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Gene · 7067

THRA: thyroid hormone receptor alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. THRA: thyroid hormone receptor alpha. Genes, record 7067. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7067

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Gene

Symbol
THRA
HGNC
Name
thyroid hormone receptor alpha
HGNC
NCBI Gene ID
7067
NCBI Gene
HGNC ID
HGNC:11796
HGNC
Ensembl
ENSG00000126351
NCBI Gene
Aliases
AR7, CHNG6, EAR-7.1/EAR-7.2, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, THRA3, THRalpha, THRalpha1, THRalpha2, TRalpha, TRalpha1, TRalpha2, c-ERBA-1, c-erbA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10827Thyroid hormone receptor alpha49010Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086503 A2026-05-2677P10827Espacenet
JP 2026004568 A2026-01-1467078P10827Espacenet
JP 2026004568 A2026-01-1467079P10827Espacenet
JP 2025147176 A2025-10-0615785P10827Espacenet
EP 4516308 A22025-03-0577P10827Espacenet
JP 2025028160 A2025-02-2815785P10827Espacenet
KR 1020250010750 A2025-01-2115785P10827Espacenet
JP 2024109657 A2024-08-1415624P10827Espacenet
US 11993660 B22024-05-2877P10827Espacenet
JP 2024054208 A2024-04-1677P10827Espacenet

1 to 10 of 52

See all 52 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DEXTROTHYROXINECHEMBL559Thyroid hormone receptor agonistAGONISTChEMBL
DEXTROTHYROXINE SODIUMCHEMBL3545058Thyroid hormone receptor agonistAGONISTChEMBL
LEVOTHYROXINECHEMBL1624Thyroid hormone receptor agonistAGONISTChEMBL
LEVOTHYROXINE SODIUMCHEMBL2103741Thyroid hormone receptor agonistAGONISTChEMBL
LIOTHYRONINECHEMBL1544Thyroid hormone receptor agonistAGONISTChEMBL
LIOTHYRONINE SODIUMCHEMBL1201119Thyroid hormone receptor agonistAGONISTChEMBL
TIRATRICOLCHEMBL41632Thyroid hormone receptor agonistAGONISTChEMBL

Trials128

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07424183LIOTHYRONINEPHASE2ClinicalTrials.gov
NCT07424183LEVOTHYROXINE SODIUMPHASE2ClinicalTrials.gov
NCT07421869LEVOTHYROXINEClinicalTrials.gov
NCT07346157LIOTHYRONINEPHASE1/PHASE2ClinicalTrials.gov
NCT07332273LEVOTHYROXINEPHASE3ClinicalTrials.gov
NCT07239674LEVOTHYROXINEPHASE3ClinicalTrials.gov
NCT06971965LEVOTHYROXINEClinicalTrials.gov
NCT06790589LEVOTHYROXINEPHASE2ClinicalTrials.gov
NCT06757712LEVOTHYROXINEClinicalTrials.gov
NCT06731764LIOTHYRONINEPHASE2/PHASE3ClinicalTrials.gov

1 to 10 of 128

See all 128 trials

NIH grants1,018

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTHRA papersNewest fiscal year
ZIABC008752Thyroid Hormone Nuclear Receptors in Health and Disease192025
ZIABC011191Preclinical Mouse Models of Thyroid Cancer122025
U54GM115516Northern New England Clinical and Translational Research Network42025
P30CA008748Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA093373Cancer Center Support Grant P3032025
T32ES007059Advanced Training in Environmental Health Sciences32025
I01BX001966Thyroid Hormone and Neuronal Protection22025
P30CA015704Cancer Center Support Grant22025

1 to 10 of 1,018Source NIH's project files

See all 1,018 nih grants

Papers1,888

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction.Nat Metab202642827194PubTator, text miningPubMed
Targeting Nuclear Import of Thyroid Hormone Receptor Alpha with Natural Polyphenols: Potential Mechanism for Lipolysis in Metabolic Dysfunction-Associated Steatotic Liver Disease.Curr Issues Mol Biol202642793229PubTator, text miningPubMed
Functional Characterization of a Novel Variant of the Thyroid Hormone Receptor Alpha in a Child with Developmental Delay and Abnormal Thyroid Function.Thyroid202642764528PubTator, text miningPubMed
Pharmacologic management of metabolic and alcohol-associated liver disease.Metab Target Organ Damage202642577825PubTator, text miningPubMed
Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha-Fatty-Acid Amide Hydrolase 1 Signaling Pathway.MedComm (2020)202642558980PubTator, text miningPubMed
Cell composition, transcriptomic, and functional pathway changes in the hippocampus in Alzheimer's disease and overlap with lead (Pb) exposure signatures.medRxiv202642539046PubTator, text miningPubMed
Intrafamilial and Age-Dependent Variability in Resistance to Thyroid Hormone Alpha: A Case Report.Horm Res Paediatr202642301959PubTator, text miningPubMed
IL-33 accelerates orthodontic tooth movement by promoting M1 differentiation of macrophages and osteoclast formation.Sci Rep202642277334PubTator, text miningPubMed
Epigenomic regulation of neural crest differentiation in human-induced pluripotent stem cells.iScience202642231962PubTator, text miningPubMed
Effect of monochromatic light combinations on muscle fiber types in broilers after thyroidectomy.Poult Sci202642184629PubTator, text miningPubMed

1 to 10 of 1,888

See all 1,888 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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