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Paper2010544

Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes.

Lord PC and 3 others. J Clin Invest, 1991. Cited by 164 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes. Papers, record 2010544. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2010544

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes.
PubMed
Journal
J Clin Invest
PubMed
Year
1991
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
164
iCite
Relative citation ratio, by iCite
4.26
iCite
Revised in PubMed
2018-11-13
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lord PCP C
2Wilmoth LML M
3Mizel SBS B
4McCall CEC E

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Interleukin-1Major topic
NeutrophilsMajor topic
Base Sequence
Biological Assay
Blotting, Northern
Enzyme-Linked Immunosorbent Assay
Gene Expression
Humans
Immunohistochemistry
In Vitro Techniques
Leukocytes, Mononuclear
Lipopolysaccharides
Molecular Sequence Data
Oligonucleotides
Polymerase Chain Reaction
Protein Biosynthesis
RNA, Messenger

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI-09169NIAID NIH HHSUnited StatesR01AI009169PubMed and NIHNIH RePORTER
AI-25836NIAID NIH HHSUnited StatesR01AI025836PubMed and NIHNIH RePORTER
R21AI009169NIHNIH RePORTER

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,106,490The development of neutrophilic polymorphonuclear leukocytes in human bone marrow.J Exp Med1971https://conductscience.org/library/papers/4106490PubMed
3200,699Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors.J Exp Med1977https://conductscience.org/library/papers/200699PubMed
4103,631The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells.Cell1978https://conductscience.org/library/papers/103631PubMed
56,602,206Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor.J Exp Med1983https://conductscience.org/library/papers/6602206PubMed
66,362,752Polymorphonuclear leukocyte elastase activity is increased by bacterial lipopolysaccharide: a response inhibited by glucocorticoids.Blood1984https://conductscience.org/library/papers/6362752PubMed
76,500,626Production of a lymphocyte proliferation potentiating factor by purified polymorphonuclear leucocytes from mice and rabbits.Immunology1984https://conductscience.org/library/papers/6500626PubMed
83,874,231Production of interleukin 1 activity by normal human peripheral blood B lymphocytes.J Immunol1985https://conductscience.org/library/papers/3874231PubMed
92,989,698Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.Nature1985https://conductscience.org/library/papers/2989698PubMed
102,933,048Interleukin 1: an immunological perspective.Annu Rev Immunol1985https://conductscience.org/library/papers/2933048PubMed
113,084,639Interleukin 1 production by human polymorphonuclear neutrophils.J Immunol1986https://conductscience.org/library/papers/3084639PubMed
123,486,218Normal human neutrophils are a source of a specific interleukin 1 inhibitor.J Immunol1986https://conductscience.org/library/papers/3486218PubMed
133,754,653Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.Science1986https://conductscience.org/library/papers/3754653PubMed
143,492,551Studies on the molecular nature of human interleukin 1.J Immunol1987https://conductscience.org/library/papers/3492551PubMed
153,818,588Fibronectin gene expression in polymorphonuclear leukocytes. Accumulation of mRNA in inflammatory cells.J Biol Chem1987https://conductscience.org/library/papers/3818588PubMed
163,033,074Human recombinant interleukin 1 beta has no effect on intracellular calcium or on functional responses of human neutrophils.J Immunol1987https://conductscience.org/library/papers/3033074PubMed
172,437,239Heat-shock protein synthesis by human polymorphonuclear cells.J Exp Med1987https://conductscience.org/library/papers/2437239PubMed
183,495,571Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.J Immunol1987https://conductscience.org/library/papers/3495571PubMed
193,497,982Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.J Immunol1987https://conductscience.org/library/papers/3497982PubMed
203,668,972Protein biosynthetic activity of polymorphonuclear leukocytes in inflammatory arthropathies. Increased synthesis and release of fibronectin.J Rheumatol1987https://conductscience.org/library/papers/3668972PubMed
213,500,253Potentiation of neutrophil function by recombinant DNA-produced interleukin 1a.J Leukoc Biol1987https://conductscience.org/library/papers/3500253PubMed

See all 29 references

Cited by44

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 164 citations.

PMIDTitleJournalYearIn PapersSource
40,540,748Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone.Blood2025https://conductscience.org/library/papers/40540748PubMed
35,743,867Monocyte Chemotactic Proteins Mediate the Effects of Hyperglycemia in Chondrocytes: In Vitro Studies.Life (Basel)2022https://conductscience.org/library/papers/35743867PubMed
30,150,638Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome.Sci Rep2018https://conductscience.org/library/papers/30150638PubMed
29,872,287Blood MCP-1 levels are increased in chronic obstructive pulmonary disease patients with prevalent emphysema.Int J Chron Obstruct Pulmon Dis2018https://conductscience.org/library/papers/29872287PubMed
28,620,081Re-Examining Neutrophil Participation in GN.J Am Soc Nephrol2017https://conductscience.org/library/papers/28620081PubMed
28,303,118Potential Role of Chemokines in Fracture Repair.Front Endocrinol (Lausanne)2017https://conductscience.org/library/papers/28303118PubMed
27,785,664Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs.Inflammation2017https://conductscience.org/library/papers/27785664PubMed
27,752,292Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis.Clin Epigenetics2016https://conductscience.org/library/papers/27752292PubMed
27,452,044α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide induced IL-1β in human blood neutrophils.Mol Med2016https://conductscience.org/library/papers/27452044PubMed
25,548,252An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.J Leukoc Biol2015https://conductscience.org/library/papers/25548252PubMed
25,238,536Association of cytokines in individuals sensitive and insensitive to dust mites in a Brazilian population.PLoS One2014https://conductscience.org/library/papers/25238536PubMed
24,812,504Cytokine inhibition in the treatment of COPD.Int J Chron Obstruct Pulmon Dis2014https://conductscience.org/library/papers/24812504PubMed
23,284,088Editorial: Gazing forward while looking back.J Leukoc Biol2013https://conductscience.org/library/papers/23284088PubMed
22,022,727Circulating cytokine levels, Epstein-Barr viremia, and risk of acquired immunodeficiency syndrome-related non-Hodgkin lymphoma.Am J Hematol2011https://conductscience.org/library/papers/22022727PubMed
21,461,237Microarray Analysis of Gene Expression Profiles in Response to Treatment with Melatonin in Lipopolysaccharide Activated RAW 264.7 Cells.Korean J Physiol Pharmacol2011https://conductscience.org/library/papers/21461237PubMed
20,191,628Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.Arthritis Rheum2010https://conductscience.org/library/papers/20191628PubMed
19,393,603Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation.Cell Immunol2009https://conductscience.org/library/papers/19393603PubMed
18,472,818Role of cytokines in myocardial ischemia and reperfusion.Mediators Inflamm1997https://conductscience.org/library/papers/18472818PubMed
15,509,550The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.Am J Pathol2004https://conductscience.org/library/papers/15509550PubMed
12,140,751IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS).Genes Immun2002https://conductscience.org/library/papers/12140751PubMed

See all 44 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
IL1A3,552PubTator's text mininghttps://conductscience.org/library/genes/3552NCBI Gene
IL1B3,553PubTator's text mininghttps://conductscience.org/library/genes/3553NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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