Gene · 6559
SLC12A3: solute carrier family 12 member 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC12A3: solute carrier family 12 member 3. Genes, record 6559. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6559
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P55017 | Solute carrier family 12 member 3 | 1,021 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents12
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63991 | P55017 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3990 | P55017 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3990 | P55017 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35721 | P55017 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35721 | P55017 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 35721 | P55017 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80397 | P55017 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183368 | P55017 | Espacenet |
| JP 2020508652 A | 2020-03-26 | 35721 | P55017 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 244426 | P55017 | Espacenet |
1 to 10 of 12
See all 12 patentsDrugs14
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BENDROFLUMETHIAZIDE | CHEMBL1684 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| BENZTHIAZIDE | CHEMBL1201039 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| CHLOROTHIAZIDE | CHEMBL842 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| CHLOROTHIAZIDE SODIUM | CHEMBL1200616 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| CHLORTHALIDONE | CHEMBL1055 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| CYCLOTHIAZIDE | CHEMBL61593 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| HYDROCHLOROTHIAZIDE | CHEMBL435 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| HYDROFLUMETHIAZIDE | CHEMBL1763 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| INDAPAMIDE | CHEMBL406 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
| METHYCLOTHIAZIDE | CHEMBL1577 | Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 14
See all 14 drugsTrials334
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07544888 | HYDROCHLOROTHIAZIDE | PHASE1 | ClinicalTrials.gov | |
| NCT07469722 | HYDROCHLOROTHIAZIDE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07458880 | HYDROCHLOROTHIAZIDE | ClinicalTrials.gov | ||
| NCT07372040 | METOLAZONE | PHASE2 | ClinicalTrials.gov | |
| NCT07271420 | CHLORTHALIDONE | PHASE4 | ClinicalTrials.gov | |
| NCT07271420 | HYDROCHLOROTHIAZIDE | PHASE4 | ClinicalTrials.gov | |
| NCT07259733 | INDAPAMIDE | ClinicalTrials.gov | ||
| NCT07116863 | CHLORTHALIDONE | PHASE3 | ClinicalTrials.gov | |
| NCT07064525 | INDAPAMIDE | PHASE2 | ClinicalTrials.gov | |
| NCT07020104 | HYDROCHLOROTHIAZIDE | ClinicalTrials.gov |
1 to 10 of 334
See all 334 trialsNIH grants1,333
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC12A3 papers | Newest fiscal year |
|---|---|---|---|
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 52 | 2025 |
| R01DK098141 | Regulation of renal ion transport by the CUL3-WNK-SPAK pathway | 14 | 2025 |
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 12 | 2025 |
| R01DK110358 | Regulation of WNK signaling by potassium and Mo25: structure, function and physiology | 9 | 2025 |
| R01DK110375 | Coordinated SLC12A3/SLC12A6/SL26A4 electroneutral transport pathways maintain K+ homeostasis and acid-base balance | 8 | 2025 |
| R01DK054231 | Molecular of ROMK Channel Function | 5 | 2025 |
| R01DK133220 | Role of Kir4.1 in regulating NCC and ROMK in DCT | 5 | 2025 |
| R01HL147818 | ENaC regulation and its role in blood pressure homeostasis | 5 | 2025 |
| ZIAHL001285 | Solute And Water Transport In Renal Epithelia | 5 | 2025 |
| I01BX000893 | Role of M1 Cytokines in the Progression of Chronic Kidney Disease | 4 | 2025 |
1 to 10 of 1,333Source NIH's project files
See all 1,333 nih grantsPapers2,457
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Long-Standing Hypokalemia and Hypomagnesemia in a 61 Year-Old Woman: A Delayed Diagnosis of Gitelman Syndrome. | Electrolyte Blood Press | 2026 | 42812717 | PubTator, text mining | PubMed |
| Monogenic Kidney Disorders as Hidden Drivers of Electrolyte Imbalance and Hypertension. | Electrolyte Blood Press | 2026 | 42812492 | PubTator, text mining | PubMed |
| Dapagliflozin Beyond Glucose Lowering: Mechanisms of Renal and Systemic Protection. | Pathophysiology | 2026 | 42784236 | PubTator, text mining | PubMed |
| Symptom Burden and Clinical Clues in Gitelman Syndrome and Pseudo-Gitelman Syndrome. | Kidney360 | 2026 | 42776593 | PubTator, text mining | PubMed |
| Symptomatic heterozygous Gitelman syndrome in a professional baseball player: a case report. | J Osteopath Med | 2026 | 42776028 | PubTator, text mining | PubMed |
| Temporal dynamics of urinary extracellular vesicle excretion and cargo in healthy subjects over 24 h. | Am J Physiol Renal Physiol | 2026 | 42775544 | PubTator, text mining | PubMed |
| Mitochondrial dysfunction drives metabolic reprogramming in Gitelman syndrome: insights from proteomics and isogenic modeling. | Hum Genet | 2026 | 42766034 | PubTator, text mining | PubMed |
| Dual-crosslinked calcium alginate/nanocrystalline cellulose bio-nanocomposite films with enhanced thermomechanical and rheological properties. | Int J Biol Macromol | 2026 | 42748999 | PubTator, text mining | PubMed |
| Late diagnosis of Gitelman syndrome in an elderly patient: identification of a novel SLC12A3 pathogenic variant. | J Bras Nefrol | 2026 | 42743372 | PubTator, text mining | PubMed |
| Perioperative management of a patient with retrosternal giant goiter and Gitelman syndrome: a case report. | Front Med (Lausanne) | 2026 | 42718562 | PubTator, text mining | PubMed |
1 to 10 of 2,457
See all 2,457 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6559
GET https://conductscience.org/api/genes/v1/6559/patents