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Gene · 9356

SLC22A6: solute carrier family 22 member 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC22A6: solute carrier family 22 member 6. Genes, record 9356. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9356

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Gene

Symbol
SLC22A6
HGNC
Name
solute carrier family 22 member 6
HGNC
NCBI Gene ID
9356
NCBI Gene
HGNC ID
HGNC:10970
HGNC
Ensembl
ENSG00000197901
NCBI Gene
Aliases
HOAT1, OAT1, PAHT, ROAT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q4U2R8Solute carrier family 22 member 656312Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464167Q4U2R8Espacenet
EP 4641201 A22025-10-2910247Q4U2R8Espacenet
JP 2025529142 A2025-09-044064Q4U2R8Espacenet
US 12371689 B22025-07-294064Q4U2R8Espacenet
JP 2025517969 A2025-06-1210247Q4U2R8Espacenet
JP 2025032204 A2025-03-1135836Q4U2R8Espacenet
EP 4461818 A22024-11-1335836Q4U2R8Espacenet
JP 2023058610 A2023-04-2535836Q4U2R8Espacenet
US 11446398 B22022-09-2080742Q4U2R8Espacenet
US 11400116 B22022-08-023127Q4U2R8Espacenet

1 to 10 of 31

See all 31 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PRATOSARTANCHEMBL41194Solute carrier family 22 member 6 inhibitorINHIBITORChEMBL
PROBENECIDCHEMBL897Solute carrier family 22 member 6 inhibitorINHIBITORChEMBL

Trials16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07118618PROBENECIDPHASE2ClinicalTrials.gov
NCT07092813PROBENECIDPHASE1ClinicalTrials.gov
NCT05903859PROBENECIDPHASE3ClinicalTrials.gov
NCT05442983PROBENECIDPHASE2ClinicalTrials.gov
NCT04551222PROBENECIDPHASE2/PHASE3ClinicalTrials.gov
NCT04218357PROBENECIDPHASE12025-02-27ClinicalTrials.gov
NCT03357614PROBENECIDPHASE32020-12-29ClinicalTrials.gov
NCT02243631PROBENECIDEARLY_PHASE12022-07-26ClinicalTrials.gov
NCT01816646PROBENECIDPHASE1ClinicalTrials.gov
NCT01320722PROBENECIDPHASE32017-06-29ClinicalTrials.gov

1 to 10 of 16

See all 16 trials

NIH grants952

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC22A6 papersNewest fiscal year
R01DK109392The Role in OAT1 in Uremia152025
P30AI050410The University of North Carolina Center for AIDS Research102025
P30ES006694Southwest Environmental Health Sciences Center102025
R01AI077505Pharmacogenomics of HIV Therapy62025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)52025
T32EB009380Training in Multi-scale Analysis of Biological Structure and Function52025
P30CA016058Cancer Center Support Grant42025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment42025
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation42025

1 to 10 of 952Source NIH's project files

See all 952 nih grants

Papers1,877

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transport of Perfluoroalkyl Substances (PFAS) by Three Renal Transporters: Implications for PFAS Bioaccumulation Mechanisms.Environ Health (Wash)202642775203PubTator, text miningPubMed
Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults.J Clin Hypertens (Greenwich)202642745169PubTator, text miningPubMed
Urine-to-Blood Partitioning of Per- and Polyfluoroalkyl Substances in Human Biomonitoring: Implications for Environmental Exposure Analysis and Bioaccumulation Assessment.Molecules202642280183PubTator, text miningPubMed
Preclinical Evaluation of 5F-αMe-3BPA for Improving Pharmacokinetics in Boron Neutron Capture Therapy.Pharmaceutics202642198297PubTator, text miningPubMed
Regulation of Human Renal Transporters by Pregnancy-Related Hormones in Primary Proximal Tubular Epithelial Cells.Metabolites202642188001PubTator, text miningPubMed
Transition to fetal calf serum-free culture enhances kidney proximal tubule cell bioenergetics and allows pharmacological applications.Cell Tissue Res202642174256PubTator, text miningPubMed
Enhanced anti-hyperuricemic effect of Simiao pill by composite lactic acid bacteria fermentation: ferulic acid and berberine enrichment and URAT1/OAT1/XOD regulation.Front Pharmacol202642147310PubTator, text miningPubMed
Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study.Clin Pharmacol Ther202642116706PubTator, text miningPubMed
High-Altitude Hypoxia Dysregulates the Organic Anion Transport Network to Alter Acetazolamide Disposition and Renal Metabolic Homeostasis: Validation of the Remote Sensing and Signaling Theory.Drug Metab Dispos202642096976PubTator, text miningPubMed
MegaTrans-machine learning models for drug transporters corresponding to the FDA guidance.Drug Metab Dispos202642090811PubTator, text miningPubMed

1 to 10 of 1,877

See all 1,877 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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