Paper · 16645170

Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin.

Chang KH and 6 others. Blood, 2006. Cited by 100 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin. Papers, record 16645170. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16645170

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin.; PubMed
Journal: Blood; PubMed
Year: 2006; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/16645170/; PubMed
DOI: https://doi.org/10.1182/blood-2005-11-011874; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1895504/; PubMed
The journal: https://conductscience.org/library/journal-index/7603509; PubMed
Citations, by iCite: 100; iCite
Relative citation ratio, by iCite: 1.79; iCite
Revised in PubMed: 2021-10-20; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Chang KH	Kai-Hsin
2	Nelson AM	Angelique M
3	Cao H	Hua
4	Wang L	Linlin
5	Nakamoto B	Betty
6	Ware CB	Carol B
7	Papayannopoulou T	Thalia

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Erythrocytes	Major topic
Fetal Hemoglobin	Major topic
Hematopoiesis	Major topic
Stem Cells	Major topic
Cell Differentiation
DNA Primers
Embryo, Mammalian
Gene Expression Regulation
Globins
Humans
Kinetics
Polymerase Chain Reaction
RNA, Messenger
fms-Like Tyrosine Kinase 3

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
1P20GM69983	NIGMS NIH HHS	United States	P20GM069983	PubMed and NIH	NIH RePORTER
DK055820	NIDDK NIH HHS	United States	P01DK055820	PubMed and NIH	NIH RePORTER
T32-HL007093	NHLBI NIH HHS	United States	T32HL007093	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,183,666	Hemoglobin switching in culture: evidence for a humoral factor that induces switching in adult and neonatal but not fetal erythroid cells.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6183666	PubMed
2	9,632,803	Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion.	Mol Cell Biol	1998	https://conductscience.org/library/papers/9632803	PubMed
3	8,417,345	Hematopoietic commitment during embryonic stem cell differentiation in culture.	Mol Cell Biol	1993	https://conductscience.org/library/papers/8417345	PubMed
4	15,831,705	Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development.	Blood	2005	https://conductscience.org/library/papers/15831705	PubMed
5	11,535,826	Hematopoietic colony-forming cells derived from human embryonic stem cells.	Proc Natl Acad Sci U S A	2001	https://conductscience.org/library/papers/11535826	PubMed
6	16,018,548	Controlled-rate freezing of human ES cells.	Biotechniques	2005	https://conductscience.org/library/papers/16018548	PubMed
7	15,914,555	Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation.	Blood	2005	https://conductscience.org/library/papers/15914555	PubMed
8	14,962,900	CD34+CD38- hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern.	Blood	2004	https://conductscience.org/library/papers/14962900	PubMed
9	6,198,658	Studies of hemoglobin expression in erythroid cells of early human fetuses using anti-gamma- and anti-beta-globin chain fluorescent antibodies.	Prog Clin Biol Res	1983	https://conductscience.org/library/papers/6198658	PubMed
10	6,202,344	Monoclonal antibodies detecting antigenic determinants with restricted expression on erythroid cells: from the erythroid committed progenitor level to the mature erythroblast.	Blood	1984	https://conductscience.org/library/papers/6202344	PubMed

1 to 10 of 24

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Cited by60

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 100 citations.

PMID	Title	Journal	Year	In Papers	Source
39,309,892	Enhancing terminal erythroid differentiation in human embryonic stem cells through TRIB3 overexpression.	Heliyon	2024	https://conductscience.org/library/papers/39309892	PubMed
37,626,061	Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium.	NPJ Regen Med	2023	https://conductscience.org/library/papers/37626061	PubMed
37,296,674	Generation of Red Blood Cells from Human Pluripotent Stem Cells-An Update.	Cells	2023	https://conductscience.org/library/papers/37296674	PubMed
35,741,044	Challenges in Cell Fate Acquisition to Scid-Repopulating Activity from Hemogenic Endothelium of hiPSCs Derived from AML Patients Using Forced Transcription Factor Expression.	Cells	2022	https://conductscience.org/library/papers/35741044	PubMed
35,249,258	Analyses of erythropoiesis from embryonic stem cell-CD34+ and cord blood-CD34+ cells reveal mechanisms for defective expansion and enucleation of embryomic stem cell-erythroid cells.	J Cell Mol Med	2022	https://conductscience.org/library/papers/35249258	PubMed
34,575,977	Industrially Compatible Transfusable iPSC-Derived RBCs: Progress, Challenges and Prospective Solutions.	Int J Mol Sci	2021	https://conductscience.org/library/papers/34575977	PubMed
33,843,988	Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors.	Blood Adv	2021	https://conductscience.org/library/papers/33843988	PubMed
32,830,529	In Vitro Generation of Red Blood Cells from Stem Cell and Targeted Therapy.	Cell Transplant	2020	https://conductscience.org/library/papers/32830529	PubMed
30,671,230	Research advances in erythrocyte regeneration sources and methods in vitro.	Cell Regen	2018	https://conductscience.org/library/papers/30671230	PubMed
28,213,976	Enhancement of β-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA.	Stem Cells Transl Med	2017	https://conductscience.org/library/papers/28213976	PubMed

1 to 10 of 60

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
FLT3LG	2,323	PubTator's text mining	https://conductscience.org/library/genes/2323	NCBI Gene
PTPRC	5,788	PubTator's text mining	https://conductscience.org/library/genes/5788	NCBI Gene
VEGFA	7,422	PubTator's text mining	https://conductscience.org/library/genes/7422	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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