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Gene · 6559

SLC12A3: solute carrier family 12 member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC12A3: solute carrier family 12 member 3. Genes, record 6559. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6559

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Gene

Symbol
SLC12A3
HGNC
Name
solute carrier family 12 member 3
HGNC
NCBI Gene ID
6559
NCBI Gene
HGNC ID
HGNC:10912
HGNC
Ensembl
ENSG00000070915
NCBI Gene
Aliases
NCC, NCCT, TSC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55017Solute carrier family 12 member 31,02112Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463991P55017Espacenet
JP 2025529142 A2025-09-043990P55017Espacenet
US 12371689 B22025-07-293990P55017Espacenet
JP 2025032204 A2025-03-1135721P55017Espacenet
EP 4461818 A22024-11-1335721P55017Espacenet
JP 2023058610 A2023-04-2535721P55017Espacenet
US 11446398 B22022-09-2080397P55017Espacenet
JP 2022524081 A2022-04-27183368P55017Espacenet
JP 2020508652 A2020-03-2635721P55017Espacenet
JP 2019054813 A2019-04-11244426P55017Espacenet

1 to 10 of 12

See all 12 patents

Drugs14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BENDROFLUMETHIAZIDECHEMBL1684Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
BENZTHIAZIDECHEMBL1201039Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
CHLOROTHIAZIDECHEMBL842Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
CHLOROTHIAZIDE SODIUMCHEMBL1200616Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
CHLORTHALIDONECHEMBL1055Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
CYCLOTHIAZIDECHEMBL61593Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
HYDROCHLOROTHIAZIDECHEMBL435Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
HYDROFLUMETHIAZIDECHEMBL1763Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
INDAPAMIDECHEMBL406Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL
METHYCLOTHIAZIDECHEMBL1577Thiazide-sensitive sodium-chloride cotransporter inhibitorINHIBITORChEMBL

1 to 10 of 14

See all 14 drugs

Trials334

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07544888HYDROCHLOROTHIAZIDEPHASE1ClinicalTrials.gov
NCT07469722HYDROCHLOROTHIAZIDEPHASE2/PHASE3ClinicalTrials.gov
NCT07458880HYDROCHLOROTHIAZIDEClinicalTrials.gov
NCT07372040METOLAZONEPHASE2ClinicalTrials.gov
NCT07271420CHLORTHALIDONEPHASE4ClinicalTrials.gov
NCT07271420HYDROCHLOROTHIAZIDEPHASE4ClinicalTrials.gov
NCT07259733INDAPAMIDEClinicalTrials.gov
NCT07116863CHLORTHALIDONEPHASE3ClinicalTrials.gov
NCT07064525INDAPAMIDEPHASE2ClinicalTrials.gov
NCT07020104HYDROCHLOROTHIAZIDEClinicalTrials.gov

1 to 10 of 334

See all 334 trials

NIH grants1,333

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC12A3 papersNewest fiscal year
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport522025
R01DK098141Regulation of renal ion transport by the CUL3-WNK-SPAK pathway142025
R01DK093501WNK-SPAK signaling in the Distal Nephron122025
R01DK110358Regulation of WNK signaling by potassium and Mo25: structure, function and physiology92025
R01DK110375Coordinated SLC12A3/SLC12A6/SL26A4 electroneutral transport pathways maintain K+ homeostasis and acid-base balance82025
R01DK054231Molecular of ROMK Channel Function52025
R01DK133220Role of Kir4.1 in regulating NCC and ROMK in DCT52025
R01HL147818ENaC regulation and its role in blood pressure homeostasis52025
ZIAHL001285Solute And Water Transport In Renal Epithelia52025
I01BX000893Role of M1 Cytokines in the Progression of Chronic Kidney Disease42025

1 to 10 of 1,333Source NIH's project files

See all 1,333 nih grants

Papers2,457

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Long-Standing Hypokalemia and Hypomagnesemia in a 61 Year-Old Woman: A Delayed Diagnosis of Gitelman Syndrome.Electrolyte Blood Press202642812717PubTator, text miningPubMed
Monogenic Kidney Disorders as Hidden Drivers of Electrolyte Imbalance and Hypertension.Electrolyte Blood Press202642812492PubTator, text miningPubMed
Dapagliflozin Beyond Glucose Lowering: Mechanisms of Renal and Systemic Protection.Pathophysiology202642784236PubTator, text miningPubMed
Symptom Burden and Clinical Clues in Gitelman Syndrome and Pseudo-Gitelman Syndrome.Kidney360202642776593PubTator, text miningPubMed
Symptomatic heterozygous Gitelman syndrome in a professional baseball player: a case report.J Osteopath Med202642776028PubTator, text miningPubMed
Temporal dynamics of urinary extracellular vesicle excretion and cargo in healthy subjects over 24 h.Am J Physiol Renal Physiol202642775544PubTator, text miningPubMed
Mitochondrial dysfunction drives metabolic reprogramming in Gitelman syndrome: insights from proteomics and isogenic modeling.Hum Genet202642766034PubTator, text miningPubMed
Dual-crosslinked calcium alginate/nanocrystalline cellulose bio-nanocomposite films with enhanced thermomechanical and rheological properties.Int J Biol Macromol202642748999PubTator, text miningPubMed
Late diagnosis of Gitelman syndrome in an elderly patient: identification of a novel SLC12A3 pathogenic variant.J Bras Nefrol202642743372PubTator, text miningPubMed
Perioperative management of a patient with retrosternal giant goiter and Gitelman syndrome: a case report.Front Med (Lausanne)202642718562PubTator, text miningPubMed

1 to 10 of 2,457

See all 2,457 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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