Gene · 6337
SCNN1A: sodium channel epithelial 1 subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SCNN1A: sodium channel epithelial 1 subunit alpha. Genes, record 6337. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6337
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P37088 | Epithelial sodium channel subunit alpha | 669 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63867 | P37088 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 86 | P37088 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 505 | P37088 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3852 | P37088 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3852 | P37088 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 86 | P37088 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 505 | P37088 | Espacenet |
| US 11761043 B2 | 2023-09-19 | 25 | P37088 | Espacenet |
| US 11674179 B2 | 2023-06-13 | 25 | P37088 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80184 | P37088 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMILORIDE | CHEMBL945 | Amiloride-sensitive sodium channel, ENaC blocker | BLOCKER | ChEMBL |
| AMILORIDE HYDROCHLORIDE | CHEMBL1398126 | Amiloride-sensitive sodium channel, ENaC blocker | BLOCKER | ChEMBL |
| COFIRASERSEN | CHEMBL4650476 | Amiloride-sensitive sodium channel, ENaC mRNA antisense inhibitor | ANTISENSE INHIBITOR | ChEMBL |
| IDREVLORIDE | CHEMBL5095031 | Amiloride-sensitive sodium channel, ENaC blocker | BLOCKER | ChEMBL |
| TRIAMTERENE | CHEMBL585 | Amiloride-sensitive sodium channel, ENaC blocker | BLOCKER | ChEMBL |
Trials42
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06923709 | AMILORIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06416735 | AMILORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06224673 | AMILORIDE | PHASE2 | ClinicalTrials.gov | |
| NCT05753059 | AMILORIDE | PHASE1 | ClinicalTrials.gov | |
| NCT05079789 | AMILORIDE | PHASE3 | 2025-01-14 | ClinicalTrials.gov |
| NCT04441788 | COFIRASERSEN | PHASE2 | 2022-12-20 | ClinicalTrials.gov |
| NCT03928145 | AMILORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT03837626 | AMILORIDE | PHASE2/PHASE3 | 2025-12-30 | ClinicalTrials.gov |
| NCT03647228 | COFIRASERSEN | PHASE1 | ClinicalTrials.gov | |
| NCT03036748 | AMILORIDE | ClinicalTrials.gov |
1 to 10 of 42
See all 42 trialsNIH grants1,064
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SCNN1A papers | Newest fiscal year |
|---|---|---|---|
| P30DK065988 | UNC Cystic Fibrosis Research and Translation Core Center | 8 | 2025 |
| R01HL134828 | Novel exosomal niches for alveolar stem cell-bassed repair of ARDS | 5 | 2025 |
| R01HL147818 | ENaC regulation and its role in blood pressure homeostasis | 5 | 2025 |
| P30DK072482 | UAB CF Research and Translation Core Center | 4 | 2025 |
| R01HL144941 | Immune Mechanisms of Salt-Sensitive hypertension | 4 | 2025 |
| I01BX004871 | The function and regulation of intrarenal aldosterone synthase in ischemia-induced hypertension and renal injury | 3 | 2025 |
| IK6BX005223 | BLR&D Research Career Scientist Award Application | 3 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 3 | 2025 |
| P30DK054759 | Precision Medicine Center for Cystic Fibrosis | 3 | 2025 |
| R01DK056695 | SGK Regulation of Epithelial Sodium Transport | 3 | 2025 |
1 to 10 of 1,064Source NIH's project files
See all 1,064 nih grantsPapers1,482
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cough hypersensitivity risk increases during heatwaves and can be reduced by inhalation of alkaline aerosols of endogenous ions. | Sci Rep | 2026 | 42744885 | PubTator, text mining | PubMed |
| Clinical, Biochemical, and Molecular Spectrum of Pseudohypoaldosteronism Type 1B in Indian Children: A Multicentric Case Series. | Clin Endocrinol (Oxf) | 2026 | 42549990 | PubTator, text mining | PubMed |
| HECW2 suppresses non-small cell lung cancer progression by destabilizing SCNN1A and inactivating AKT/mTOR pathway. | Biochem Pharmacol | 2026 | 42537707 | PubTator, text mining | PubMed |
| Distinct functional roles of the GRIP domains in α-, β-, γ-, and δ-ENaC. | J Biol Chem | 2026 | 42463047 | PubTator, text mining | PubMed |
| From idiopathic pulmonary hemosiderosis to ENaC channelopathy: a novel SCNN1G mutation. | Am J Respir Crit Care Med | 2026 | 42412512 | PubTator, text mining | PubMed |
| Liddle Syndrome Presenting as Hypertensive Crisis and Myocardial Injury in a Young Male: A Case Report. | Case Rep Nephrol | 2026 | 42371545 | PubTator, text mining | PubMed |
| Differential Host Gene Expression Associated with Non-Lactobacillus-dominant Vaginal Microbiomes During Pregnancy. | Res Sq | 2026 | 42245806 | PubTator, text mining | PubMed |
| Maternal high-fat high-energy diet impairs surfactant maturation in the non-human primate fetal lung. | Int J Obes (Lond) | 2026 | 42045659 | PubTator, text mining | PubMed |
| Congenital aldosterone deficiency and its resistance. | Endocr J | 2026 | 41905953 | PubTator, text mining | PubMed |
| Circadian reprogramming by timed sodium intake reveals transcriptional pathways of daily salt handling in the colon. | Sci Adv | 2026 | 41824567 | PubTator, text mining | PubMed |
1 to 10 of 1,482
See all 1,482 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6337
GET https://conductscience.org/api/genes/v1/6337/patents?page=2