Paper · 9560232

Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development.

Arman E and 4 others. Proc Natl Acad Sci U S A, 1998. Cited by 494 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Papers, record 9560232. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9560232

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1998; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/9560232/; PubMed
DOI: https://doi.org/10.1073/pnas.95.9.5082; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC20217/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 494; iCite
Relative citation ratio, by iCite: 9.06; iCite
Revised in PubMed: 2023-03-31; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Arman E	E
2	Haffner-Krausz R	R
3	Chen Y	Y
4	Heath JK	J K
5	Lonai P	P

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Embryo Implantation	Major topic
Receptor Protein-Tyrosine Kinases	Major topic
Receptors, Fibroblast Growth Factor	Major topic
Animals
Cell Differentiation
Female
Gene Expression Regulation, Developmental
Genes, Lethal
Gestational Age
In Situ Hybridization
Mice
Mice, Knockout
Pregnancy
RNA, Messenger
Receptor, Fibroblast Growth Factor, Type 2

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	9,435,295	Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.	Development	1998	https://conductscience.org/library/papers/9435295	PubMed
2	6,302,028	Origin and differentiation of extraembryonic tissues in the mouse.	Int Rev Exp Pathol	1983	https://conductscience.org/library/papers/6302028	PubMed
3	1,309,608	Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.	Proc Natl Acad Sci U S A	1992	https://conductscience.org/library/papers/1309608	PubMed
4	7,923,352	FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations.	Cell	1994	https://conductscience.org/library/papers/7923352	PubMed
5	8,058,792	E-cadherin null mutant embryos fail to form a trophectoderm epithelium.	Proc Natl Acad Sci U S A	1994	https://conductscience.org/library/papers/8058792	PubMed
6	8,601,314	Fibroblast growth factor receptor 3 is a negative regulator of bone growth.	Cell	1996	https://conductscience.org/library/papers/8601314	PubMed
7	7,506,139	FGF-4 regulates expression of Evx-1 in the developing mouse limb.	Development	1993	https://conductscience.org/library/papers/7506139	PubMed
8	7,973,639	The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.	Science	1994	https://conductscience.org/library/papers/7973639	PubMed
9	7,583,099	Functions of fibroblast growth factors and their receptors.	Curr Biol	1995	https://conductscience.org/library/papers/7583099	PubMed
10	3,479,265	Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.	Cell	1987	https://conductscience.org/library/papers/3479265	PubMed

1 to 10 of 38

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Cited by216

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 494 citations.

PMID	Title	Journal	Year	In Papers	Source
42,072,609	The Critical Functions of FGF2, LIF and IGF1 in the Improvement of In Vitro Embryo Production.	Biomolecules	2026	https://conductscience.org/library/papers/42072609	PubMed
40,813,453	Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state.	Nat Cell Biol	2025	https://conductscience.org/library/papers/40813453	PubMed
40,085,503	Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone.	Elife	2025	https://conductscience.org/library/papers/40085503	PubMed
39,180,242	Propagating pluripotency - The conundrum of self-renewal.	Bioessays	2024	https://conductscience.org/library/papers/39180242	PubMed
38,739,352	Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models.	Curr Osteoporos Rep	2024	https://conductscience.org/library/papers/38739352	PubMed
38,531,359	Ancestry dynamics and trait selection in a designer cat breed.	Curr Biol	2024	https://conductscience.org/library/papers/38531359	PubMed
38,494,425	Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency.	Int J Stem Cells	2025	https://conductscience.org/library/papers/38494425	PubMed
38,113,263	Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice.	Proc Natl Acad Sci U S A	2023	https://conductscience.org/library/papers/38113263	PubMed
37,889,637	Developmental Hurdles That Can Compromise Pregnancy during the First Month of Gestation in Cattle.	Animals (Basel)	2023	https://conductscience.org/library/papers/37889637	PubMed
37,750,740	Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal Stromal Thinning.	Invest Ophthalmol Vis Sci	2023	https://conductscience.org/library/papers/37750740	PubMed

1 to 10 of 216

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
FGF4	2,249	PubTator's text mining	https://conductscience.org/library/genes/2249	NCBI Gene
FGFR2	2,263	PubTator's text mining	https://conductscience.org/library/genes/2263	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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