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Paper19499

Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin-precipitable fraction of plasma.

Stathakis NE and 1 other. J Clin Invest, 1977. Cited by 350 papers, by iCite.

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ConductScience Library. Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin-precipitable fraction of plasma. Papers, record 19499. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19499

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin-precipitable fraction of plasma.
PubMed
Journal
J Clin Invest
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
350
iCite
Relative citation ratio, by iCite
10.6
iCite
Revised in PubMed
2018-11-13
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stathakis NEN E
2Mosesson MWM W

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CryoglobulinsMajor topic
FibrinogenMajor topic
HeparinMajor topic
Calcium
Chromatography, Affinity
Dose-Response Relationship, Drug
Humans
Hydrogen-Ion Concentration
Osmolar Concentration
Protein Binding

Source PubMed

References50

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,006,623Cryofibrinogen in the plasma of patients with skin ulcerative lesions on the legs: a complex of fibrinogen and cold insoluble globulin.Thromb Res1976https://conductscience.org/library/papers/1006623PubMed
21,006,626Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin iii and by gel filtration.Thromb Res1976https://conductscience.org/library/papers/1006626PubMed
31,091,021Heparin assay methods for control of in vivo heparin effects.Thromb Diath Haemorrh1975https://conductscience.org/library/papers/1091021PubMed
41,113,066Interaction of soluble fibroblast surface antigen with fribrinogen and fibrin.J Exp Med1975https://conductscience.org/library/papers/1113066PubMed
51,115,795Action of heparin on thrombin-antithrombin reaction.Biochim Biophys Acta1975https://conductscience.org/library/papers/1115795PubMed
61,138,882The cold-insoluble globulin of human plasma: studies of its essential structural features.Biochim Biophys Acta1975https://conductscience.org/library/papers/1138882PubMed
71,158,872Cross-linking of cold-insoluble globulin by fibrin-stabilizing factor.J Biol Chem1975https://conductscience.org/library/papers/1158872PubMed
812,017Interaction between proteins and glycosaminoglycans.Fed Proc1977https://conductscience.org/library/papers/12017PubMed
91,251,339Heparin precipitable fraction (HPF) from dermatoligical patients. I. Characterization of the thrombin-clottable protein.Thromb Res1976https://conductscience.org/library/papers/1251339PubMed
101,267,803The separation of active and inactive forms of heparin.Biochem Biophys Res Commun1976https://conductscience.org/library/papers/1267803PubMed
111,278,445Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.FEBS Lett1976https://conductscience.org/library/papers/1278445PubMed
1513,759,522Studies on fractionated heparin.Arch Biochem Biophys1961https://conductscience.org/library/papers/13759522PubMed
1613,850,331Precipitation of human fibrinogen with heparin.Scalpel (Brux)1960https://conductscience.org/library/papers/13850331PubMed
1713,899,386Binding of heparin to fibrin(ogen).Scand J Clin Lab Invest1961https://conductscience.org/library/papers/13899386PubMed
1813,953,457Cryofibrinogen: formation and inhibition in heparinized plasma.Am J Physiol1963https://conductscience.org/library/papers/13953457PubMed
1914,080,867SUBFRACTIONS OF HUMAN FIBRINOGEN; PREPARATION AND ANALYSIS.J Lab Clin Med1963https://conductscience.org/library/papers/14080867PubMed
20142,519Heterogeneity of the cold-insoluble globulin of human plasma (CIg), a circulating cell surface protein.Biochim Biophys Acta1977https://conductscience.org/library/papers/142519PubMed
22240,469Electrofocusing of heparin: fractionation of heparin into 21 components distinguishable from other acidic mucopolysaccharides.Biopolymers1975https://conductscience.org/library/papers/240469PubMed
234,097,343The cold-insoluble globulin of human plasma. I. Purification, primary characterization, and relationship to fibrinogen and other cold-insoluble fraction components.J Biol Chem1970https://conductscience.org/library/papers/4097343PubMed
244,114,358Electroimmuno assay.Scand J Clin Lab Invest Suppl1972https://conductscience.org/library/papers/4114358PubMed

See all 50 references

Cited by60

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 350 citations.

PMIDTitleJournalYearIn PapersSource
40,804,897Cryoproteins in Non-HCV-Related Autoimmune Disorders: A Serious Cold-Induced Problem.Diagnostics (Basel)2025https://conductscience.org/library/papers/40804897PubMed
39,020,021The emerging role of fibrin(ogen) in cardiovascular disease.Inflamm Res2024https://conductscience.org/library/papers/39020021PubMed
37,072,111Cryofibrinogen-Characteristics and Association with Cryoglobulin: A Retrospective Study Out of a Series of 1,712 Samples over 7 Years.Thromb Haemost2023https://conductscience.org/library/papers/37072111PubMed
27,098,513Fibronectin maintains the balance between hemostasis and thrombosis.Cell Mol Life Sci2016https://conductscience.org/library/papers/27098513PubMed
22,447,929Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120-kDa region of fibronectin to facilitate cell binding by Yersinia pestis.J Biol Chem2012https://conductscience.org/library/papers/22447929PubMed
20,498,264Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery.Infect Immun2010https://conductscience.org/library/papers/20498264PubMed
17,425,334Interaction of the fibronectin COOH-terminal Fib-2 regions with fibrin: further characterization and localization of the Fib-2-binding sites.Biochemistry2007https://conductscience.org/library/papers/17425334PubMed
9,310,245Cellular fibronectin concentration in the plasma of patients with malignant and benign diseases: a comparison with CA 19-9 and CEA.Br J Cancer1997https://conductscience.org/library/papers/9310245PubMed
8,760,376Structural domains of heparan sulphate for specific recognition of the C-terminal heparin-binding domain of human plasma fibronectin (HEPII).Biochem J1996https://conductscience.org/library/papers/8760376PubMed
7,340,825Binding of the basement-membrane glycoprotein laminin to glycosaminoglycans. An affinity-chromatography study.Biochem J1981https://conductscience.org/library/papers/7340825PubMed
7,254,200Phagocytosis-promoting activity of avian plasma and fibroblastic cell surface fibronectins.Mol Cell Biochem1981https://conductscience.org/library/papers/7254200PubMed
7,251,892Plasma fibronectin in normal subjects and in various disease states.J Clin Pathol1981https://conductscience.org/library/papers/7251892PubMed
7,251,676Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin.J Cell Biol1981https://conductscience.org/library/papers/7251676PubMed
7,204,498Concomitant loss of cell surface fibronectin and laminin from transformed rat kidney cells.J Cell Biol1981https://conductscience.org/library/papers/7204498PubMed
7,193,214Isolation and characterization of Chinese hamster ovary cell variants defective in adhesion to fibronectin-coated collagen.J Cell Biol1980https://conductscience.org/library/papers/7193214PubMed
7,096,593Fibronectin in exudative pleural effusions.J Clin Pathol1982https://conductscience.org/library/papers/7096593PubMed
7,047,404The adherence of group A streptococci to oropharyngeal cells: the lipoteichoic acid adhesin and fibronectin receptor.Infection1982https://conductscience.org/library/papers/7047404PubMed
7,030,313Isolation of an actin-binding fragment of fibronectin.Biochem J1981https://conductscience.org/library/papers/7030313PubMed
7,012,158Role of collagenous matrices in the adhesion and growth of cells.J Cell Biol1981https://conductscience.org/library/papers/7012158PubMed
7,002,956Distribution of fibronectin in normal and diseased human kidneys.J Clin Pathol1980https://conductscience.org/library/papers/7002956PubMed

See all 60 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
FGB2,244PubTator's text mininghttps://conductscience.org/library/genes/2244NCBI Gene
FN12,335PubTator's text mininghttps://conductscience.org/library/genes/2335NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Data

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  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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