Gene · 4881
NPR1: natriuretic peptide receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NPR1: natriuretic peptide receptor 1. Genes, record 4881. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4881
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16066 | Atrial natriuretic peptide receptor 1 | 1,061 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents71
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4725963 A1 | 2026-04-15 | 4 | P16066 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55057 | P16066 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8494 | P16066 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1279 | P16066 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8664 | P16066 | Espacenet |
| US 12410255 B2 | 2025-09-09 | 1 | P16066 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2889 | P16066 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2889 | P16066 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1279 | P16066 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8664 | P16066 | Espacenet |
1 to 10 of 71
See all 71 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials50
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04455477 | NESIRITIDE | ClinicalTrials.gov | ||
| NCT04318145 | PL-3994 | PHASE2 | ClinicalTrials.gov | |
| NCT03234751 | NESIRITIDE | PHASE1 | ClinicalTrials.gov | |
| NCT02608996 | NESIRITIDE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT01977859 | NESIRITIDE | PHASE1 | ClinicalTrials.gov | |
| NCT01941576 | NESIRITIDE | ClinicalTrials.gov | ||
| NCT01514357 | NESIRITIDE | PHASE1/PHASE2 | 2017-10-20 | ClinicalTrials.gov |
| NCT01440881 | NESIRITIDE | PHASE2 | 2014-03-06 | ClinicalTrials.gov |
| NCT01324739 | NESIRITIDE | ClinicalTrials.gov | ||
| NCT01304628 | PL-3994 | PHASE2 | ClinicalTrials.gov |
1 to 10 of 50
See all 50 trialsNIH grants898
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NPR1 papers | Newest fiscal year |
|---|---|---|---|
| P40OD010440 | Caenorhabditis Genetics Center | 16 | 2025 |
| R01HL084155 | Human Cardiorenal Syndrome | 6 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| R01DK133833 | ANP Receptor: Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Injury and Dysfunction | 5 | 2025 |
| R01HL049277 | Animal Models for Studying the Genetics of Complex Diseases | 5 | 2025 |
| R35GM118036 | Salicylic Acid in Immunity and Health: A Small Phytohormone with Big Physiological Impacts | 5 | 2025 |
| T32HL007111 | Cardiovasology | 5 | 2025 |
| R37GM070977 | Genetic analysis of innate immunity using C. elegans | 4 | 2025 |
| ZIADE000721 | Molecular Genetic Studies of Somatosensation | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 898Source NIH's project files
See all 898 nih grantsPapers1,742
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatiotemporal Dissection of the Infection Response to Bacterial Soft Rot in Non-heading Chinese cabbage. | Plant Dis | 2026 | 42754990 | PubTator, text mining | PubMed |
| Nano-enabled natriuretic peptide therapy in post-myocardial infarction heart failure: from functional NP deficiency to dual-axis (cGMP-dependent and -independent) cardioprotection. | Intern Emerg Med | 2026 | 42665772 | PubTator, text mining | PubMed |
| miRNA-mediated metabolic reprogramming is associated with recurrence in ovarian cancer. | Epigenomics | 2026 | 42629352 | PubTator, text mining | PubMed |
| Generation of ANP- and BNP-deficient human iPSC-derived cardiomyocytes reveals natriuretic peptide-dependent angiogenic paracrine effects. | J Cardiol | 2026 | 42537982 | PubTator, text mining | PubMed |
| Inhibitory mechanism of ANP on aldosterone production in human adrenocortical cells. | Endocr Connect | 2026 | 42535457 | PubTator, text mining | PubMed |
| Differential Susceptibility to OsHV-1 in Two Geographic Populations of Ark Clam (Scapharca broughtonii) Based on Transcriptomic and Proteomic Analysis. | Microorganisms | 2026 | 42513939 | PubTator, text mining | PubMed |
| Misregulation of T-box transcription factors drives BNP-NPR1 signalling underlying chronic itch. | Nat Commun | 2026 | 42469239 | PubTator, text mining | PubMed |
| Methyl Benzoate Acts as a Dusk-Associated Airborne Cue Activating NPR1-Dependent Defence Signalling. | Plant Cell Environ | 2026 | 42452802 | PubTator, text mining | PubMed |
| Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress. | Curr Biol | 2026 | 42409014 | PubTator, text mining | PubMed |
| Biologics for cardiovascular diseases: from bench to bedside. | Signal Transduct Target Ther | 2026 | 42366210 | PubTator, text mining | PubMed |
1 to 10 of 1,742
See all 1,742 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4881
GET https://conductscience.org/api/genes/v1/4881/patents?page=2