Paper · 15831705
Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development.
Zambidis ET and 4 others. Blood, 2005. Cited by 273 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Papers, record 15831705. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/15831705
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development.
- PubMed
- Publication types
- Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
- PubMed
Topics16
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Endothelium | Major topic |
| Hematopoiesis | Major topic |
| Stem Cells | Major topic |
| Antigens, CD | |
| Cell Differentiation | |
| Cell Lineage | |
| Cells, Cultured | |
| Embryo, Mammalian | |
| Erythropoiesis | |
| Gene Expression Profiling | |
| Gene Expression Regulation, Developmental | |
| Humans | |
| Leukocyte Common Antigens | |
| Myelopoiesis | |
| Transcription Factors | |
| Yolk Sac |
Source PubMed
Grants4
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| K08 HL077595 | NHLBI NIH HHS | United States | K08HL077595 | PubMed and NIH | NIH RePORTER |
| K08-HL077595 | NHLBI NIH HHS | United States | K08HL077595 | PubMed and NIH | NIH RePORTER |
| T32 CA60441 | NCI NIH HHS | United States | T32CA060441 | PubMed and NIH | NIH RePORTER |
| R21-HL077729 | NHLBI NIH HHS | United States | R21HL077729 | PubMed | NIH RePORTER |
Trials1
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
| Trial | Title | The trial lists it as | Named in the paper's record |
|---|---|---|---|
| NCT07607392 | JAK2V617F Mutated Endothelium Has a Stem Cell Potential in Primary Myelofibrosis: a New Disease Ontogenesis for Chronic Myeloproliferative Disorders | Background |
Source ClinicalTrials.gov
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References70
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 3,722,384 | Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition. | J Clin Invest | 1986 | https://conductscience.org/library/papers/3722384 | PubMed |
| 2 | 21,437,810 | Hematopoietic Development of ES Cells in Culture. | Methods Mol Med | 2002 | https://conductscience.org/library/papers/21437810 | PubMed |
| 3 | 8,614,833 | In vitro development of primitive and definitive erythrocytes from different precursors. | Science | 1996 | https://conductscience.org/library/papers/8614833 | PubMed |
| 4 | 1,591,994 | Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development. | Development | 1992 | https://conductscience.org/library/papers/1591994 | PubMed |
| 5 | 10,051,611 | In vitro hematopoietic and endothelial potential of flk-1(-/-) embryonic stem cells and embryos. | Proc Natl Acad Sci U S A | 1999 | https://conductscience.org/library/papers/10051611 | PubMed |
| 6 | 10,748,519 | Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. | Nat Biotechnol | 2000 | https://conductscience.org/library/papers/10748519 | PubMed |
| 7 | 10,529,424 | Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. | Development | 1999 | https://conductscience.org/library/papers/10529424 | PubMed |
| 8 | 11,955,444 | HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. | Cell | 2002 | https://conductscience.org/library/papers/11955444 | PubMed |
| 9 | 9,655,490 | In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. | Immunity | 1998 | https://conductscience.org/library/papers/9655490 | PubMed |
| 10 | 8,639,768 | Early ontogeny of the human marrow from long bones: an immunohistochemical study of hematopoiesis and its microenvironment. | Blood | 1996 | https://conductscience.org/library/papers/8639768 | PubMed |
1 to 10 of 70
See all 70 referencesCited by147
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 273 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,528,516 | Modeling myeloid cell development in health and disease using induced pluripotent stem cells. | Front Immunol | 2026 | https://conductscience.org/library/papers/42528516 | PubMed |
| 42,453,360 | Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges. | Curr Stem Cell Rep | 2018 | https://conductscience.org/library/papers/42453360 | PubMed |
| 41,512,861 | Generation of thymus-reconstituting T cell progenitors from human pluripotent stem cells. | Cell Rep Methods | 2026 | https://conductscience.org/library/papers/41512861 | PubMed |
| 41,483,809 | Hematopoietic organoids: Opportunities and challenges in modeling human hematopoiesis and diseases in vitro. | Stem Cell Reports | 2026 | https://conductscience.org/library/papers/41483809 | PubMed |
| 39,875,377 | Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells. | Cell Discov | 2025 | https://conductscience.org/library/papers/39875377 | PubMed |
| 39,676,663 | The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni. | Nucleic Acids Res | 2025 | https://conductscience.org/library/papers/39676663 | PubMed |
| 38,290,102 | Modeling primitive and definitive erythropoiesis with induced pluripotent stem cells. | Blood Adv | 2024 | https://conductscience.org/library/papers/38290102 | PubMed |
| 37,936,199 | Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins. | Stem Cell Res Ther | 2023 | https://conductscience.org/library/papers/37936199 | PubMed |
| 37,928,777 | Engineering T Cell Development for the Next Generation of Stem Cell-Derived Immunotherapies. | GEN Biotechnol | 2023 | https://conductscience.org/library/papers/37928777 | PubMed |
| 37,461,708 | Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins. | Res Sq | 2023 | https://conductscience.org/library/papers/37461708 | PubMed |
1 to 10 of 147
See all 147 cited byGenes11
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| ANPEP | 290 | PubTator's text mining | https://conductscience.org/library/genes/290 | NCBI Gene |
| CD34 | 947 | PubTator's text mining | https://conductscience.org/library/genes/947 | NCBI Gene |
| CDX4 | 1,046 | PubTator's text mining | https://conductscience.org/library/genes/1046 | NCBI Gene |
| GATA1 | 2,623 | PubTator's text mining | https://conductscience.org/library/genes/2623 | NCBI Gene |
| GATA2 | 2,624 | PubTator's text mining | https://conductscience.org/library/genes/2624 | NCBI Gene |
| GYPA | 2,993 | PubTator's text mining | https://conductscience.org/library/genes/2993 | NCBI Gene |
| PECAM1 | 5,175 | PubTator's text mining | https://conductscience.org/library/genes/5175 | NCBI Gene |
| PTPRC | 5,788 | PubTator's text mining | https://conductscience.org/library/genes/5788 | NCBI Gene |
| TAL1 | 6,886 | PubTator's text mining | https://conductscience.org/library/genes/6886 | NCBI Gene |
| TCF12 | 6,938 | PubTator's text mining | https://conductscience.org/library/genes/6938 | NCBI Gene |
1 to 10 of 11
See all 11 genesDrugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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