025 |
| R01AG070255 | Mechanisms of Synaptic Protection in Cognitive Resilence to Alzheimer's Disease Neuropathology | 3 | 2025 |
| R01EY012141 | Function of basal synapses at mammalian photoreceptors | 3 | 2025 |
| R01NS107253 | Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States | 3 | 2025 |
1 to 10 of 1,275Source NIH's project files
See all 1,275 nih grantsPapers1,572
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| AMPAR Subunit Gene Expression Marks a Synaptic Transcriptional State in Lower-Grade Glioma. | Brain Sci | 2026 | 42651084 | PubTator, text mining | PubMed |
| Distinct roles of AMPA receptor subunits as potential therapeutic targets in Alzheimer's disease. | Pharmacol Res | 2026 | 42595198 | PubTator, text mining | PubMed |
| Taurine ameliorates damages induced by acute heat stress on porcine Sertoli cells. | Theriogenology | 2026 | 42497608 | PubTator, text mining | PubMed |
| Genomic Disruption of CAMKMT by t(2;11)(p21;q23) Reveals a Glycolytic Reprogramming Mechanism in Acute Myeloid Leukemia. | Curr Med Chem | 2026 | 42474015 | PubTator, text mining | PubMed |
| Screening of core targets for Di(2-ethylhexyl) Phthalate-related gastric cancer based on machine learning, molecular docking, and SHAP analysis. | PLoS Comput Biol | 2026 | 42461936 | PubTator, text mining | PubMed |
| Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults. | Front Aging Neurosci | 2026 | 42376002 | PubTator, text mining | PubMed |
| Differential DNA Methylation of the Serotonin Receptor Signaling and Glutamatergic Synapse Pathways in Adult Twins Born Preterm. | Genes (Basel) | 2026 | 42353841 | PubTator, text mining | PubMed |
| Subgroup-Specific Associations of GRIA Genes Encoding AMPA Glutamate Receptor Subunits with Patient Survival in Medulloblastoma. | Neuromolecular Med | 2026 | 42277445 | PubTator, text mining | PubMed |
| Integrative machine learning reveals interplay between epithelial and endothelial cells elevates mixed heavy metal-related colorectal cancer risk. | J Biomed Res | 2026 | 42178188 | PubTator, text mining | PubMed |
| Network pharmacology and molecular docking of arctic Pseudogymnoascus australis compounds targeting ionotropic glutamate receptors for neuroprotection. | Comput Biol Chem | 2026 | 42160907 | PubTator, text mining | PubMed |
1 to 10 of 1,572
See all 1,572 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2893
GET https://conductscience.org/api/genes/v1/2893/patents?page=2