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Gene · 6338

SCNN1B: sodium channel epithelial 1 subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCNN1B: sodium channel epithelial 1 subunit beta. Genes, record 6338. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6338

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Gene

Symbol
SCNN1B
HGNC
Name
sodium channel epithelial 1 subunit beta
HGNC
NCBI Gene ID
6338
NCBI Gene
HGNC ID
HGNC:10600
HGNC
Ensembl
ENSG00000168447
NCBI Gene
Aliases
BESC1, ENaCb, ENaCbeta, LIDLS1, PHA1B2, SCNEB, beta-ENaC, beta-NaCH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51168Epithelial sodium channel subunit beta6405Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463870P51168Espacenet
EP 4641201 A22025-10-296881P51168Espacenet
JP 2025529142 A2025-09-043853P51168Espacenet
US 12371689 B22025-07-293853P51168Espacenet
JP 2025517969 A2025-06-126881P51168Espacenet
US 11446398 B22022-09-2080192P51168Espacenet
US 11400116 B22022-08-0296P51168Espacenet
JP 2022524081 A2022-04-27183163P51168Espacenet
JP 2022059100 A2022-04-136P51168Espacenet
US 11078247 B22021-08-0310009P51168Espacenet

1 to 10 of 34

See all 34 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMILORIDECHEMBL945Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
AMILORIDE HYDROCHLORIDECHEMBL1398126Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
COFIRASERSENCHEMBL4650476Amiloride-sensitive sodium channel, ENaC mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
IDREVLORIDECHEMBL5095031Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
TRIAMTERENECHEMBL585Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL

Trials42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06923709AMILORIDEPHASE2ClinicalTrials.gov
NCT06416735AMILORIDEPHASE3ClinicalTrials.gov
NCT06224673AMILORIDEPHASE2ClinicalTrials.gov
NCT05753059AMILORIDEPHASE1ClinicalTrials.gov
NCT05079789AMILORIDEPHASE32025-01-14ClinicalTrials.gov
NCT04441788COFIRASERSENPHASE22022-12-20ClinicalTrials.gov
NCT03928145AMILORIDEPHASE3ClinicalTrials.gov
NCT03837626AMILORIDEPHASE2/PHASE32025-12-30ClinicalTrials.gov
NCT03647228COFIRASERSENPHASE1ClinicalTrials.gov
NCT03036748AMILORIDEClinicalTrials.gov

1 to 10 of 42

See all 42 trials

NIH grants719

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCNN1B papersNewest fiscal year
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center122025
R01HL147818ENaC regulation and its role in blood pressure homeostasis62025
R01HL031197Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury52025
P30DK054759Precision Medicine Center for Cystic Fibrosis32025
P30DK072482UAB CF Research and Translation Core Center32025
R01DK056695SGK Regulation of Epithelial Sodium Transport32025
R01HL144941Immune Mechanisms of Salt-Sensitive hypertension32025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases22025
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 222025
P30ES005605Environmental Health Sciences Research Center22025

1 to 10 of 719Source NIH's project files

See all 719 nih grants

Papers971

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cough hypersensitivity risk increases during heatwaves and can be reduced by inhalation of alkaline aerosols of endogenous ions.Sci Rep202642744885PubTator, text miningPubMed
Carbocisteine Reduces Airway Mucus Obstruction and Alters Inflammatory Cell Populations in a Model of Muco-Obstructive Lung Disease.Immunol Cell Biol202642596503PubTator, text miningPubMed
ENaC phosphorylation facilitates ankyrin-3 interaction critical for renal sodium balance.PNAS Nexus202642568805PubTator, text miningPubMed
Clinical, Biochemical, and Molecular Spectrum of Pseudohypoaldosteronism Type 1B in Indian Children: A Multicentric Case Series.Clin Endocrinol (Oxf)202642549990PubTator, text miningPubMed
Liddle syndrome caused by SCNN1B mutation presenting with severe early-onset hypertension and hypokalemia in an adolescent: a case report.BMC Endocr Disord202642426704PubTator, text miningPubMed
Liddle Syndrome Presenting as Hypertensive Crisis and Myocardial Injury in a Young Male: A Case Report.Case Rep Nephrol202642371545PubTator, text miningPubMed
A positive feedback loop of HK3-mediated activation of NF-κB modulates glucose metabolism and promotes proliferation and metastasis in glioblastoma.Int J Biol Macromol202642217708PubTator, text miningPubMed
A Novel Homozygous SCNN1B Variant Causing Severe Systemic Pseudohypoaldosteronism Type 1B in a Saudi Infant: A Case Report.Cureus202642077744PubTator, text miningPubMed
Microarray Analysis of Human Abdominal Aortic Aneurysm With Emphasis on Cardiovascular Genes Revealed Differentially Expressed Genes.In Vivo202642049434PubTator, text miningPubMed
Maternal high-fat high-energy diet impairs surfactant maturation in the non-human primate fetal lung.Int J Obes (Lond)202642045659PubTator, text miningPubMed

1 to 10 of 971

See all 971 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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