Gene · 9376
SLC22A8: solute carrier family 22 member 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC22A8: solute carrier family 22 member 8. Genes, record 9376. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9376
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TCC7 | Organic anion transporter 3 | 542 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64177 | Q8TCC7 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 64178 | Q8TCC7 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6030 | Q8TCC7 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4066 | Q8TCC7 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4066 | Q8TCC7 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6030 | Q8TCC7 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35839 | Q8TCC7 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35843 | Q8TCC7 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35839 | Q8TCC7 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35843 | Q8TCC7 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials16
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07118618 | PROBENECID | PHASE2 | ClinicalTrials.gov | |
| NCT07092813 | PROBENECID | PHASE1 | ClinicalTrials.gov | |
| NCT05903859 | PROBENECID | PHASE3 | ClinicalTrials.gov | |
| NCT05442983 | PROBENECID | PHASE2 | ClinicalTrials.gov | |
| NCT04551222 | PROBENECID | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT04218357 | PROBENECID | PHASE1 | 2025-02-27 | ClinicalTrials.gov |
| NCT03357614 | PROBENECID | PHASE3 | 2020-12-29 | ClinicalTrials.gov |
| NCT02243631 | PROBENECID | EARLY_PHASE1 | 2022-07-26 | ClinicalTrials.gov |
| NCT01816646 | PROBENECID | PHASE1 | ClinicalTrials.gov | |
| NCT01320722 | PROBENECID | PHASE3 | 2017-06-29 | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsNIH grants883
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC22A8 papers | Newest fiscal year |
|---|---|---|---|
| R01DK109392 | The Role in OAT1 in Uremia | 15 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 14 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 9 | 2025 |
| P30AI050410 | The University of North Carolina Center for AIDS Research | 7 | 2025 |
| R35GM122576 | Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy | 7 | 2025 |
| T32ES007091 | Training in Environmental Toxicology of Human Disease | 6 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 5 | 2025 |
| R01AI077505 | Pharmacogenomics of HIV Therapy | 5 | 2025 |
| T32GM007546 | Clinical Pharmacology, Drug Action and Pharmacogenetics | 5 | 2025 |
| P42ES004940 | The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation | 4 | 2025 |
1 to 10 of 883Source NIH's project files
See all 883 nih grantsPapers2,037
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| In vitro assessments for pharmacokinetic drug-drug interaction potential of vornorexant, a novel dual orexin 1/2 receptor antagonist. | Xenobiotica | 2026 | 42693680 | PubTator, text mining | PubMed |
| Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study. | CPT Pharmacometrics Syst Pharmacol | 2026 | 42681799 | PubTator, text mining | PubMed |
| Urine-to-Blood Partitioning of Per- and Polyfluoroalkyl Substances in Human Biomonitoring: Implications for Environmental Exposure Analysis and Bioaccumulation Assessment. | Molecules | 2026 | 42280183 | PubTator, text mining | PubMed |
| Altered renal disposition of adefovir in metabolic dysfunction-associated steatohepatitis using the fast-food diet and thioacetamide-induced model to extrapolate renal secretion. | Drug Metab Dispos | 2026 | 42208114 | PubTator, text mining | PubMed |
| Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study. | Clin Pharmacol Ther | 2026 | 42116706 | PubTator, text mining | PubMed |
| MegaTrans-machine learning models for drug transporters corresponding to the FDA guidance. | Drug Metab Dispos | 2026 | 42090811 | PubTator, text mining | PubMed |
| Bempedoic acid and increased serum uric acid levels: a matter of concern? | Nutr Metab Cardiovasc Dis | 2026 | 42070947 | PubTator, text mining | PubMed |
| Simulating the interactions between per- and polyfluoroalkyl substances and kidney transporters for understanding their half-life and renal bioaccumulation. | Chem Biol Interact | 2026 | 42019661 | PubTator, text mining | PubMed |
| Flavonoid Interactions with Renal Organic Anion Transporters OAT1 and OAT3: Structure-Activity Relationships and Clinical Implications. | Int J Mol Sci | 2026 | 41977489 | PubTator, text mining | PubMed |
| Ochratoxin A and Clear Cell Renal Cell Carcinoma: Exploring Potential Molecular Links Through Network Toxicology and Machine Learning. | Int J Mol Sci | 2026 | 41977161 | PubTator, text mining | PubMed |
1 to 10 of 2,037
See all 2,037 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9376
GET https://conductscience.org/api/genes/v1/9376/patents?page=2