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Gene · 6340

SCNN1G: sodium channel epithelial 1 subunit gamma

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCNN1G: sodium channel epithelial 1 subunit gamma. Genes, record 6340. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6340

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Gene

Symbol
SCNN1G
HGNC
Name
sodium channel epithelial 1 subunit gamma
HGNC
NCBI Gene ID
6340
NCBI Gene
HGNC ID
HGNC:10602
HGNC
Ensembl
ENSG00000166828
NCBI Gene
Aliases
BESC3, ENaCg, ENaCgamma, LDLS2, PHA1, PHA1B3, SCNEG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51170Epithelial sodium channel subunit gamma6495Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463877P51170Espacenet
EP 4641201 A22025-10-293559P51170Espacenet
JP 2025529142 A2025-09-043855P51170Espacenet
US 12371689 B22025-07-293855P51170Espacenet
JP 2025517969 A2025-06-123559P51170Espacenet
JP 2025032204 A2025-03-1135313P51170Espacenet
EP 4461818 A22024-11-1335313P51170Espacenet
JP 2023058610 A2023-04-2535313P51170Espacenet
US 11446398 B22022-09-2080205P51170Espacenet
US 11400116 B22022-08-02759P51170Espacenet

1 to 10 of 67

See all 67 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMILORIDECHEMBL945Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
AMILORIDE HYDROCHLORIDECHEMBL1398126Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
COFIRASERSENCHEMBL4650476Amiloride-sensitive sodium channel, ENaC mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
IDREVLORIDECHEMBL5095031Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL
TRIAMTERENECHEMBL585Amiloride-sensitive sodium channel, ENaC blockerBLOCKERChEMBL

Trials42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06923709AMILORIDEPHASE2ClinicalTrials.gov
NCT06416735AMILORIDEPHASE3ClinicalTrials.gov
NCT06224673AMILORIDEPHASE2ClinicalTrials.gov
NCT05753059AMILORIDEPHASE1ClinicalTrials.gov
NCT05079789AMILORIDEPHASE32025-01-14ClinicalTrials.gov
NCT04441788COFIRASERSENPHASE22022-12-20ClinicalTrials.gov
NCT03928145AMILORIDEPHASE3ClinicalTrials.gov
NCT03837626AMILORIDEPHASE2/PHASE32025-12-30ClinicalTrials.gov
NCT03647228COFIRASERSENPHASE1ClinicalTrials.gov
NCT03036748AMILORIDEClinicalTrials.gov

1 to 10 of 42

See all 42 trials

NIH grants675

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCNN1G papersNewest fiscal year
R01HL031197Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury72025
R01HL147818ENaC regulation and its role in blood pressure homeostasis72025
P30DK054759Precision Medicine Center for Cystic Fibrosis52025
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center42025
P40OD010440Caenorhabditis Genetics Center42025
P20GM103432Wyoming IDeA Networks for Biomedical Research Excellence Phase 432025
R01HL134828Novel exosomal niches for alveolar stem cell-bassed repair of ARDS32025
R01HL144941Immune Mechanisms of Salt-Sensitive hypertension32025
I01BX000893Role of M1 Cytokines in the Progression of Chronic Kidney Disease22025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases22025

1 to 10 of 675Source NIH's project files

See all 675 nih grants

Papers1,012

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proteinuria is associated with a high abundance of urine extracellular vesicles from collecting duct principal cells.Am J Physiol Renal Physiol202642629991PubTator, text miningPubMed
Clinical, Biochemical, and Molecular Spectrum of Pseudohypoaldosteronism Type 1B in Indian Children: A Multicentric Case Series.Clin Endocrinol (Oxf)202642549990PubTator, text miningPubMed
Integrative Multi-Transcriptomic Uncovers Actionable Signatures and Drug Repurposing Candidates for ccRCC-Hypertension Comorbidity.Cancers (Basel)202642512315PubTator, text miningPubMed
Distinct functional roles of the GRIP domains in α-, β-, γ-, and δ-ENaC.J Biol Chem202642463047PubTator, text miningPubMed
Liddle Syndrome Presenting as Hypertensive Crisis and Myocardial Injury in a Young Male: A Case Report.Case Rep Nephrol202642371545PubTator, text miningPubMed
Paracellular transport along the nephron in physiology and pathophysiology.Curr Opin Nephrol Hypertens202641934123PubTator, text miningPubMed
Congenital aldosterone deficiency and its resistance.Endocr J202641905953PubTator, text miningPubMed
Connectivity of the Superior Temporal Polysensory Area With the Presubiculum, Parasubiculum, Entorhinal Cortex, and Claustrum-Endopiriform Complex in the Common Marmoset (Callithrix jacchus).J Comp Neurol202641878825PubTator, text miningPubMed
Circadian reprogramming by timed sodium intake reveals transcriptional pathways of daily salt handling in the colon.Sci Adv202641824567PubTator, text miningPubMed
Visual Cortical Lateralization in Activations and Functional Connectivity to the Sight of Faces, Scenes, Body Parts, and Tools.Hum Brain Mapp202641804040PubTator, text miningPubMed

1 to 10 of 1,012

See all 1,012 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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