Paper · 19802384

Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells.

Zong F and 9 others. PLoS One, 2009. Cited by 65 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. Papers, record 19802384. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19802384

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells.; PubMed
Journal: PLoS One; PubMed
Year: 2009; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/19802384/; PubMed
DOI: https://doi.org/10.1371/journal.pone.0007346; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2750749/; PubMed
The journal: https://conductscience.org/library/journal-index/101285081; PubMed
Citations, by iCite: 65; iCite
Relative citation ratio, by iCite: 1.64; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Zong F	Fang
2	Fthenou E	Eleni
3	Wolmer N	Nina
4	Hollósi P	Péter
5	Kovalszky I	Ilona
6	Szilák L	László
7	Mogler C	Carolin
8	Nilsonne G	Gustav
9	Tzanakakis G	Georgios
10	Dobra K	Katalin

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cell Nucleus	Major topic
Fibroblast Growth Factor 2	Major topic
Gene Expression Regulation, Neoplastic	Major topic
Glucuronidase	Major topic
Mesoderm	Major topic
Neoplasms	Major topic
Receptor, Fibroblast Growth Factor, Type 1	Major topic
Syndecan-1	Major topic
Cell Line, Tumor
DNA Mutational Analysis
Green Fluorescent Proteins
Humans
Immunoprecipitation
Microscopy, Confocal
Models, Biological
Heparanase

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	10,716,625	Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions.	Int J Biochem Cell Biol	2000	https://conductscience.org/library/papers/10716625	PubMed
2	2,715,188	Control of cell division in hepatoma cells by exogenous heparan sulfate proteoglycan.	J Cell Physiol	1989	https://conductscience.org/library/papers/2715188	PubMed
3	8,798,749	Fibroblast growth factor-2 binds to the regulatory beta subunit of CK2 and directly stimulates CK2 activity toward nucleolin.	J Biol Chem	1996	https://conductscience.org/library/papers/8798749	PubMed
4	2,328,724	Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells.	EMBO J	1990	https://conductscience.org/library/papers/2328724	PubMed
5	14,711,376	Syndecans in tumor cell adhesion and signaling.	Reprod Biol Endocrinol	2004	https://conductscience.org/library/papers/14711376	PubMed
6	16,901,744	Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.	Int J Biochem Cell Biol	2006	https://conductscience.org/library/papers/16901744	PubMed
7	1,646,484	Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.	Science	1991	https://conductscience.org/library/papers/1646484	PubMed
8	9,010,219	Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells.	Oncogene	1997	https://conductscience.org/library/papers/9010219	PubMed
9	11,038,364	Dissection of a nuclear localization signal.	J Biol Chem	2001	https://conductscience.org/library/papers/11038364	PubMed
10	14,759,226	Intracellular proteoglycans.	Biochem J	2004	https://conductscience.org/library/papers/14759226	PubMed

1 to 10 of 47

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Cited by44

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 65 citations.

PMID	Title	Journal	Year	In Papers	Source
41,832,306	FGF family in health and disease.	Mol Biomed	2026	https://conductscience.org/library/papers/41832306	PubMed
40,093,586	Heparan sulfate chains in hepatocellular carcinoma.	Gastroenterol Rep (Oxf)	2025	https://conductscience.org/library/papers/40093586	PubMed
39,688,651	Syndecan-1: a key player in health and disease.	Immunogenetics	2024	https://conductscience.org/library/papers/39688651	PubMed
37,762,403	The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour.	Int J Mol Sci	2023	https://conductscience.org/library/papers/37762403	PubMed
35,584,326	Targeting syndecan-1: new opportunities in cancer therapy.	Am J Physiol Cell Physiol	2022	https://conductscience.org/library/papers/35584326	PubMed
35,118,073	The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug Resistance.	Front Cell Dev Biol	2021	https://conductscience.org/library/papers/35118073	PubMed
34,730,792	An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens.	Invest Ophthalmol Vis Sci	2021	https://conductscience.org/library/papers/34730792	PubMed
34,671,250	The Unifying Hypothesis of Alzheimer's Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago.	Front Aging Neurosci	2021	https://conductscience.org/library/papers/34671250	PubMed
34,208,075	Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells.	Biology (Basel)	2021	https://conductscience.org/library/papers/34208075	PubMed
34,068,954	Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling.	Cells	2021	https://conductscience.org/library/papers/34068954	PubMed

1 to 10 of 44

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Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
FGF2	2,247	PubTator's text mining	https://conductscience.org/library/genes/2247	NCBI Gene
FGFR1	2,260	PubTator's text mining	https://conductscience.org/library/genes/2260	NCBI Gene
HPSE	10,855	PubTator's text mining	https://conductscience.org/library/genes/10855	NCBI Gene
SDC1	6,382	PubTator's text mining	https://conductscience.org/library/genes/6382	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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