Gene · 2912
GRM2: glutamate metabotropic receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GRM2: glutamate metabotropic receptor 2. Genes, record 2912. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2912
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14416 | Metabotropic glutamate receptor 2 | 872 | 31 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12545895 B2 | 2026-02-10 | 10 | Q14416 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47792 | Q14416 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11221 | Q14416 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6238 | Q14416 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1883 | Q14416 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6548 | Q14416 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1883 | Q14416 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6548 | Q14416 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11221 | Q14416 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 6238 | Q14416 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs6
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DECOGLURANT | CHEMBL3301593 | Metabotropic glutamate receptor 2 modulator | MODULATOR | ChEMBL |
| JNJ-40411813 | CHEMBL3337527 | Metabotropic glutamate receptor 2 positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| LY2969822 | CHEMBL3545270 | Metabotropic glutamate receptor 2 agonist | AGONIST | ChEMBL |
| LY2979165 | CHEMBL4303379 | Metabotropic glutamate receptor 2 agonist | AGONIST | ChEMBL |
| LY404039 | CHEMBL375611 | Metabotropic glutamate receptor 2 agonist | AGONIST | ChEMBL |
| POMAGLUMETAD METHIONIL ANHYDROUS | CHEMBL2110730 | Metabotropic glutamate receptor 2 agonist | AGONIST | ChEMBL |
Trials16
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04836559 | JNJ-40411813 | PHASE2 | 2025-07-03 | ClinicalTrials.gov |
| NCT03321617 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE1 | 2021-12-01 | ClinicalTrials.gov |
| NCT01733654 | DECOGLURANT | PHASE2 | ClinicalTrials.gov | |
| NCT01582815 | JNJ-40411813 | PHASE2 | ClinicalTrials.gov | |
| NCT01487083 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE3 | ClinicalTrials.gov | |
| NCT01457677 | DECOGLURANT | PHASE2 | ClinicalTrials.gov | |
| NCT01354353 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE1 | 2021-09-14 | ClinicalTrials.gov |
| NCT01328093 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE3 | 2022-09-07 | ClinicalTrials.gov |
| NCT01323205 | JNJ-40411813 | PHASE2 | ClinicalTrials.gov | |
| NCT01307800 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE3 | 2022-10-18 | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsNIH grants1,493
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GRM2 papers | Newest fiscal year |
|---|---|---|---|
| R01NS031373 | Functions of Metabotropic Glutamate Receptor Subtypes | 44 | 2025 |
| R01MH062646 | Regulation of Signaling by mGluR5 | 39 | 2025 |
| R01MH084894 | Function of GPCR heteromeric complexes in brain | 33 | 2025 |
| ZIAMH002857 | Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect | 15 | 2025 |
| ZIAMH002927 | Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders | 11 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 7 | 2025 |
| R01MH107615 | Therapeutic Efficacy of Ketamine Metabolites for Depression Treatment | 7 | 2025 |
| P60AA007611 | Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol | 6 | 2025 |
| R01HL059949 | Structural Determinants of PIP2 Regulation | 6 | 2025 |
| R01MH054137 | Structure and Function of Dopamine Receptors | 6 | 2025 |
1 to 10 of 1,493Source NIH's project files
See all 1,493 nih grantsPapers2,352
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Paraneoplastic neurological syndromes: an update on incidence, antibody discovery, and testing. | Curr Opin Oncol | 2026 | 42710022 | PubTator, text mining | PubMed |
| The Randomization Effect in a Double-Blind Placebo-Controlled Depression Study. | J Clin Psychopharmacol | 2026 | 42684061 | PubTator, text mining | PubMed |
| Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis. | Schizophr Res | 2026 | 42364358 | PubTator, text mining | PubMed |
| GPCR crosstalk beyond obligate dimerisation: Effector coincidence detection, compartmentation, and pharmacological implications. | Pharmacol Ther | 2026 | 42263870 | PubTator, text mining | PubMed |
| Investigating metabotropic glutamate receptors as molecular targets for next-generation pharmacotherapies for alcohol use disorder. | Expert Opin Ther Targets | 2026 | 42132824 | PubTator, text mining | PubMed |
| Suppression of neuropathic pain hypersensitivity by TRPM8 is mediated by mGluR group II and III receptors acting differentially on distinct nociceptor inputs to spinal cord. | Front Pharmacol | 2026 | 42057849 | PubTator, text mining | PubMed |
| Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord. | bioRxiv | 2026 | 42039515 | PubTator, text mining | PubMed |
| Molecular dissection of protein complexes isolated from sections of human brain. | bioRxiv | 2026 | 41993362 | PubTator, text mining | PubMed |
| GRP78 promotes rabies virus entry through interacting with viral receptors. | J Virol | 2026 | 41979904 | PubTator, text mining | PubMed |
| Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue. | bioRxiv | 2026 | 41959310 | PubTator, text mining | PubMed |
1 to 10 of 2,352
See all 2,352 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2912
GET https://conductscience.org/api/genes/v1/2912/patents?page=2