Gene · 7166
TPH1: tryptophan hydroxylase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TPH1: tryptophan hydroxylase 1. Genes, record 7166. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7166
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17752 | Tryptophan 5-hydroxylase 1 | 444 | 21 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68405 | P17752 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 924 | P17752 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 924 | P17752 | Espacenet |
| US 11866749 B2 | 2024-01-09 | 2 | P17752 | Espacenet |
| JP 2023519296 A | 2023-05-10 | 69 | P17752 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 93130 | P17752 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 196101 | P17752 | Espacenet |
| US 11278549 B2 | 2022-03-22 | 1 | P17752 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11894 | P17752 | Espacenet |
| US 11060063 B2 | 2021-07-13 | 103 | P17752 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| RODATRISTAT ETHYL | CHEMBL4069704 | Tryptophan 5-hydroxylase 1 inhibitor | INHIBITOR | ChEMBL |
| TELOTRISTAT | CHEMBL2103855 | Tryptophan 5-hydroxylase inhibitor | INHIBITOR | ChEMBL |
| TELOTRISTAT ETHYL | CHEMBL2105695 | Tryptophan 5-hydroxylase inhibitor | INHIBITOR | ChEMBL |
| TELOTRISTAT ETIPRATE | CHEMBL3348963 | Tryptophan 5-hydroxylase inhibitor | INHIBITOR | ChEMBL |
Trials15
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04810091 | TELOTRISTAT ETHYL | PHASE3 | 2026-02-05 | ClinicalTrials.gov |
| NCT04776876 | TELOTRISTAT ETHYL | PHASE2 | ClinicalTrials.gov | |
| NCT04713202 | TELOTRISTAT ETHYL | PHASE2 | ClinicalTrials.gov | |
| NCT04712669 | RODATRISTAT ETHYL | PHASE2 | 2025-06-04 | ClinicalTrials.gov |
| NCT04543955 | TELOTRISTAT | PHASE2 | 2023-06-27 | ClinicalTrials.gov |
| NCT04065165 | TELOTRISTAT ETHYL | PHASE3 | ClinicalTrials.gov | |
| NCT04034745 | TELOTRISTAT ETHYL | ClinicalTrials.gov | ||
| NCT03910387 | TELOTRISTAT ETHYL | PHASE2 | 2025-12-16 | ClinicalTrials.gov |
| NCT03790111 | TELOTRISTAT ETHYL | PHASE2 | 2023-04-19 | ClinicalTrials.gov |
| NCT03453489 | TELOTRISTAT | PHASE2 | 2025-04-10 | ClinicalTrials.gov |
1 to 10 of 15
See all 15 trialsNIH grants1,370
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TPH1 papers | Newest fiscal year |
|---|---|---|---|
| P40OD010440 | Caenorhabditis Genetics Center | 17 | 2025 |
| ZIAMH002843 | Identification of Genes Involved in Major Mood Disorders | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 4 | 2025 |
| R01DK114233 | Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells | 4 | 2025 |
| I01BX004293 | CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer | 3 | 2025 |
| IK6BX004601 | BLR&D Research Career Scientist Award | 3 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 3 | 2025 |
1 to 10 of 1,370Source NIH's project files
See all 1,370 nih grantsPapers2,118
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Intestinal Epithelial-Protective Effects of Leuconostoc mesenteroides H40 in LPS-Stimulated HT-29 Cells. | J Microbiol Biotechnol | 2026 | 42770193 | PubTator, text mining | PubMed |
| Targeting tryptophan hydroxylase 1 restricts growth and suppresses plasticity in neuroendocrine prostate cancer. | J Clin Invest | 2026 | 42752508 | PubTator, text mining | PubMed |
| A pulmonary innate lymphoid cell-driven serotonergic neuroimmune axis orchestrates airway hyperreactivity and cough hypersensitivity. | Immunity | 2026 | 42705228 | PubTator, text mining | PubMed |
| Proteomic analysis reveals a metabolic switch and cellular remodelling in pancreatic-like cell spheroids cocultured with hepatocyte-like cells using an interconnected liver-pancreas-on-chip system. | Mol Omics | 2026 | 42644453 | PubTator, text mining | PubMed |
| Genetic evidence for a causal relationship between melatonin metabolism and depression. | J Affect Disord | 2026 | 42532281 | PubTator, text mining | PubMed |
| T peripheral helper 1 cells effectively drive atypical double-negative CD11chi B cells to antibody-secreting cells and play a pathogenic role in systemic lupus erythematosus. | Clin Immunol | 2026 | 42447945 | PubTator, text mining | PubMed |
| Astragaloside IV Alleviates DSS-Induced Ulcerative Colitis by Modulating Host-Gut Tryptophan Metabolism. | Foods | 2026 | 42195848 | PubTator, text mining | PubMed |
| Plasma Tryptophan Hydroxylase 1 Activity-related Metabolic Markers and Stroke Risk: A Nested Case-control Study. | Transl Stroke Res | 2026 | 42033575 | PubTator, text mining | PubMed |
| Anisotropic excipient-free buccal wafer engineered by directional freezing for structure-guided neuro-immune therapy against chemotherapy-induced emesis. | Acta Biomater | 2026 | 42002060 | PubTator, text mining | PubMed |
| Genotype-stratified Default Mode Network hyperconnectivity in major depressive disorder: an MR imaging genetics study. | J Affect Disord | 2026 | 41956213 | PubTator, text mining | PubMed |
1 to 10 of 2,118
See all 2,118 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7166
GET https://conductscience.org/api/genes/v1/7166/patents?page=2