Paper · 11274381

Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes.

Yu K and 1 other. Proc Natl Acad Sci U S A, 2001. Cited by 43 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes. Papers, record 11274381. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/11274381

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 2001; PubMed
Publication types: Comment, Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/11274381/; PubMed
DOI: https://doi.org/10.1073/pnas.081082498; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC33332/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 43; iCite
Relative citation ratio, by iCite: 0.79; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Yu K	K
2	Ornitz DM	D M

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acrocephalosyndactylia	Major topic
Receptor Protein-Tyrosine Kinases	Major topic
Receptors, Fibroblast Growth Factor	Major topic
Animals
Disease Models, Animal
Fibroblast Growth Factors
Humans
Ligands
Mice
Mutation
Phenotype
Receptor, Fibroblast Growth Factor, Type 2
Signal Transduction

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
HD30652	NICHD NIH HHS	United States		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment on	11,274,405	A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes.	https://conductscience.org/library/papers/11274405

Source PubMed

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	10,631,169	An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.	Development	2000	https://conductscience.org/library/papers/10631169	PubMed
2	7,719,344	Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome.	Nat Genet	1995	https://conductscience.org/library/papers/7719344	PubMed
3	7,583,099	Functions of fibroblast growth factors and their receptors.	Curr Biol	1995	https://conductscience.org/library/papers/7583099	PubMed
4	8,585,128	Fibroblast-growth-factor receptor mutations in human skeletal disorders.	Trends Genet	1995	https://conductscience.org/library/papers/8585128	PubMed
5	8,663,044	Receptor specificity of the fibroblast growth factor family.	J Biol Chem	1996	https://conductscience.org/library/papers/8663044	PubMed
6	8,755,573	Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras.	Proc Natl Acad Sci U S A	1996	https://conductscience.org/library/papers/8755573	PubMed
7	9,427,842	The heparan sulfate-fibroblast growth factor family: diversity of structure and function.	Prog Nucleic Acid Res Mol Biol	1998	https://conductscience.org/library/papers/9427842	PubMed
8	9,435,295	Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.	Development	1998	https://conductscience.org/library/papers/9435295	PubMed
9	9,560,232	Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development.	Proc Natl Acad Sci U S A	1998	https://conductscience.org/library/papers/9560232	PubMed
10	9,582,367	Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7).	J Biol Chem	1998	https://conductscience.org/library/papers/9582367	PubMed

1 to 10 of 33

See all 33 references

Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 43 citations.

PMID	Title	Journal	Year	In Papers	Source
36,806,206	Mendelian inheritance revisited: dominance and recessiveness in medical genetics.	Nat Rev Genet	2023	https://conductscience.org/library/papers/36806206	PubMed
34,007,277	2b or Not 2b: How Opposing FGF Receptor Splice Variants Are Blocking Progress in Precision Oncology.	J Oncol	2021	https://conductscience.org/library/papers/34007277	PubMed
30,234,486	Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis.	Elife	2018	https://conductscience.org/library/papers/30234486	PubMed
27,859,991	Signaling networks in joint development.	Dev Dyn	2017	https://conductscience.org/library/papers/27859991	PubMed
26,589,935	From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.	Curr Top Dev Biol	2015	https://conductscience.org/library/papers/26589935	PubMed
26,340,332	A Genetic-Pathophysiological Framework for Craniosynostosis.	Am J Hum Genet	2015	https://conductscience.org/library/papers/26340332	PubMed
26,220,993	Fibroblast growth factor signaling in skeletal development and disease.	Genes Dev	2015	https://conductscience.org/library/papers/26220993	PubMed
25,772,309	The Fibroblast Growth Factor signaling pathway.	Wiley Interdiscip Rev Dev Biol	2015	https://conductscience.org/library/papers/25772309	PubMed
24,489,893	A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation.	PLoS One	2014	https://conductscience.org/library/papers/24489893	PubMed
23,732,477	Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology.	Cold Spring Harb Perspect Biol	2013	https://conductscience.org/library/papers/23732477	PubMed

1 to 10 of 19

See all 19 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
FGFR2	2,263	PubTator's text mining	https://conductscience.org/library/genes/2263

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/11274381

GET https://conductscience.org/api/papers/v1/11274381/references?page=2

API reference For AI assistants