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Gene · 4881

NPR1: natriuretic peptide receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NPR1: natriuretic peptide receptor 1. Genes, record 4881. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4881

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Gene

Symbol
NPR1
HGNC
Name
natriuretic peptide receptor 1
HGNC
NCBI Gene ID
4881
NCBI Gene
HGNC ID
HGNC:7943
HGNC
Ensembl
ENSG00000169418
NCBI Gene
Aliases
ANP-A, ANPRA, ANPa, GC-A, GUC2A, GUCY2A, NPRA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16066Atrial natriuretic peptide receptor 11,06114Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4725963 A12026-04-154P16066Espacenet
JP 2026004568 A2026-01-1455057P16066Espacenet
EP 4650780 A22025-11-198494P16066Espacenet
EP 4640849 A22025-10-291279P16066Espacenet
EP 4641201 A22025-10-298664P16066Espacenet
US 12410255 B22025-09-091P16066Espacenet
JP 2025529142 A2025-09-042889P16066Espacenet
US 12371689 B22025-07-292889P16066Espacenet
JP 2025519096 A2025-06-241279P16066Espacenet
JP 2025517969 A2025-06-128664P16066Espacenet

1 to 10 of 71

See all 71 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CARPERITIDECHEMBL2104386Atrial natriuretic peptide receptor agonistAGONISTChEMBL
NESIRITIDECHEMBL1201668Atrial natriuretic peptide receptor A agonistAGONISTChEMBL
PL-3994CHEMBL4297320Atrial natriuretic peptide receptor A agonistAGONISTChEMBL

Trials50

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04455477NESIRITIDEClinicalTrials.gov
NCT04318145PL-3994PHASE2ClinicalTrials.gov
NCT03234751NESIRITIDEPHASE1ClinicalTrials.gov
NCT02608996NESIRITIDEPHASE1/PHASE2ClinicalTrials.gov
NCT01977859NESIRITIDEPHASE1ClinicalTrials.gov
NCT01941576NESIRITIDEClinicalTrials.gov
NCT01514357NESIRITIDEPHASE1/PHASE22017-10-20ClinicalTrials.gov
NCT01440881NESIRITIDEPHASE22014-03-06ClinicalTrials.gov
NCT01324739NESIRITIDEClinicalTrials.gov
NCT01304628PL-3994PHASE2ClinicalTrials.gov

1 to 10 of 50

See all 50 trials

NIH grants898

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNPR1 papersNewest fiscal year
P40OD010440Caenorhabditis Genetics Center162025
R01HL084155Human Cardiorenal Syndrome62025
P30CA014195Cancer Center Support Grant (CCSG)52025
R01DK133833ANP Receptor: Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Injury and Dysfunction52025
R01HL049277Animal Models for Studying the Genetics of Complex Diseases52025
R35GM118036Salicylic Acid in Immunity and Health: A Small Phytohormone with Big Physiological Impacts52025
T32HL007111Cardiovasology52025
R37GM070977Genetic analysis of innate immunity using C. elegans42025
ZIADE000721Molecular Genetic Studies of Somatosensation42025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 898Source NIH's project files

See all 898 nih grants

Papers1,742

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatiotemporal Dissection of the Infection Response to Bacterial Soft Rot in Non-heading Chinese cabbage.Plant Dis202642754990PubTator, text miningPubMed
Nano-enabled natriuretic peptide therapy in post-myocardial infarction heart failure: from functional NP deficiency to dual-axis (cGMP-dependent and -independent) cardioprotection.Intern Emerg Med202642665772PubTator, text miningPubMed
miRNA-mediated metabolic reprogramming is associated with recurrence in ovarian cancer.Epigenomics202642629352PubTator, text miningPubMed
Generation of ANP- and BNP-deficient human iPSC-derived cardiomyocytes reveals natriuretic peptide-dependent angiogenic paracrine effects.J Cardiol202642537982PubTator, text miningPubMed
Inhibitory mechanism of ANP on aldosterone production in human adrenocortical cells.Endocr Connect202642535457PubTator, text miningPubMed
Differential Susceptibility to OsHV-1 in Two Geographic Populations of Ark Clam (Scapharca broughtonii) Based on Transcriptomic and Proteomic Analysis.Microorganisms202642513939PubTator, text miningPubMed
Misregulation of T-box transcription factors drives BNP-NPR1 signalling underlying chronic itch.Nat Commun202642469239PubTator, text miningPubMed
Methyl Benzoate Acts as a Dusk-Associated Airborne Cue Activating NPR1-Dependent Defence Signalling.Plant Cell Environ202642452802PubTator, text miningPubMed
Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.Curr Biol202642409014PubTator, text miningPubMed
Biologics for cardiovascular diseases: from bench to bedside.Signal Transduct Target Ther202642366210PubTator, text miningPubMed

1 to 10 of 1,742

See all 1,742 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4881

GET https://conductscience.org/api/genes/v1/4881/patents?page=2