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Gene · 2912

GRM2: glutamate metabotropic receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRM2: glutamate metabotropic receptor 2. Genes, record 2912. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2912

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Gene

Symbol
GRM2
HGNC
Name
glutamate metabotropic receptor 2
HGNC
NCBI Gene ID
2912
NCBI Gene
HGNC ID
HGNC:4594
HGNC
Ensembl
ENSG00000164082
NCBI Gene
Aliases
GLUR2, GPRC1B, MGLUR2, mGlu2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14416Metabotropic glutamate receptor 287231Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12545895 B22026-02-1010Q14416Espacenet
JP 2026004568 A2026-01-1447792Q14416Espacenet
EP 4650780 A22025-11-1911221Q14416Espacenet
JP 2025147176 A2025-10-066238Q14416Espacenet
JP 2025529142 A2025-09-041883Q14416Espacenet
JP 2025529142 A2025-09-046548Q14416Espacenet
US 12371689 B22025-07-291883Q14416Espacenet
US 12371689 B22025-07-296548Q14416Espacenet
JP 2025517970 A2025-06-1211221Q14416Espacenet
JP 2025028160 A2025-02-286238Q14416Espacenet

1 to 10 of 32

See all 32 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DECOGLURANTCHEMBL3301593Metabotropic glutamate receptor 2 modulatorMODULATORChEMBL
JNJ-40411813CHEMBL3337527Metabotropic glutamate receptor 2 positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
LY2969822CHEMBL3545270Metabotropic glutamate receptor 2 agonistAGONISTChEMBL
LY2979165CHEMBL4303379Metabotropic glutamate receptor 2 agonistAGONISTChEMBL
LY404039CHEMBL375611Metabotropic glutamate receptor 2 agonistAGONISTChEMBL
POMAGLUMETAD METHIONIL ANHYDROUSCHEMBL2110730Metabotropic glutamate receptor 2 agonistAGONISTChEMBL

Trials16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04836559JNJ-40411813PHASE22025-07-03ClinicalTrials.gov
NCT03321617POMAGLUMETAD METHIONIL ANHYDROUSPHASE12021-12-01ClinicalTrials.gov
NCT01733654DECOGLURANTPHASE2ClinicalTrials.gov
NCT01582815JNJ-40411813PHASE2ClinicalTrials.gov
NCT01487083POMAGLUMETAD METHIONIL ANHYDROUSPHASE3ClinicalTrials.gov
NCT01457677DECOGLURANTPHASE2ClinicalTrials.gov
NCT01354353POMAGLUMETAD METHIONIL ANHYDROUSPHASE12021-09-14ClinicalTrials.gov
NCT01328093POMAGLUMETAD METHIONIL ANHYDROUSPHASE32022-09-07ClinicalTrials.gov
NCT01323205JNJ-40411813PHASE2ClinicalTrials.gov
NCT01307800POMAGLUMETAD METHIONIL ANHYDROUSPHASE32022-10-18ClinicalTrials.gov

1 to 10 of 16

See all 16 trials

NIH grants1,493

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRM2 papersNewest fiscal year
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes442025
R01MH062646Regulation of Signaling by mGluR5392025
R01MH084894Function of GPCR heteromeric complexes in brain332025
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect152025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders112025
P50AA012870Center for the Translational Neuroscience of Alcoholism72025
R01MH107615Therapeutic Efficacy of Ketamine Metabolites for Depression Treatment72025
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol62025
R01HL059949Structural Determinants of PIP2 Regulation62025
R01MH054137Structure and Function of Dopamine Receptors62025

1 to 10 of 1,493Source NIH's project files

See all 1,493 nih grants

Papers2,352

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Paraneoplastic neurological syndromes: an update on incidence, antibody discovery, and testing.Curr Opin Oncol202642710022PubTator, text miningPubMed
The Randomization Effect in a Double-Blind Placebo-Controlled Depression Study.J Clin Psychopharmacol202642684061PubTator, text miningPubMed
Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis.Schizophr Res202642364358PubTator, text miningPubMed
GPCR crosstalk beyond obligate dimerisation: Effector coincidence detection, compartmentation, and pharmacological implications.Pharmacol Ther202642263870PubTator, text miningPubMed
Investigating metabotropic glutamate receptors as molecular targets for next-generation pharmacotherapies for alcohol use disorder.Expert Opin Ther Targets202642132824PubTator, text miningPubMed
Suppression of neuropathic pain hypersensitivity by TRPM8 is mediated by mGluR group II and III receptors acting differentially on distinct nociceptor inputs to spinal cord.Front Pharmacol202642057849PubTator, text miningPubMed
Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord.bioRxiv202642039515PubTator, text miningPubMed
Molecular dissection of protein complexes isolated from sections of human brain.bioRxiv202641993362PubTator, text miningPubMed
GRP78 promotes rabies virus entry through interacting with viral receptors.J Virol202641979904PubTator, text miningPubMed
Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue.bioRxiv202641959310PubTator, text miningPubMed

1 to 10 of 2,352

See all 2,352 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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