Paper · 115000

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

Max EE and 2 others. Proc Natl Acad Sci U S A, 1979. Cited by 506 papers, by iCite.

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ConductScience Library. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Papers, record 115000. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/115000

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1979; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/115000/; PubMed
DOI: https://doi.org/10.1073/pnas.76.7.3450; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC383843/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 506; iCite
Relative citation ratio, by iCite: 9; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Max EE	E E
2	Seidman JG	J G
3	Leder P	P

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Genes, MHC Class II	Major topic
Immunoglobulin Constant Regions	Major topic
Immunoglobulin Light Chains	Major topic
Immunoglobulin kappa-Chains	Major topic
Immunoglobulins	Major topic
Recombination, Genetic	Major topic
Animals
Base Sequence
DNA
Genetic Variation
Immunoglobulin J-Chains
Mice
Multiple Myeloma
Neoplasms, Experimental
Nucleic Acid Conformation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	100,225	A complete immunoglobulin gene is created by somatic recombination.	Cell	1978	https://conductscience.org/library/papers/100225	PubMed
2	103,003	Rearrangement of genetic information may produce immunoglobulin diversity.	Nature	1978	https://conductscience.org/library/papers/103003	PubMed
3	103,004	The arrangement and rearrangement of antibody genes.	Nature	1978	https://conductscience.org/library/papers/103004	PubMed
4	103,573	k Chain variable regions from three galactan binding myeloma proteins.	Biochemistry	1978	https://conductscience.org/library/papers/103573	PubMed
5	103,630	Sequences of mouse immunoglobulin light chain genes before and after somatic changes.	Cell	1978	https://conductscience.org/library/papers/103630	PubMed
6	106,304	Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.	Nature	1979	https://conductscience.org/library/papers/106304	PubMed
7	106,394	Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.	Proc Natl Acad Sci U S A	1979	https://conductscience.org/library/papers/106394	PubMed
8	111,245	Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions.	Proc Natl Acad Sci U S A	1979	https://conductscience.org/library/papers/111245	PubMed
9	265,521	A new method for sequencing DNA.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/265521	PubMed
10	268,248	Model-building studies of antigen-binding sites: the hapten-binding site of mopc-315.	Cold Spring Harb Symp Quant Biol	1977	https://conductscience.org/library/papers/268248	PubMed

1 to 10 of 30

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Cited by205

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 506 citations.

PMID	Title	Journal	Year	In Papers	Source
39,708,804	Mutability and hypermutation antagonize immunoglobulin codon optimality.	Mol Cell	2025	https://conductscience.org/library/papers/39708804	PubMed
36,550,555	T-cell repertoire diversity: friend or foe for protective antitumor response?	J Exp Clin Cancer Res	2022	https://conductscience.org/library/papers/36550555	PubMed
32,878,258	Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions.	Biomedicines	2020	https://conductscience.org/library/papers/32878258	PubMed
30,476,719	Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination.	Curr Opin Struct Biol	2018	https://conductscience.org/library/papers/30476719	PubMed
27,404,392	Analyzing the CDR3 Repertoire with respect to TCR-Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS.	Sci Rep	2016	https://conductscience.org/library/papers/27404392	PubMed
26,018,782	Novel molecular mechanism for generating NK-cell fitness and memory.	Eur J Immunol	2015	https://conductscience.org/library/papers/26018782	PubMed
23,898,036	Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.	J Immunol	2013	https://conductscience.org/library/papers/23898036	PubMed
23,039,142	Role of recombination activating genes in the generation of antigen receptor diversity and beyond.	Immunology	2012	https://conductscience.org/library/papers/23039142	PubMed
22,287,713	Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.	J Immunol	2012	https://conductscience.org/library/papers/22287713	PubMed
20,728,025	The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.	Adv Immunol	2010	https://conductscience.org/library/papers/20728025	PubMed

1 to 10 of 205

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data6

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession	Source
GENBANK	J00549	GENBANK
GENBANK	J00551	GENBANK
GENBANK	J00557	GENBANK
GENBANK	J00558	GENBANK
GENBANK	J00559	GENBANK
GENBANK	X00268	GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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