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Gene · 2913

GRM3: glutamate metabotropic receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRM3: glutamate metabotropic receptor 3. Genes, record 2913. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2913

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Gene

Symbol
GRM3
HGNC
Name
glutamate metabotropic receptor 3
HGNC
NCBI Gene ID
2913
NCBI Gene
HGNC ID
HGNC:4595
HGNC
Ensembl
ENSG00000198822
NCBI Gene
Aliases
GLUR3, GPRC1C, MGLUR3, mGlu3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14832Metabotropic glutamate receptor 387920Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12636345 B22026-05-2639Q14832Espacenet
US 12560619 B22026-02-2436Q14832Espacenet
JP 2026004568 A2026-01-1447794Q14832Espacenet
EP 4650780 A22025-11-198044Q14832Espacenet
EP 4641201 A22025-10-298156Q14832Espacenet
JP 2025147176 A2025-10-066242Q14832Espacenet
JP 2025529142 A2025-09-041884Q14832Espacenet
JP 2025529142 A2025-09-046549Q14832Espacenet
US 12371689 B22025-07-291884Q14832Espacenet
US 12371689 B22025-07-296549Q14832Espacenet

1 to 10 of 67

See all 67 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DECOGLURANTCHEMBL3301593Metabotropic glutamate receptor 3 modulatorMODULATORChEMBL
LY2969822CHEMBL3545270Metabotropic glutamate receptor 3 agonistAGONISTChEMBL
LY404039CHEMBL375611Metabotropic glutamate receptor 3 agonistAGONISTChEMBL
POMAGLUMETAD METHIONIL ANHYDROUSCHEMBL2110730Metabotropic glutamate receptor 3 agonistAGONISTChEMBL

Trials12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03321617POMAGLUMETAD METHIONIL ANHYDROUSPHASE12021-12-01ClinicalTrials.gov
NCT01733654DECOGLURANTPHASE2ClinicalTrials.gov
NCT01487083POMAGLUMETAD METHIONIL ANHYDROUSPHASE3ClinicalTrials.gov
NCT01457677DECOGLURANTPHASE2ClinicalTrials.gov
NCT01354353POMAGLUMETAD METHIONIL ANHYDROUSPHASE12021-09-14ClinicalTrials.gov
NCT01328093POMAGLUMETAD METHIONIL ANHYDROUSPHASE32022-09-07ClinicalTrials.gov
NCT01307800POMAGLUMETAD METHIONIL ANHYDROUSPHASE32022-10-18ClinicalTrials.gov
NCT01129674POMAGLUMETAD METHIONIL ANHYDROUSPHASE2/PHASE3ClinicalTrials.gov
NCT01052103POMAGLUMETAD METHIONIL ANHYDROUSPHASE22021-09-22ClinicalTrials.gov
NCT00845026POMAGLUMETAD METHIONIL ANHYDROUSPHASE22022-09-01ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

NIH grants1,644

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRM3 papersNewest fiscal year
R01MH062646Regulation of Signaling by mGluR5442025
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes412025
R01MH084894Function of GPCR heteromeric complexes in brain162025
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect132025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders112025
P30CA016672Cancer Center Support Grant62025
ZIADA000434Neurobiology Of Relapse To Opiate and Psychostimulant Drugs62025
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt52025
R01HL059949Structural Determinants of PIP2 Regulation52025
R01MH107615Therapeutic Efficacy of Ketamine Metabolites for Depression Treatment52025

1 to 10 of 1,644Source NIH's project files

See all 1,644 nih grants

Papers2,242

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Whole-Exome and Whole-Genome Sequencing of Candidate Pharmacogenomic and Schizophrenia-Related Genes in Sudanese Families with Schizophrenia.Pharmgenomics Pers Med202642703538PubTator, text miningPubMed
Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis.Schizophr Res202642364358PubTator, text miningPubMed
Distinctive Molecular Mechanisms in Higher Cortical Circuits Confer Vulnerability to Mental Disorders.Biol Psychiatry202642320779PubTator, text miningPubMed
Metabotropic Glutamate Receptor 3 Expression During Liver Disease Progression: Association with Inflammation and Cell Viability in Hepatocellular Carcinoma.Int J Mol Sci202642123462PubTator, text miningPubMed
Evaluation of triphenyl phosphate's pathogenic potential and molecular mechanisms in glioblastoma: an integrated network toxicology investigation employing multiple machine learning approaches.Transl Cancer Res202641969433PubTator, text miningPubMed
Longitudinal extensive anti-AMPA-GluR3-related transverse myelitis and favorable therapeutic response: A case report and review of literature.World J Clin Pediatr202641884049PubTator, text miningPubMed
Oncogenic GPR161 Drives Melanoma Proliferation and Metabolic Activity through TXNIP Inhibition.J Microbiol Biotechnol202641834581PubTator, text miningPubMed
Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis.Sci Rep202641813767PubTator, text miningPubMed
Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications.Neurooncol Adv202641768124PubTator, text miningPubMed
Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain.Front Cell Neurosci202641767744PubTator, text miningPubMed

1 to 10 of 2,242

See all 2,242 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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