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Paper · 111146

A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation.

Seidman JG and 2 others. Nature, 1979. Cited by 275 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Papers, record 111146. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/111146

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation.
PubMed
Journal
Nature
PubMed
Year
1979
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
275
iCite
Relative citation ratio, by iCite
5.19
iCite
Revised in PubMed
2026-10-10
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Seidman JGJ G
2Max EEE E
3Leder PP

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GenesMajor topic
Immunoglobulin Light ChainsMajor topic
Immunoglobulin kappa-ChainsMajor topic
Recombination, GeneticMajor topic
Animals
Antibody Specificity
Base Sequence
Immunoglobulin Constant Regions
Immunoglobulin Variable Region
Mice
Mutation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1103,004The arrangement and rearrangement of antibody genes.Nature1978https://conductscience.org/library/papers/103004PubMed
2408,080Genetic control of antibody variable regions.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/408080PubMed
3105,355DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/105355PubMed
44,162,931Mechanism of antibody synthesis: size differences between mouse kappa chains.Science1967https://conductscience.org/library/papers/4162931PubMed
5415,308Immunoglobulin light chain mRNA is processed from large nuclear RNA.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/415308PubMed
64,160,200The molecular basis of antibody formation: a paradox.Proc Natl Acad Sci U S A1965https://conductscience.org/library/papers/4160200PubMed
7115,000Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/115000PubMed
8414,842Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA.Cell1978https://conductscience.org/library/papers/414842PubMed
9322,278EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system.Science1977https://conductscience.org/library/papers/322278PubMed
10824,647Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/824647PubMed

1 to 10 of 31

See all 31 references

Cited by107

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 275 citations.

PMIDTitleJournalYearIn PapersSource
39,757,641Protein Misfolding and Aggregation of Pathological IgG Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications.Curr Protein Pept Sci2025https://conductscience.org/library/papers/39757641PubMed
33,854,505Spatial Organization of Chromatin: Transcriptional Control of Adaptive Immune Cell Development.Front Immunol2021https://conductscience.org/library/papers/33854505PubMed
10,837,051Receptor selection in B and T lymphocytes.Annu Rev Immunol2000https://conductscience.org/library/papers/10837051PubMed
8,550,098Rapid cloning of any rearranged mouse immunoglobulin variable genes.Immunogenetics1996https://conductscience.org/library/papers/8550098PubMed
8,478,611Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.J Exp Med1993https://conductscience.org/library/papers/8478611PubMed
8,208,601Conservation of sequence in recombination signal sequence spacers.Nucleic Acids Res1994https://conductscience.org/library/papers/8208601PubMed
7,019,666Species nonspecific fraction of non-histone chromatin proteins in mice and rats immunized with bacterial lipopolysaccharides.Mol Cell Biochem1981https://conductscience.org/library/papers/7019666PubMed
6,986,610Codon catalog usage and the genome hypothesis.Nucleic Acids Res1980https://conductscience.org/library/papers/6986610PubMed
6,959,108Relationship between the total size of exons and introns in protein-coding genes of higher eukaryotes.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6959108PubMed
6,938,980Nucleotide sequence divergence and functional constraint in mRNA evolution.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6938980PubMed

1 to 10 of 107

See all 107 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data9

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
GENBANKJ00549GENBANK
GENBANKJ00550GENBANK
GENBANKJ00551GENBANK
GENBANKJ00557GENBANK
GENBANKJ00558GENBANK
GENBANKJ00559GENBANK
GENBANKJ00565GENBANK
GENBANKJ00566GENBANK
GENBANKX00268GENBANK

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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