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Gene · 4921

DDR2: discoidin domain receptor tyrosine kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDR2: discoidin domain receptor tyrosine kinase 2. Genes, record 4921. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4921

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Gene

Symbol
DDR2
HGNC
Name
discoidin domain receptor tyrosine kinase 2
HGNC
NCBI Gene ID
4921
NCBI Gene
HGNC ID
HGNC:2731
HGNC
Ensembl
ENSG00000162733
NCBI Gene
Aliases
DDR2-N, MIG20a, NTRKR3, TKT, TYRO10, WRCN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16832Discoidin domain-containing receptor 28555Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443945Q16832Espacenet
JP 2026004568 A2026-01-1443946Q16832Espacenet
EP 4650780 A22025-11-198319Q16832Espacenet
EP 4641201 A22025-10-298514Q16832Espacenet
JP 2025147176 A2025-10-064072Q16832Espacenet
JP 2025147176 A2025-10-064073Q16832Espacenet
JP 2025529142 A2025-09-041234Q16832Espacenet
JP 2025529142 A2025-09-046122Q16832Espacenet
US 12371689 B22025-07-291234Q16832Espacenet
US 12371689 B22025-07-296122Q16832Espacenet

1 to 10 of 74

See all 74 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
REGORAFENIBCHEMBL1946170Discoidin domain-containing receptor 2 inhibitorINHIBITOR

Source ChEMBL

Trials249

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07463248REGORAFENIBPHASE2ClinicalTrials.gov
NCT07379047REGORAFENIBPHASE2/PHASE3ClinicalTrials.gov
NCT07343791REGORAFENIBEARLY_PHASE1ClinicalTrials.gov
NCT07328009REGORAFENIBPHASE2ClinicalTrials.gov

1 to 10 of 249

See all 249 trials

NIH grants1,545

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDR2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant342025
P30CA008748Cancer Center Support Grant192025
P30CA076292Moffitt Cancer Center Support Grant152025
P30AR069620Michigan Integrative Musculoskeletal Health Core Center (Overall Application)92025
P30CA022453CANCER CENTER SUPPORT GRANT82025
P30CA091842Cancer Center Support Grant82025
R01DE029465Discoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone Formation82025
P30CA046934University of Colorado Cancer Center Support Grant72025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202862025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025

1 to 10 of 1,545Source NIH's project files

See all 1,545 nih grants

Papers2,653

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Donor-dependent heterogeneity and matrix-remodeling transcriptional programs in COL2A1-variant urine-derived cell cultures with IGF1-associated cell-state shifts.Front Cell Dev Biol202642745831PubTator, text miningPubMed
Quantitative structural alterations of collagen dictate discoidin domain receptor 2 binding efficacy and CAL-27 cell adhesion behaviors.Int J Biol Macromol202642722254PubTator, text miningPubMed
Vascular adventitial cells and vascular remodeling: when a harp of thousand strings does not keep in tune so long.Front Physiol202642707986PubTator, text miningPubMed
Prominent Myxoid and Collagenous Stromal Patterns in Dedifferentiated Liposarcoma: A Comparative Analysis of Immunophenotypic and Genomic Profiles.Anticancer Res202642674680PubTator, text miningPubMed
Type I collagen matrix signaling in cancer: receptor sensing and mechanotransduction.Cell Signal202642660397PubTator, text miningPubMed
Long Non-Coding RNAs and Circular RNAs in the Pathobiology of T-Cell Lymphoma.Cancers (Basel)202642649850PubTator, text miningPubMed
Roles of integrin β1 and discoidin domain receptor 2 in cranial regeneration and skeletal progenitor cell function.Int J Oral Sci202642613320PubTator, text miningPubMed
Subcellular proteomic analysis of the DDR2 interactome in a neuronal cell model exposed to Aβ42.Biochim Biophys Acta Proteins Proteom202642612957PubTator, text miningPubMed
SERPINH1 expression represents a reliable biomarker of human breast cancer aggressiveness.Biol Direct202642464413PubTator, text miningPubMed
Characterization of white adipocyte heterogeneity using data-driven microscopy.Int J Obes (Lond)202642420601PubTator, text miningPubMed

1 to 10 of 2,653

See all 2,653 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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