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Paper · 19252480

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.

Park BS and 5 others. Nature, 2009. Cited by 1,932 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Papers, record 19252480. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19252480

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.
PubMed
Journal
Nature
PubMed
Year
2009
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,932
iCite
Relative citation ratio, by iCite
47.7
iCite
Revised in PubMed
2024-01-09
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Park BSBeom Seok
2Song DHDong Hyun
3Kim HMHo Min
4Choi BSByong-Seok
5Lee HHayyoung
6Lee JOJie-Oh

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
LipopolysaccharidesMajor topic
Lymphocyte Antigen 96Major topic
Toll-Like Receptor 4Major topic
Binding Sites
Crystallography, X-Ray
Escherichia coli
Humans
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Protein Binding
Protein Multimerization
Structure-Activity Relationship

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
117,803,912Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.Cell2007https://conductscience.org/library/papers/17803912PubMed
215,961,631Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.Science2005https://conductscience.org/library/papers/15961631PubMed
312,557,186Structure validation by Calpha geometry: phi,psi and Cbeta deviation.Proteins2003https://conductscience.org/library/papers/12557186PubMed
416,953,972Roles for accessory molecules in microbial recognition by Toll-like receptors.J Endotoxin Res2006https://conductscience.org/library/papers/16953972PubMed
58,119,492Bacterial endotoxin: molecular relationships of structure to activity and function.FASEB J1994https://conductscience.org/library/papers/8119492PubMed
62,579,812Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities.Eur J Biochem1985https://conductscience.org/library/papers/2579812PubMed
716,670,331Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.J Immunol2006https://conductscience.org/library/papers/16670331PubMed
818,701,082Structures of the toll-like receptor family and its ligand complexes.Immunity2008https://conductscience.org/library/papers/18701082PubMed
917,517,123Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.BMC Genomics2007https://conductscience.org/library/papers/17517123PubMed
1012,563,300Innate immune sensing and its roots: the story of endotoxin.Nat Rev Immunol2003https://conductscience.org/library/papers/12563300PubMed

1 to 10 of 33

See all 33 references

Cited by1,246

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,932 citations.

PMIDTitleJournalYearIn PapersSource
42,949,064Bacterial Surfaces and Barriers: Biogenesis and Pathogen-Host Interactions.Chem Rev2026https://conductscience.org/library/papers/42949064PubMed
42,943,278Old Drugs, New Targets: Molecular Docking Insights into Repurposing Proton Pump Inhibitors for the TLR4/MD-2, NLRP3, and C5aR1 Axes in Autoimmune Liver Diseases.Pharmaceuticals (Basel)2026https://conductscience.org/library/papers/42943278PubMed
42,940,363Mechanisms of Carrageenan-Induced Immune Inflammation and Thrombosis: A Narrative Review.Foods2026https://conductscience.org/library/papers/42940363PubMed
42,939,260Investigating the Pharmacological Basis of Xiaochaihu-Tang in Diabetic Cognitive Impairment: A Network Pharmacology Approach.Brain Sci2026https://conductscience.org/library/papers/42939260PubMed
42,936,671Nanovaccination Against Pseudomonas aeruginosa: Immune Mechanisms, Antigen Design Strategies, and Nanocarrier Platforms.Int J Nanomedicine2026https://conductscience.org/library/papers/42936671PubMed
42,904,171Mechanism of action of a bactericidal lipopeptide which targets lipopolysaccharides of the plant pathogen Xylella fastidiosa.Front Plant Sci2026https://conductscience.org/library/papers/42904171PubMed
42,903,459In Silico Design and Immunogenicity Evaluation of a Multiepitope Vaccine Candidate Against Leishmania tropica in BALB/c Mice.J Parasitol Res2026https://conductscience.org/library/papers/42903459PubMed
42,894,883Tissue-specific inflammatory responses to systemic LPS in mice with LysM-lineage Hmgb1 deletion.Brain Behav Immun Health2026https://conductscience.org/library/papers/42894883PubMed
42,885,563Pathogenicity and virulence of Neisseria gonorrhoeae.Virulence2026https://conductscience.org/library/papers/42885563PubMed
42,884,090Special Issue "The Role of Toll-like Receptors (TLRs) in Infection and Inflammation: Third Edition".Int J Mol Sci2026https://conductscience.org/library/papers/42884090PubMed

1 to 10 of 1,246

See all 1,246 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
TLR47,099Swiss-Prot's referenceshttps://conductscience.org/library/genes/7099NCBI Gene
LY9623,643PubTator's text mininghttps://conductscience.org/library/genes/23643NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
PDB3FXI

Source PDB

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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