Paper · 20056790

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.

Smith AC and 12 others. Blood, 2010. Cited by 103 papers, by iCite.

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ConductScience Library. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Papers, record 20056790. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20056790

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.; PubMed
Journal: Blood; PubMed
Year: 2010; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/20056790/; PubMed
DOI: https://doi.org/10.1182/blood-2009-10-246488; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2858492/; PubMed
The journal: https://conductscience.org/library/journal-index/7603509; PubMed
Citations, by iCite: 103; iCite
Relative citation ratio, by iCite: 2.06; iCite
Revised in PubMed: 2021-10-20; PubMed

Authors13

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Smith AC	Alexandra C H
2	Raimondi AR	Aubrey R
3	Salthouse CD	Chris D
4	Ignatius MS	Myron S
5	Blackburn JS	Jessica S
6	Mizgirev IV	Igor V
7	Storer NY	Narie Y
8	de Jong JL	Jill L O
9	Chen AT	Aye T
10	Zhou Y	Yi

1 to 10 of 13Source PubMed

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Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Disease Models, Animal	Major topic
Neoplasm Transplantation	Major topic
Neoplastic Stem Cells	Major topic
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Major topic
Zebrafish	Major topic
Animals
Animals, Genetically Modified
Cell Separation
Flow Cytometry
Image Processing, Computer-Assisted
Microscopy, Fluorescence

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
5 R01 CA103846-04	NCI NIH HHS	United States	R01CA103846	PubMed and NIH	NIH RePORTER
T32 GM007753	NIGMS NIH HHS	United States	T32GM007753	PubMed and NIH	NIH RePORTER
R01 CA103846	NCI NIH HHS	United States	R01CA103846	PubMed and NIH	NIH RePORTER
3 K01 AR055619-03S1	NIAMS NIH HHS	United States	K01AR055619	PubMed and NIH	NIH RePORTER
K01 AR055619-01A1	NIAMS NIH HHS	United States	K01AR055619	PubMed and NIH	NIH RePORTER
K01 AR055619	NIAMS NIH HHS	United States	K01AR055619	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	15,472,075	Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.	Science	2004	https://conductscience.org/library/papers/15472075	PubMed
2	17,114,293	NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.	Proc Natl Acad Sci U S A	2006	https://conductscience.org/library/papers/17114293	PubMed
3	19,516,274	Heritable T-cell malignancy models established in a zebrafish phenotypic screen.	Leukemia	2009	https://conductscience.org/library/papers/19516274	PubMed
4	17,510,286	Effects of RAS on the genesis of embryonal rhabdomyosarcoma.	Genes Dev	2007	https://conductscience.org/library/papers/17510286	PubMed
5	14,582,078	Gene expression profiling in T-cell acute lymphoblastic leukemia.	Semin Hematol	2003	https://conductscience.org/library/papers/14582078	PubMed
6	18,345,029	Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.	Oncogene	2008	https://conductscience.org/library/papers/18345029	PubMed
7	17,641,192	Tumor growth need not be driven by rare cancer stem cells.	Science	2007	https://conductscience.org/library/papers/17641192	PubMed
8	16,540,662	Transplantable tumor lines generated in clonal zebrafish.	Cancer Res	2006	https://conductscience.org/library/papers/16540662	PubMed
9	15,142,873	Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.	Blood	2004	https://conductscience.org/library/papers/15142873	PubMed
10	18,372,910	Catch of the day: zebrafish as a human cancer model.	Oncogene	2008	https://conductscience.org/library/papers/18372910	PubMed

1 to 10 of 28

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Cited by81

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 103 citations.

PMID	Title	Journal	Year	In Papers	Source
42,879,028	Using Zebrafish Larvae as a Xenotransplantation Model to Study Ewing Sarcoma.	Methods Mol Biol	2027	https://conductscience.org/library/papers/42879028	PubMed
42,802,717	Zebrafish against cancer: towards clinical relevance.	Dis Model Mech	2026	https://conductscience.org/library/papers/42802717	PubMed
42,699,572	MAPK-driven MYC/p21 axis controls senescence bypass and BCL-XL dependence in vincristine-resistant rhabdomyosarcoma.	iScience	2026	https://conductscience.org/library/papers/42699572	PubMed
39,216,481	A conserved transcription factor regulatory program promotes tendon fate.	Dev Cell	2024	https://conductscience.org/library/papers/39216481	PubMed
39,052,000	A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo.	Elife	2024	https://conductscience.org/library/papers/39052000	PubMed
38,656,392	Dynamic Changes in Lymphocyte Populations Establish Zebrafish as a Thymic Involution Model.	J Immunol	2024	https://conductscience.org/library/papers/38656392	PubMed
38,104,416	Zebrafish drug screening identifies Erlotinib as an inhibitor of Wnt/β-catenin signaling and self-renewal in T-cell acute lymphoblastic leukemia.	Biomed Pharmacother	2024	https://conductscience.org/library/papers/38104416	PubMed
37,188,201	Tumor heterogeneity: preclinical models, emerging technologies, and future applications.	Front Oncol	2023	https://conductscience.org/library/papers/37188201	PubMed
37,179,373	Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes.	Sci Rep	2023	https://conductscience.org/library/papers/37179373	PubMed
36,428,753	Targeting Leukemia-Initiating Cells and Leukemic Niches: The Next Therapy Station for T-Cell Acute Lymphoblastic Leukemia?	Cancers (Basel)	2022	https://conductscience.org/library/papers/36428753	PubMed

1 to 10 of 81

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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