Paper · 17554339
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
Li X and 3 others. Nature, 2007. Cited by 404 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Papers, record 17554339. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17554339
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
- PubMed
Topics15
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Gene Expression Regulation | Major topic |
| Liver | Major topic |
| Proto-Oncogene Proteins c-akt | Major topic |
| Trans-Activators | Major topic |
| Animals | |
| Cell Line, Tumor | |
| Chromatin | |
| Diabetes Mellitus, Type 2 | |
| Down-Regulation | |
| Glucose | |
| Mice | |
| Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | |
| Phosphorylation | |
| Phosphoserine | |
| Transcription Factors |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References0
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
None in this release.
Cited by270
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 404 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,908,178 | Estradiol-PGC-1 signaling in mitochondrial health: Implications for perimenopause and cardiovascular disease. | Physiol Rep | 2026 | https://conductscience.org/library/papers/42908178 | PubMed |
| 42,319,436 | Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation. | J Mol Med (Berl) | 2026 | https://conductscience.org/library/papers/42319436 | PubMed |
| 42,288,900 | Post-translational modifications of mitochondrion-related proteins: integrative orchestrators of cell fate networks in cardiovascular disease. | Cell Commun Signal | 2026 | https://conductscience.org/library/papers/42288900 | PubMed |
| 42,178,519 | Activation of the RAS/PPARα pathway reduces backfat deposition of Gayal (Bos frontalis). | BMC Genomics | 2026 | https://conductscience.org/library/papers/42178519 | PubMed |
| 41,913,210 | Metabolic reprogramming of CAR-T cells: a multi-pronged strategy to conquer the immunosuppressive tumor microenvironment. | Cell Commun Signal | 2026 | https://conductscience.org/library/papers/41913210 | PubMed |
| 41,462,634 | HDGF Protects Retinal Pigment Epithelium from Glyoxal-Induced Ferroptosis via SIRT1/PGC-1α/Nrf2 Pathway. | Antioxidants (Basel) | 2025 | https://conductscience.org/library/papers/41462634 | PubMed |
| 41,460,266 | Study on the expression changes of hepatic Gluconeogenesis-related proteins induced by insulin Overdose-related liver injury. | Forensic Toxicol | 2026 | https://conductscience.org/library/papers/41460266 | PubMed |
| 41,456,074 | PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues. | Cell Biosci | 2025 | https://conductscience.org/library/papers/41456074 | PubMed |
| 41,321,489 | Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice. | Front Physiol | 2025 | https://conductscience.org/library/papers/41321489 | PubMed |
| 41,220,146 | Nuclear Receptor Subfamily 4 Group A Member 1 Exacerbates Cardiac Remodeling by Inhibiting Mitochondrial Function Through the Peroxisome Proliferator-Activated Receptor γ Coactivator-1α/Nuclear Respiratory Factor 1/Transcription Factor A Mitochondrial Axis. | J Am Heart Assoc | 2025 | https://conductscience.org/library/papers/41220146 | PubMed |
1 to 10 of 270
See all 270 cited byGenes6
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| AKT1 | 207 | PubTator's text mining | https://conductscience.org/library/genes/207 | NCBI Gene |
| AKT2 | 208 | PubTator's text mining | https://conductscience.org/library/genes/208 | NCBI Gene |
| INS | 3,630 | PubTator's text mining | https://conductscience.org/library/genes/3630 | NCBI Gene |
| PPARGC1A | 10,891 | PubTator's text mining | https://conductscience.org/library/genes/10891 | NCBI Gene |
| PPARGC1B | 133,522 | PubTator's text mining | https://conductscience.org/library/genes/133522 | NCBI Gene |
| WASF1 | 8,936 | PubTator's text mining | https://conductscience.org/library/genes/8936 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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