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Gene · 7068

THRB: thyroid hormone receptor beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. THRB: thyroid hormone receptor beta. Genes, record 7068. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7068

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Gene

Symbol
THRB
HGNC
Name
thyroid hormone receptor beta
HGNC
NCBI Gene ID
7068
NCBI Gene
HGNC ID
HGNC:11799
HGNC
Ensembl
ENSG00000151090
NCBI Gene
Aliases
C-ERBA-2, C-ERBA-BETA, ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, THRbeta, THRbeta1, TRb, TRbeta, TRbeta1, Thrbeta2, c-erbA-2, c-erbA-beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10828Thyroid hormone receptor beta46134Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467082P10828Espacenet
JP 2026004568 A2026-01-1467083P10828Espacenet
JP 2026004568 A2026-01-1467084P10828Espacenet
EP 4641201 A22025-10-297249P10828Espacenet
JP 2025147176 A2025-10-0615786P10828Espacenet
JP 2025517969 A2025-06-127249P10828Espacenet
JP 2025028160 A2025-02-2815786P10828Espacenet
KR 1020250010750 A2025-01-2115786P10828Espacenet
JP 2024109657 A2024-08-1415625P10828Espacenet
US 11446398 B22022-09-2088812P10828Espacenet

1 to 10 of 48

See all 48 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DEXTROTHYROXINECHEMBL559Thyroid hormone receptor agonistAGONISTChEMBL
DEXTROTHYROXINE SODIUMCHEMBL3545058Thyroid hormone receptor agonistAGONISTChEMBL
EPROTIROMECHEMBL2035874Thyroid hormone receptor beta-1 agonistAGONISTChEMBL
LEVOTHYROXINECHEMBL1624Thyroid hormone receptor agonistAGONISTChEMBL
LEVOTHYROXINE SODIUMCHEMBL2103741Thyroid hormone receptor agonistAGONISTChEMBL
LIOTHYRONINECHEMBL1544Thyroid hormone receptor agonistAGONISTChEMBL
LIOTHYRONINE SODIUMCHEMBL1201119Thyroid hormone receptor agonistAGONISTChEMBL
MB07811CHEMBL471897Thyroid hormone receptor beta-1 agonistAGONISTChEMBL
RESMETIROMCHEMBL3261331Thyroid hormone receptor beta-1 agonistAGONISTChEMBL
TIRATRICOLCHEMBL41632Thyroid hormone receptor agonistAGONISTChEMBL

Trials141

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07424183LIOTHYRONINEPHASE2ClinicalTrials.gov
NCT07424183LEVOTHYROXINE SODIUMPHASE2ClinicalTrials.gov
NCT07421869LEVOTHYROXINEClinicalTrials.gov
NCT07346157LIOTHYRONINEPHASE1/PHASE2ClinicalTrials.gov
NCT07335601RESMETIROMPHASE2ClinicalTrials.gov
NCT07332273LEVOTHYROXINEPHASE3ClinicalTrials.gov
NCT07239674LEVOTHYROXINEPHASE3ClinicalTrials.gov
NCT07143968RESMETIROMPHASE2ClinicalTrials.gov
NCT06971965LEVOTHYROXINEClinicalTrials.gov
NCT06790589LEVOTHYROXINEPHASE2ClinicalTrials.gov

1 to 10 of 141

See all 141 trials

NIH grants1,517

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTHRB papersNewest fiscal year
R01DK015070Thyroid Physiology Studies of Inherited Disorders312025
ZIABC011191Preclinical Mouse Models of Thyroid Cancer292025
ZIABC008752Thyroid Hormone Nuclear Receptors in Health and Disease252025
U54GM115516Northern New England Clinical and Translational Research Network102025
P30CA016058Cancer Center Support Grant92025
P30DK120515San Diego Digestive Diseases Research Center62025
P30CA008748Cancer Center Support Grant52025
R01CA137124Production and progression of premalignant retinoblastoma lesions.52025
R01DK043806Integrative Physiology of Thyroid Hormone Receptors and Nuclear Receptor Corepressors52025
T32DK007011Integrated Clinical and Basic Endocrinology Research52025

1 to 10 of 1,517Source NIH's project files

See all 1,517 nih grants

Papers3,032

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[New Therapeutic Approaches for MASH: Mechanisms and Clinical Promise].Z Gastroenterol202642777699PubTator, text miningPubMed
Reporter-guided photoreceptor differentiation in 2D culture using PGP1-hIPSCs: A comparable alternative to 3D organoid systems?Mol Vis202642774032PubTator, text miningPubMed
Combination pharmacotherapy for MASH: Potential synergistic approaches.Biochem Pharmacol202642767573PubTator, text miningPubMed
Evaluation of the Immortalized Primary Human Hepatocyte Cell Line Fa2N-4 as a Model for Metabolic Dysfunction-Associated Steatotic Liver Disease.Gastro Hep Adv202642755934PubTator, text miningPubMed
Prime editing models the MTARC1 A165T variant in human liver organoids, demonstrating reduced steatosis, inflammation, and fibrosis.Hepatol Commun202642748411PubTator, text miningPubMed
MYC-regulated long non-coding RNA SNHG1 controls S-phase kinase-associated protein 2-mediated p21 protein stability under thyroid hormone receptor signaling in hepatocellular carcinoma.Int J Biol Macromol202642735764PubTator, text miningPubMed
Hypothyroidism and Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms, Clinical Links, and Therapeutic Implications.Curr Obes Rep202642734707PubTator, text miningPubMed
International expert panel review for the use of resmetirom and semaglutide in the management of MASH-related fibrosis: clinical practice update.Gut202642728029PubTator, text miningPubMed
The role of thyroid hormone receptor beta 1 (THRβ1) in metabolic dysfunction associated steatohepatitis (MASH): from dysregulation to therapeutic target.Biochem Pharmacol202642710788PubTator, text miningPubMed
Current therapeutic landscape and future treatment perspectives of MASH.Nature202642687024PubTator, text miningPubMed

1 to 10 of 3,032

See all 3,032 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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