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Paper · 19688034

Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.

Calebiro D and 7 others. PLoS Biol, 2009. Cited by 487 papers, by iCite.

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ConductScience Library. Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. Papers, record 19688034. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19688034

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.
PubMed
Journal
PLoS Biol
PubMed
Year
2009
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
487
iCite
Relative citation ratio, by iCite
11.3
iCite
Revised in PubMed
2021-10-20
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Calebiro DDavide
2Nikolaev VOViacheslav O
3Gagliani MCMaria Cristina
4de Filippis TTiziana
5Dees CChristian
6Tacchetti CCarlo
7Persani LLuca
8Lohse MJMartin J

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cyclic AMPMajor topic
GTP-Binding Protein alpha SubunitsMajor topic
Signal TransductionMajor topic
Subcellular FractionsMajor topic
Thyroid GlandMajor topic
ThyrotropinMajor topic
Adenylyl Cyclases
Animals
Cell Line
Cells, Cultured
Epithelial Cells
Fluorescent Dyes
Humans
Mice
Mice, Transgenic
Microscopy, Confocal
Models, Biological
Organic Chemicals
Receptors, Thyrotropin

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References92

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,617,619The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cells.J Biol Chem2000https://conductscience.org/library/papers/10617619PubMed
29,837,973Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein.J Biol Chem1998https://conductscience.org/library/papers/9837973PubMed
39,634,598Adenylyl cyclase co-distribution with the CaBPs, calbindin-D28 and calretinin, varies with cell type: assessment with the fluorescent dye, BODIPY forskolin, in enteric ganglia.Cell Tissue Res1998https://conductscience.org/library/papers/9634598PubMed
411,264,536Receptor-mediated activation of heterotrimeric G-proteins in living cells.Science2001https://conductscience.org/library/papers/11264536PubMed
57,983,176Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy.J Cell Sci1994https://conductscience.org/library/papers/7983176PubMed
615,961,389G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes.J Biol Chem2005https://conductscience.org/library/papers/15961389PubMed
716,357,307Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.Circ Res2006https://conductscience.org/library/papers/16357307PubMed
816,513,835The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.Endocrinology2006https://conductscience.org/library/papers/16513835PubMed
98,552,625cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.Proc Natl Acad Sci U S A1996https://conductscience.org/library/papers/8552625PubMed
1018,765,283One-step isolation of plasma membrane proteins using magnetic beads with immobilized concanavalin A.Protein Expr Purif2008https://conductscience.org/library/papers/18765283PubMed

1 to 10 of 92

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Cited by313

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 487 citations.

PMIDTitleJournalYearIn PapersSource
42,952,208Beyond Receptor-Proximal Uncoupling: EGFR-PKC Signaling and Arrestin Deubiquitination-Coupled Nuclear Trafficking in GPCR Signaling Regulation.Biomol Ther (Seoul)2026https://conductscience.org/library/papers/42952208PubMed
42,846,980Endosomes: An underappreciated player in cell signal transduction.Fundam Res2026https://conductscience.org/library/papers/42846980PubMed
42,722,652Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42722652PubMed
42,637,706Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control.Cell Discov2026https://conductscience.org/library/papers/42637706PubMed
42,485,388Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.Proc Natl Acad Sci U S A2026https://conductscience.org/library/papers/42485388PubMed
42,469,195β-arrestin recruitment facilitates a direct association with G proteins.Nat Commun2026https://conductscience.org/library/papers/42469195PubMed
42,336,356Loss of caveolar A1 adenosine receptor signalling blunts anti-adrenergic control in heart failure.Cardiovasc Res2026https://conductscience.org/library/papers/42336356PubMed
42,236,056Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.Curr Top Dev Biol2026https://conductscience.org/library/papers/42236056PubMed
41,708,633Conformational biosensors delineate endosomal G protein regulation by GPCRs.Nat Commun2026https://conductscience.org/library/papers/41708633PubMed
41,659,515Phosphovariants of the canonical heterotrimeric Gα protein, GPA1, differentially affect G protein activity and Arabidopsis development.bioRxiv2026https://conductscience.org/library/papers/41659515PubMed

1 to 10 of 313

See all 313 cited by

Genes8

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CFP5,199PubTator's text mininghttps://conductscience.org/library/genes/5199NCBI Gene
EEA18,411PubTator's text mininghttps://conductscience.org/library/genes/8411NCBI Gene
GAST2,520PubTator's text mininghttps://conductscience.org/library/genes/2520NCBI Gene
POTEF728,378PubTator's text mininghttps://conductscience.org/library/genes/728378NCBI Gene
RAB7B338,382PubTator's text mininghttps://conductscience.org/library/genes/338382NCBI Gene
RAPGEF310,411PubTator's text mininghttps://conductscience.org/library/genes/10411NCBI Gene
TSHR7,253PubTator's text mininghttps://conductscience.org/library/genes/7253NCBI Gene
VASP7,408PubTator's text mininghttps://conductscience.org/library/genes/7408NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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