Gene · 2913
GRM3: glutamate metabotropic receptor 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GRM3: glutamate metabotropic receptor 3. Genes, record 2913. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2913
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14832 | Metabotropic glutamate receptor 3 | 879 | 20 | Ensembl, GeneID, HGNC |
Source UniProt
Patents67
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12636345 B2 | 2026-05-26 | 39 | Q14832 | Espacenet |
| US 12560619 B2 | 2026-02-24 | 36 | Q14832 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47794 | Q14832 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8044 | Q14832 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8156 | Q14832 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6242 | Q14832 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1884 | Q14832 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6549 | Q14832 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1884 | Q14832 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6549 | Q14832 | Espacenet |
1 to 10 of 67
See all 67 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DECOGLURANT | CHEMBL3301593 | Metabotropic glutamate receptor 3 modulator | MODULATOR | ChEMBL |
| LY2969822 | CHEMBL3545270 | Metabotropic glutamate receptor 3 agonist | AGONIST | ChEMBL |
| LY404039 | CHEMBL375611 | Metabotropic glutamate receptor 3 agonist | AGONIST | ChEMBL |
| POMAGLUMETAD METHIONIL ANHYDROUS | CHEMBL2110730 | Metabotropic glutamate receptor 3 agonist | AGONIST | ChEMBL |
Trials12
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03321617 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE1 | 2021-12-01 | ClinicalTrials.gov |
| NCT01733654 | DECOGLURANT | PHASE2 | ClinicalTrials.gov | |
| NCT01487083 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE3 | ClinicalTrials.gov | |
| NCT01457677 | DECOGLURANT | PHASE2 | ClinicalTrials.gov | |
| NCT01354353 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE1 | 2021-09-14 | ClinicalTrials.gov |
| NCT01328093 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE3 | 2022-09-07 | ClinicalTrials.gov |
| NCT01307800 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE3 | 2022-10-18 | ClinicalTrials.gov |
| NCT01129674 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT01052103 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE2 | 2021-09-22 | ClinicalTrials.gov |
| NCT00845026 | POMAGLUMETAD METHIONIL ANHYDROUS | PHASE2 | 2022-09-01 | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsNIH grants1,644
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GRM3 papers | Newest fiscal year |
|---|---|---|---|
| R01MH062646 | Regulation of Signaling by mGluR5 | 44 | 2025 |
| R01NS031373 | Functions of Metabotropic Glutamate Receptor Subtypes | 41 | 2025 |
| R01MH084894 | Function of GPCR heteromeric complexes in brain | 16 | 2025 |
| ZIAMH002857 | Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect | 13 | 2025 |
| ZIAMH002927 | Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| ZIADA000434 | Neurobiology Of Relapse To Opiate and Psychostimulant Drugs | 6 | 2025 |
| P50HD103537 | Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt | 5 | 2025 |
| R01HL059949 | Structural Determinants of PIP2 Regulation | 5 | 2025 |
| R01MH107615 | Therapeutic Efficacy of Ketamine Metabolites for Depression Treatment | 5 | 2025 |
1 to 10 of 1,644Source NIH's project files
See all 1,644 nih grantsPapers2,242
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Whole-Exome and Whole-Genome Sequencing of Candidate Pharmacogenomic and Schizophrenia-Related Genes in Sudanese Families with Schizophrenia. | Pharmgenomics Pers Med | 2026 | 42703538 | PubTator, text mining | PubMed |
| Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis. | Schizophr Res | 2026 | 42364358 | PubTator, text mining | PubMed |
| Distinctive Molecular Mechanisms in Higher Cortical Circuits Confer Vulnerability to Mental Disorders. | Biol Psychiatry | 2026 | 42320779 | PubTator, text mining | PubMed |
| Metabotropic Glutamate Receptor 3 Expression During Liver Disease Progression: Association with Inflammation and Cell Viability in Hepatocellular Carcinoma. | Int J Mol Sci | 2026 | 42123462 | PubTator, text mining | PubMed |
| Evaluation of triphenyl phosphate's pathogenic potential and molecular mechanisms in glioblastoma: an integrated network toxicology investigation employing multiple machine learning approaches. | Transl Cancer Res | 2026 | 41969433 | PubTator, text mining | PubMed |
| Longitudinal extensive anti-AMPA-GluR3-related transverse myelitis and favorable therapeutic response: A case report and review of literature. | World J Clin Pediatr | 2026 | 41884049 | PubTator, text mining | PubMed |
| Oncogenic GPR161 Drives Melanoma Proliferation and Metabolic Activity through TXNIP Inhibition. | J Microbiol Biotechnol | 2026 | 41834581 | PubTator, text mining | PubMed |
| Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis. | Sci Rep | 2026 | 41813767 | PubTator, text mining | PubMed |
| Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications. | Neurooncol Adv | 2026 | 41768124 | PubTator, text mining | PubMed |
| Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain. | Front Cell Neurosci | 2026 | 41767744 | PubTator, text mining | PubMed |
1 to 10 of 2,242
See all 2,242 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2913
GET https://conductscience.org/api/genes/v1/2913/patents?page=2