Gene · 7067
THRA: thyroid hormone receptor alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. THRA: thyroid hormone receptor alpha. Genes, record 7067. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7067
On this page
Gene
- Aliases
- AR7, CHNG6, EAR-7.1/EAR-7.2, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, THRA3, THRalpha, THRalpha1, THRalpha2, TRalpha, TRalpha1, TRalpha2, c-ERBA-1, c-erbA
- NCBI Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P10827 | Thyroid hormone receptor alpha | 490 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents52
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026086503 A | 2026-05-26 | 77 | P10827 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67078 | P10827 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67079 | P10827 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15785 | P10827 | Espacenet |
| EP 4516308 A2 | 2025-03-05 | 77 | P10827 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15785 | P10827 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15785 | P10827 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15624 | P10827 | Espacenet |
| US 11993660 B2 | 2024-05-28 | 77 | P10827 | Espacenet |
| JP 2024054208 A | 2024-04-16 | 77 | P10827 | Espacenet |
1 to 10 of 52
See all 52 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DEXTROTHYROXINE | CHEMBL559 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
| DEXTROTHYROXINE SODIUM | CHEMBL3545058 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
| LEVOTHYROXINE | CHEMBL1624 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
| LEVOTHYROXINE SODIUM | CHEMBL2103741 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
| LIOTHYRONINE | CHEMBL1544 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
| LIOTHYRONINE SODIUM | CHEMBL1201119 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
| TIRATRICOL | CHEMBL41632 | Thyroid hormone receptor agonist | AGONIST | ChEMBL |
Trials128
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07424183 | LIOTHYRONINE | PHASE2 | ClinicalTrials.gov | |
| NCT07424183 | LEVOTHYROXINE SODIUM | PHASE2 | ClinicalTrials.gov | |
| NCT07421869 | LEVOTHYROXINE | ClinicalTrials.gov | ||
| NCT07346157 | LIOTHYRONINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07332273 | LEVOTHYROXINE | PHASE3 | ClinicalTrials.gov | |
| NCT07239674 | LEVOTHYROXINE | PHASE3 | ClinicalTrials.gov | |
| NCT06971965 | LEVOTHYROXINE | ClinicalTrials.gov | ||
| NCT06790589 | LEVOTHYROXINE | PHASE2 | ClinicalTrials.gov | |
| NCT06757712 | LEVOTHYROXINE | ClinicalTrials.gov | ||
| NCT06731764 | LIOTHYRONINE | PHASE2/PHASE3 | ClinicalTrials.gov |
1 to 10 of 128
See all 128 trialsNIH grants1,018
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | THRA papers | Newest fiscal year |
|---|---|---|---|
| ZIABC008752 | Thyroid Hormone Nuclear Receptors in Health and Disease | 19 | 2025 |
| ZIABC011191 | Preclinical Mouse Models of Thyroid Cancer | 12 | 2025 |
| U54GM115516 | Northern New England Clinical and Translational Research Network | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 3 | 2025 |
| T32ES007059 | Advanced Training in Environmental Health Sciences | 3 | 2025 |
| I01BX001966 | Thyroid Hormone and Neuronal Protection | 2 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,018Source NIH's project files
See all 1,018 nih grantsPapers1,888
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction. | Nat Metab | 2026 | 42827194 | PubTator, text mining | PubMed |
| Targeting Nuclear Import of Thyroid Hormone Receptor Alpha with Natural Polyphenols: Potential Mechanism for Lipolysis in Metabolic Dysfunction-Associated Steatotic Liver Disease. | Curr Issues Mol Biol | 2026 | 42793229 | PubTator, text mining | PubMed |
| Functional Characterization of a Novel Variant of the Thyroid Hormone Receptor Alpha in a Child with Developmental Delay and Abnormal Thyroid Function. | Thyroid | 2026 | 42764528 | PubTator, text mining | PubMed |
| Pharmacologic management of metabolic and alcohol-associated liver disease. | Metab Target Organ Damage | 2026 | 42577825 | PubTator, text mining | PubMed |
| Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha-Fatty-Acid Amide Hydrolase 1 Signaling Pathway. | MedComm (2020) | 2026 | 42558980 | PubTator, text mining | PubMed |
| Cell composition, transcriptomic, and functional pathway changes in the hippocampus in Alzheimer's disease and overlap with lead (Pb) exposure signatures. | medRxiv | 2026 | 42539046 | PubTator, text mining | PubMed |
| Intrafamilial and Age-Dependent Variability in Resistance to Thyroid Hormone Alpha: A Case Report. | Horm Res Paediatr | 2026 | 42301959 | PubTator, text mining | PubMed |
| IL-33 accelerates orthodontic tooth movement by promoting M1 differentiation of macrophages and osteoclast formation. | Sci Rep | 2026 | 42277334 | PubTator, text mining | PubMed |
| Epigenomic regulation of neural crest differentiation in human-induced pluripotent stem cells. | iScience | 2026 | 42231962 | PubTator, text mining | PubMed |
| Effect of monochromatic light combinations on muscle fiber types in broilers after thyroidectomy. | Poult Sci | 2026 | 42184629 | PubTator, text mining | PubMed |
1 to 10 of 1,888
See all 1,888 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7067
GET https://conductscience.org/api/genes/v1/7067/patents?page=2