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Gene · 9376

SLC22A8: solute carrier family 22 member 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC22A8: solute carrier family 22 member 8. Genes, record 9376. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9376

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Gene

Symbol
SLC22A8
HGNC
Name
solute carrier family 22 member 8
HGNC
NCBI Gene ID
9376
NCBI Gene
HGNC ID
HGNC:10972
HGNC
Ensembl
ENSG00000149452
NCBI Gene
Aliases
OAT3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TCC7Organic anion transporter 35420Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464177Q8TCC7Espacenet
JP 2026004568 A2026-01-1464178Q8TCC7Espacenet
EP 4641201 A22025-10-296030Q8TCC7Espacenet
JP 2025529142 A2025-09-044066Q8TCC7Espacenet
US 12371689 B22025-07-294066Q8TCC7Espacenet
JP 2025517969 A2025-06-126030Q8TCC7Espacenet
JP 2025032204 A2025-03-1135839Q8TCC7Espacenet
JP 2025032204 A2025-03-1135843Q8TCC7Espacenet
EP 4461818 A22024-11-1335839Q8TCC7Espacenet
EP 4461818 A22024-11-1335843Q8TCC7Espacenet

1 to 10 of 35

See all 35 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PRATOSARTANCHEMBL41194Solute carrier family 22 member 8 inhibitorINHIBITORChEMBL
PROBENECIDCHEMBL897Solute carrier family 22 member 8 inhibitorINHIBITORChEMBL

Trials16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07118618PROBENECIDPHASE2ClinicalTrials.gov
NCT07092813PROBENECIDPHASE1ClinicalTrials.gov
NCT05903859PROBENECIDPHASE3ClinicalTrials.gov
NCT05442983PROBENECIDPHASE2ClinicalTrials.gov
NCT04551222PROBENECIDPHASE2/PHASE3ClinicalTrials.gov
NCT04218357PROBENECIDPHASE12025-02-27ClinicalTrials.gov
NCT03357614PROBENECIDPHASE32020-12-29ClinicalTrials.gov
NCT02243631PROBENECIDEARLY_PHASE12022-07-26ClinicalTrials.gov
NCT01816646PROBENECIDPHASE1ClinicalTrials.gov
NCT01320722PROBENECIDPHASE32017-06-29ClinicalTrials.gov

1 to 10 of 16

See all 16 trials

NIH grants883

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC22A8 papersNewest fiscal year
R01DK109392The Role in OAT1 in Uremia152025
P30ES006694Southwest Environmental Health Sciences Center142025
P30CA021765Cancer Center Support Grant (CCSG)92025
P30AI050410The University of North Carolina Center for AIDS Research72025
R35GM122576Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy72025
T32ES007091Training in Environmental Toxicology of Human Disease62025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)52025
R01AI077505Pharmacogenomics of HIV Therapy52025
T32GM007546Clinical Pharmacology, Drug Action and Pharmacogenetics52025
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation42025

1 to 10 of 883Source NIH's project files

See all 883 nih grants

Papers2,037

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
In vitro assessments for pharmacokinetic drug-drug interaction potential of vornorexant, a novel dual orexin 1/2 receptor antagonist.Xenobiotica202642693680PubTator, text miningPubMed
Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study.CPT Pharmacometrics Syst Pharmacol202642681799PubTator, text miningPubMed
Urine-to-Blood Partitioning of Per- and Polyfluoroalkyl Substances in Human Biomonitoring: Implications for Environmental Exposure Analysis and Bioaccumulation Assessment.Molecules202642280183PubTator, text miningPubMed
Altered renal disposition of adefovir in metabolic dysfunction-associated steatohepatitis using the fast-food diet and thioacetamide-induced model to extrapolate renal secretion.Drug Metab Dispos202642208114PubTator, text miningPubMed
Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study.Clin Pharmacol Ther202642116706PubTator, text miningPubMed
MegaTrans-machine learning models for drug transporters corresponding to the FDA guidance.Drug Metab Dispos202642090811PubTator, text miningPubMed
Bempedoic acid and increased serum uric acid levels: a matter of concern?Nutr Metab Cardiovasc Dis202642070947PubTator, text miningPubMed
Simulating the interactions between per- and polyfluoroalkyl substances and kidney transporters for understanding their half-life and renal bioaccumulation.Chem Biol Interact202642019661PubTator, text miningPubMed
Flavonoid Interactions with Renal Organic Anion Transporters OAT1 and OAT3: Structure-Activity Relationships and Clinical Implications.Int J Mol Sci202641977489PubTator, text miningPubMed
Ochratoxin A and Clear Cell Renal Cell Carcinoma: Exploring Potential Molecular Links Through Network Toxicology and Machine Learning.Int J Mol Sci202641977161PubTator, text miningPubMed

1 to 10 of 2,037

See all 2,037 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9376

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