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Gene · 2898

GRIK2: glutamate ionotropic receptor kainate type subunit 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRIK2: glutamate ionotropic receptor kainate type subunit 2. Genes, record 2898. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2898

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Gene

Symbol
GRIK2
HGNC
Name
glutamate ionotropic receptor kainate type subunit 2
HGNC
NCBI Gene ID
2898
NCBI Gene
HGNC ID
HGNC:4580
HGNC
Ensembl
ENSG00000164418
NCBI Gene
Aliases
EAA4, GLR6, GLUK6, GLUR6, GluK2, GluR-6, MRT6, NEDLAS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13002Glutamate receptor ionotropic, kainate 29082Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447757Q13002Espacenet
EP 4641201 A22025-10-2914292Q13002Espacenet
JP 2025147176 A2025-10-066231Q13002Espacenet
JP 2025529142 A2025-09-041870Q13002Espacenet
JP 2025529142 A2025-09-046546Q13002Espacenet
US 12371689 B22025-07-291870Q13002Espacenet
US 12371689 B22025-07-296546Q13002Espacenet
JP 2025517969 A2025-06-1214292Q13002Espacenet
JP 2025032204 A2025-03-1129334Q13002Espacenet
JP 2025028160 A2025-02-286231Q13002Espacenet

1 to 10 of 55

See all 55 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SELURAMPANELCHEMBL3545042Glutamate receptor ionotropic kainate antagonistANTAGONISTChEMBL
TEZAMPANELCHEMBL3989703Glutamate receptor ionotropic kainate antagonistANTAGONISTChEMBL
TEZAMPANEL ANHYDROUSCHEMBL14935Glutamate receptor ionotropic kainate antagonistANTAGONISTChEMBL
TOPIRAMATECHEMBL220492Glutamate receptor ionotropic kainate antagonistANTAGONISTChEMBL

Trials161

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07384624TOPIRAMATEPHASE1/PHASE2ClinicalTrials.gov
NCT06347497TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06299891TOPIRAMATEPHASE2ClinicalTrials.gov
NCT06248931TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06243692TOPIRAMATEPHASE3ClinicalTrials.gov
NCT05958160TOPIRAMATEPHASE2/PHASE3ClinicalTrials.gov
NCT05756764TOPIRAMATEClinicalTrials.gov
NCT05748483TOPIRAMATEPHASE3ClinicalTrials.gov
NCT05403229TOPIRAMATEPHASE2ClinicalTrials.gov

1 to 10 of 161

See all 161 trials

NIH grants1,337

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRIK2 papersNewest fiscal year
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect82025
R01CA206573Structure and function of Transient Receptor Potential Channels72025
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States72025
R35GM122528Dynamics Of Ligand Gated Ion Channels52025
ZIAMH002844Genetic Determinants of Antidepressant Response52025
R01AR078814Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.42025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders42025
P30CA016672Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025

1 to 10 of 1,337Source NIH's project files

See all 1,337 nih grants

Papers1,523

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Design and Evaluation of Selective Positive Allosteric Modulators Targeting Kainate Receptors.ACS Omega202642798915PubTator, text miningPubMed
Recovery of Dysarthria in Anti-GluK2 Antibody-Associated Autoimmune Cerebellar Ataxia: A Longitudinal Acoustic and Perceptual Case Report.Folia Phoniatr Logop202642789473PubTator, text miningPubMed
Cryo-EM structures of apo, agonist- and antagonist-bound heteromeric kainate receptors.Sci Adv202642536757PubTator, text miningPubMed
Glutamate Ionotropic Kainate Receptors as Therapeutic Targets in Enzalutamide-Resistant and Neuroendocrine Prostate Cancer.Int J Mol Sci202642450213PubTator, text miningPubMed
GRIK2 drives LUAD progression via the cAMP/PKA/CREB pathway.Tissue Cell202642184490PubTator, text miningPubMed
Network pharmacology and molecular docking of arctic Pseudogymnoascus australis compounds targeting ionotropic glutamate receptors for neuroprotection.Comput Biol Chem202642160907PubTator, text miningPubMed
Mapping the multi-domain allosteric network for CKAMP44 modulation of AMPA receptors.J Biol Chem202642107640PubTator, text miningPubMed
Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization.Nat Commun202642031800PubTator, text miningPubMed
Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.Nat Commun202641917044PubTator, text miningPubMed
Coexistence of anti-GluK2 and anti-LGI1 antibodies in a patient with autoimmune encephalitis: a rare case report and literature review.BMC Neurol202641913114PubTator, text miningPubMed

1 to 10 of 1,523

See all 1,523 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2898

GET https://conductscience.org/api/genes/v1/2898/patents?page=2