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Gene · 6337

SCNN1A: sodium channel epithelial 1 subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCNN1A: sodium channel epithelial 1 subunit alpha. Genes, record 6337. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6337

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Gene

Symbol
SCNN1A
HGNC
Name
sodium channel epithelial 1 subunit alpha
HGNC
NCBI Gene ID
6337
NCBI Gene
HGNC ID
HGNC:10599
HGNC
Ensembl
ENSG00000111319
NCBI Gene
Aliases
BESC2, ENaCa, ENaCalpha, LIDLS3, PHA1B1, SCNEA, SCNN1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P37088Epithelial sodium channel subunit alpha6693Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463867P37088Espacenet
EP 4640849 A22025-10-2986P37088Espacenet
EP 4641201 A22025-10-29505P37088Espacenet
JP 2025529142 A2025-09-043852P37088Espacenet
US 12371689 B22025-07-293852P37088Espacenet
JP 2025519096 A2025-06-2486P37088Espacenet
JP 2025517969 A2025-06-12505P37088Espacenet
US 11761043 B22023-09-1925P37088Espacenet
US 11674179 B22023-06-1325P37088Espacenet
US 11446398 B22022-09-2080184P37088Espacenet

1 to 10 of 56

See all 56 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMILORIDECHEMBL945Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
AMILORIDE HYDROCHLORIDECHEMBL1398126Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
COFIRASERSENCHEMBL4650476Amiloride-sensitive sodium channel, ENaC mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
IDREVLORIDECHEMBL5095031Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
TRIAMTERENECHEMBL585Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL

Trials42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06923709AMILORIDEPHASE2ClinicalTrials.gov
NCT06416735AMILORIDEPHASE3ClinicalTrials.gov
NCT06224673AMILORIDEPHASE2ClinicalTrials.gov
NCT05753059AMILORIDEPHASE1ClinicalTrials.gov
NCT05079789AMILORIDEPHASE32025-01-14ClinicalTrials.gov
NCT04441788COFIRASERSENPHASE22022-12-20ClinicalTrials.gov
NCT03928145AMILORIDEPHASE3ClinicalTrials.gov
NCT03837626AMILORIDEPHASE2/PHASE32025-12-30ClinicalTrials.gov
NCT03647228COFIRASERSENPHASE1ClinicalTrials.gov
NCT03036748AMILORIDEClinicalTrials.gov

1 to 10 of 42

See all 42 trials

NIH grants1,064

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCNN1A papersNewest fiscal year
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center82025
R01HL134828Novel exosomal niches for alveolar stem cell-bassed repair of ARDS52025
R01HL147818ENaC regulation and its role in blood pressure homeostasis52025
P30DK072482UAB CF Research and Translation Core Center42025
R01HL144941Immune Mechanisms of Salt-Sensitive hypertension42025
I01BX004871The function and regulation of intrarenal aldosterone synthase in ischemia-induced hypertension and renal injury32025
IK6BX005223BLR&D Research Career Scientist Award Application32025
P30CA072720Cancer Center Support Grant32025
P30DK054759Precision Medicine Center for Cystic Fibrosis32025
R01DK056695SGK Regulation of Epithelial Sodium Transport32025

1 to 10 of 1,064Source NIH's project files

See all 1,064 nih grants

Papers1,482

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cough hypersensitivity risk increases during heatwaves and can be reduced by inhalation of alkaline aerosols of endogenous ions.Sci Rep202642744885PubTator, text miningPubMed
Clinical, Biochemical, and Molecular Spectrum of Pseudohypoaldosteronism Type 1B in Indian Children: A Multicentric Case Series.Clin Endocrinol (Oxf)202642549990PubTator, text miningPubMed
HECW2 suppresses non-small cell lung cancer progression by destabilizing SCNN1A and inactivating AKT/mTOR pathway.Biochem Pharmacol202642537707PubTator, text miningPubMed
Distinct functional roles of the GRIP domains in α-, β-, γ-, and δ-ENaC.J Biol Chem202642463047PubTator, text miningPubMed
From idiopathic pulmonary hemosiderosis to ENaC channelopathy: a novel SCNN1G mutation.Am J Respir Crit Care Med202642412512PubTator, text miningPubMed
Liddle Syndrome Presenting as Hypertensive Crisis and Myocardial Injury in a Young Male: A Case Report.Case Rep Nephrol202642371545PubTator, text miningPubMed
Differential Host Gene Expression Associated with Non-Lactobacillus-dominant Vaginal Microbiomes During Pregnancy.Res Sq202642245806PubTator, text miningPubMed
Maternal high-fat high-energy diet impairs surfactant maturation in the non-human primate fetal lung.Int J Obes (Lond)202642045659PubTator, text miningPubMed
Congenital aldosterone deficiency and its resistance.Endocr J202641905953PubTator, text miningPubMed
Circadian reprogramming by timed sodium intake reveals transcriptional pathways of daily salt handling in the colon.Sci Adv202641824567PubTator, text miningPubMed

1 to 10 of 1,482

See all 1,482 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6337

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