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Paper137248

Increased insulin binding by hepatic plasma membranes from diabetic rats: normalization by insulin therapy.

Davidson MB and 1 other. J Clin Invest, 1977. Cited by 183 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Increased insulin binding by hepatic plasma membranes from diabetic rats: normalization by insulin therapy. Papers, record 137248. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/137248

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Increased insulin binding by hepatic plasma membranes from diabetic rats: normalization by insulin therapy.
PubMed
Journal
J Clin Invest
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
183
iCite
Relative citation ratio, by iCite
6.03
iCite
Revised in PubMed
2018-11-13
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Davidson MBM B
2Kaplan SAS A

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Diabetes MellitusMajor topic
LiverMajor topic
Receptor, InsulinMajor topic
Animals
Cell Membrane
Insulin
Rats
Streptozocin

Source PubMed

References43

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,354,452Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance.Biochem Biophys Res Commun1973https://conductscience.org/library/papers/4354452PubMed
24,359,334Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4359334PubMed
3173,609The control of insulin receptors in the New Zealand obese mouse.Diabetologia1975https://conductscience.org/library/papers/173609PubMed
44,474,186Decreased insulin binding to lymphocytes from diabetic subjects.J Clin Invest1974https://conductscience.org/library/papers/4474186PubMed
54,348,209Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance.J Biol Chem1973https://conductscience.org/library/papers/4348209PubMed
61,117,842The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes.Metabolism1975https://conductscience.org/library/papers/1117842PubMed
72,834Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats.Metabolism1976https://conductscience.org/library/papers/2834PubMed
85,648,365Studies of the metabolism of isolated livers of normal and alloxan-diabetic rats perfused with insulin.Diabetes1968https://conductscience.org/library/papers/5648365PubMed
9171,257Insulin-induced reduction of membrane receptor concentrations in isolated fat cells and lymphocytes. Independence from receptor occupation and possible relation to proteolytic activity of insulin.J Biol Chem1975https://conductscience.org/library/papers/171257PubMed
104,260,623Insulin receptor of fat cells in insulin-resistant metabolic states.Science1972https://conductscience.org/library/papers/4260623PubMed
114,748,361Binding and degradation of 125I-labelled insulin by isolated rat fat cells.Biochim Biophys Acta1973https://conductscience.org/library/papers/4748361PubMed
125,033,396Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation.J Biol Chem1972https://conductscience.org/library/papers/5033396PubMed
13177,453Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.J Clin Invest1976https://conductscience.org/library/papers/177453PubMed
14169,296Insulin receptor deficiency in genetic and acquired obesity.J Clin Invest1975https://conductscience.org/library/papers/169296PubMed
155,288,373Insulin--receptor interactions in adipose tissue cells: direct measurement and properties.Proc Natl Acad Sci U S A1971https://conductscience.org/library/papers/5288373PubMed
164,967,807Isolation of an organ specific protein antigen from cell-surface membrane of rat liver.Biochim Biophys Acta1968https://conductscience.org/library/papers/4967807PubMed
1714,201,146STUDIES ON PLASMA MEMBRANES. I. CHEMICAL COMPOSITION AND ENZYME CONTENT OF PLASMA MEMBRANES ISOLATED FROM RAT LIVER.Biochim Biophys Acta1964https://conductscience.org/library/papers/14201146PubMed
18163,493Prolactin receptors in rat liver: possible induction by prolactin.Science1975https://conductscience.org/library/papers/163493PubMed
195,409,930Effect of fasting on insulin secretion and action in mice.Endocrinology1970https://conductscience.org/library/papers/5409930PubMed
204,686,369Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man.J Clin Endocrinol Metab1973https://conductscience.org/library/papers/4686369PubMed

See all 43 references

Cited by29

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 183 citations.

PMIDTitleJournalYearIn PapersSource
30,894,246Effect of Age on Diabetogenicity of Alloxan in Ossabaw Miniature Swine.Comp Med2019https://conductscience.org/library/papers/30894246PubMed
18,638,371
Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats.
BMC Mol Biol2008https://conductscience.org/library/papers/18638371PubMed
9,419,000Colocalisation of insulin and IGF-1 receptors in cultured rat sensory and sympathetic ganglion cells.J Anat1997https://conductscience.org/library/papers/9419000PubMed
8,509,304Immunocytochemical localisation of insulin receptors on rat superior cervical ganglion neurons in dissociated cell culture.J Anat1993https://conductscience.org/library/papers/8509304PubMed
7,044,376Insulin binding to liver plasma membranes from rats rendered diabetic by alloxan. A kinetic demonstration of two classes of binding sites in equilibrium with each other.Biochem J1982https://conductscience.org/library/papers/7044376PubMed
7,008,780Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats.Biochem J1980https://conductscience.org/library/papers/7008780PubMed
7,000,600Insulin binding and insulin action in rat fat cells after adrenalectomy.Diabetologia1980https://conductscience.org/library/papers/7000600PubMed
6,759,277Insulin binding and action in antibody-induced diabetes in the rat.Diabetologia1982https://conductscience.org/library/papers/6759277PubMed
6,451,633Increased clearance and degradation of [3H]insulin in streptozotocin diabetic rats.J Clin Invest1981https://conductscience.org/library/papers/6451633PubMed
6,354,812Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice.Diabetologia1983https://conductscience.org/library/papers/6354812PubMed
6,348,255Effects of streptozotocin diabetes and fasting on intracellular sodium and adenosine triphosphate in rat soleus muscle.J Physiol1983https://conductscience.org/library/papers/6348255PubMed
6,338,044Insulin resistance in uremia. Characterization of insulin action, binding, and processing in isolated hepatocytes from chronic uremic rats.J Clin Invest1983https://conductscience.org/library/papers/6338044PubMed
6,248,409The effect of streptozotocin-induced diabetes on the early steps of glucagon action in isolated rat liver cells.Diabetologia1980https://conductscience.org/library/papers/6248409PubMed
3,892,914Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status.West J Med1985https://conductscience.org/library/papers/3892914PubMed
3,517,068Studies of the human liver insulin receptor in noninsulin-dependent diabetes mellitus.J Clin Invest1986https://conductscience.org/library/papers/3517068PubMed
3,328,718Enhanced hepatic insulin sensitivity, but peripheral insulin resistance in patients with type 1 (insulin-dependent) diabetes.Diabetologia1987https://conductscience.org/library/papers/3328718PubMed
3,305,682Insulin receptors on circulating blood cells from patients with pancreatogenic diabetes: a comparison with type I diabetes and normal subjects.J Endocrinol Invest1987https://conductscience.org/library/papers/3305682PubMed
3,154,820Morphological change in pancreatic islets, insulin binding and intracellular glucose metabolism in adipocytes of streptozotocin-induced diabetic rats.Korean J Intern Med1987https://conductscience.org/library/papers/3154820PubMed
2,498,395
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.
J Clin Invest1989https://conductscience.org/library/papers/2498395PubMed
1,866,369Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated diabetic rats.Pharm Res1991https://conductscience.org/library/papers/1866369PubMed

See all 29 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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