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Gene · 7166

TPH1: tryptophan hydroxylase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPH1: tryptophan hydroxylase 1. Genes, record 7166. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7166

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Gene

Symbol
TPH1
HGNC
Name
tryptophan hydroxylase 1
HGNC
NCBI Gene ID
7166
NCBI Gene
HGNC ID
HGNC:12008
HGNC
Ensembl
ENSG00000129167
NCBI Gene
Aliases
TPH, TPRH, TRPH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17752Tryptophan 5-hydroxylase 144421Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468405P17752Espacenet
EP 4641201 A22025-10-29924P17752Espacenet
JP 2025517969 A2025-06-12924P17752Espacenet
US 11866749 B22024-01-092P17752Espacenet
JP 2023519296 A2023-05-1069P17752Espacenet
US 11446398 B22022-09-2093130P17752Espacenet
JP 2022524081 A2022-04-27196101P17752Espacenet
US 11278549 B22022-03-221P17752Espacenet
US 11078247 B22021-08-0311894P17752Espacenet
US 11060063 B22021-07-13103P17752Espacenet

1 to 10 of 27

See all 27 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
RODATRISTAT ETHYLCHEMBL4069704Tryptophan 5-hydroxylase 1 inhibitorINHIBITORChEMBL
TELOTRISTATCHEMBL2103855Tryptophan 5-hydroxylase inhibitorINHIBITORChEMBL
TELOTRISTAT ETHYLCHEMBL2105695Tryptophan 5-hydroxylase inhibitorINHIBITORChEMBL
TELOTRISTAT ETIPRATECHEMBL3348963Tryptophan 5-hydroxylase inhibitorINHIBITORChEMBL

Trials15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04810091TELOTRISTAT ETHYLPHASE32026-02-05ClinicalTrials.gov
NCT04776876TELOTRISTAT ETHYLPHASE2ClinicalTrials.gov
NCT04713202TELOTRISTAT ETHYLPHASE2ClinicalTrials.gov
NCT04712669RODATRISTAT ETHYLPHASE22025-06-04ClinicalTrials.gov
NCT04543955TELOTRISTATPHASE22023-06-27ClinicalTrials.gov
NCT04065165TELOTRISTAT ETHYLPHASE3ClinicalTrials.gov
NCT04034745TELOTRISTAT ETHYLClinicalTrials.gov
NCT03910387TELOTRISTAT ETHYLPHASE22025-12-16ClinicalTrials.gov
NCT03790111TELOTRISTAT ETHYLPHASE22023-04-19ClinicalTrials.gov
NCT03453489TELOTRISTATPHASE22025-04-10ClinicalTrials.gov

1 to 10 of 15

See all 15 trials

NIH grants1,370

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPH1 papersNewest fiscal year
P40OD010440Caenorhabditis Genetics Center172025
ZIAMH002843Identification of Genes Involved in Major Mood Disorders62025
UL1TR001863Yale Clinical and Translational Science Award52025
ZIAAA000301Integrative genetics of behavior with high throughput technologies52025
P30CA016672Cancer Center Support Grant42025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology42025
R01DK114233Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells42025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32025
IK6BX004601BLR&D Research Career Scientist Award32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025

1 to 10 of 1,370Source NIH's project files

See all 1,370 nih grants

Papers2,118

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Intestinal Epithelial-Protective Effects of Leuconostoc mesenteroides H40 in LPS-Stimulated HT-29 Cells.J Microbiol Biotechnol202642770193PubTator, text miningPubMed
Targeting tryptophan hydroxylase 1 restricts growth and suppresses plasticity in neuroendocrine prostate cancer.J Clin Invest202642752508PubTator, text miningPubMed
A pulmonary innate lymphoid cell-driven serotonergic neuroimmune axis orchestrates airway hyperreactivity and cough hypersensitivity.Immunity202642705228PubTator, text miningPubMed
Proteomic analysis reveals a metabolic switch and cellular remodelling in pancreatic-like cell spheroids cocultured with hepatocyte-like cells using an interconnected liver-pancreas-on-chip system.Mol Omics202642644453PubTator, text miningPubMed
Genetic evidence for a causal relationship between melatonin metabolism and depression.J Affect Disord202642532281PubTator, text miningPubMed
T peripheral helper 1 cells effectively drive atypical double-negative CD11chi B cells to antibody-secreting cells and play a pathogenic role in systemic lupus erythematosus.Clin Immunol202642447945PubTator, text miningPubMed
Astragaloside IV Alleviates DSS-Induced Ulcerative Colitis by Modulating Host-Gut Tryptophan Metabolism.Foods202642195848PubTator, text miningPubMed
Plasma Tryptophan Hydroxylase 1 Activity-related Metabolic Markers and Stroke Risk: A Nested Case-control Study.Transl Stroke Res202642033575PubTator, text miningPubMed
Anisotropic excipient-free buccal wafer engineered by directional freezing for structure-guided neuro-immune therapy against chemotherapy-induced emesis.Acta Biomater202642002060PubTator, text miningPubMed
Genotype-stratified Default Mode Network hyperconnectivity in major depressive disorder: an MR imaging genetics study.J Affect Disord202641956213PubTator, text miningPubMed

1 to 10 of 2,118

See all 2,118 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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