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Paper · 21428443

Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.

Huang F and 5 others. ACS Chem Biol, 2011. Cited by 186 papers, by iCite.

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ConductScience Library. Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. Papers, record 21428443. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21428443

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.
PubMed
Journal
ACS Chem Biol
PubMed
Year
2011
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
186
iCite
Relative citation ratio, by iCite
3.89
iCite
Revised in PubMed
2025-10-22
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Huang FFei
2Motlekar NANuzhat A
3Burgwin CMChelsea M
4Napper ADAndrew D
5Diamond SLScott L
6Mazin AVAlexander V

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Enzyme InhibitorsMajor topic
High-Throughput Screening AssaysMajor topic
QuinazolinonesMajor topic
Rad51 RecombinaseMajor topic
Fluorescence Resonance Energy Transfer
Humans
Molecular Structure
Small Molecule Libraries
Stereoisomerism
Structure-Activity Relationship

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
CA100839NCI NIH HHSUnited StatesR01CA100839PubMed and NIHNIH RePORTER
U54 HG003915NHGRI NIH HHSUnited StatesU54HG003915PubMed and NIHNIH RePORTER
U54-HG003915NHGRI NIH HHSUnited StatesU54HG003915PubMed and NIHNIH RePORTER
MH084119NIMH NIH HHSUnited StatesR03MH084119PubMed and NIHNIH RePORTER
R01 CA100839NCI NIH HHSUnited StatesR01CA100839PubMed and NIHNIH RePORTER
R56 CA100839NCI NIH HHSUnited StatesR01CA100839PubMed and NIHNIH RePORTER
R03 MH084119NIMH NIH HHSUnited StatesR03MH084119PubMed and NIHNIH RePORTER
R56CA100839NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1156,361Purified Escherichia coli recA protein catalyzes homologous pairing of superhelical DNA and single-stranded fragments.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/156361PubMed
218,275,380Mechanism of eukaryotic homologous recombination.Annu Rev Biochem2008https://conductscience.org/library/papers/18275380PubMed
38,929,543Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro.Cell1996https://conductscience.org/library/papers/8929543PubMed
49,430,650Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death.EMBO J1998https://conductscience.org/library/papers/9430650PubMed
517,545,145Interactions of human rad54 protein with branched DNA molecules.J Biol Chem2007https://conductscience.org/library/papers/17545145PubMed
618,497,811Structural biology: snapshots of DNA repair.Nature2008https://conductscience.org/library/papers/18497811PubMed
715,226,506Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity.Proc Natl Acad Sci U S A2004https://conductscience.org/library/papers/15226506PubMed
811,782,381Elevated levels of Rad51 recombination protein in tumor cells.Cancer Res2002https://conductscience.org/library/papers/11782381PubMed
916,862,129Rad54 protein promotes branch migration of Holliday junctions.Nature2006https://conductscience.org/library/papers/16862129PubMed
1020,089,461Rad54, the motor of homologous recombination.DNA Repair (Amst)2010https://conductscience.org/library/papers/20089461PubMed

1 to 10 of 30

See all 30 references

Cited by141

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 186 citations.

PMIDTitleJournalYearIn PapersSource
42,497,248BRCA1-RAD51 homologous DNA repair pathway promotes HIV-1 reverse transcription.Sci Adv2026https://conductscience.org/library/papers/42497248PubMed
42,490,812RAD51 in Breast Cancer: From Vulnerability to Resistance.World J Oncol2026https://conductscience.org/library/papers/42490812PubMed
42,368,572RAD51-targeting small molecule degrader sensitizes BRCA-proficient prostate cancer cells to PARP inhibitors via synthetic lethality.Acta Pharm Sin B2026https://conductscience.org/library/papers/42368572PubMed
42,169,779Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma.Research (Wash D C)2026https://conductscience.org/library/papers/42169779PubMed
42,109,249TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Nucleic Acids Res2026https://conductscience.org/library/papers/42109249PubMed
41,514,018RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress.Nat Cell Biol2026https://conductscience.org/library/papers/41514018PubMed
41,420,106Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities.EMBO Mol Med2026https://conductscience.org/library/papers/41420106PubMed
41,372,167SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress.Nat Commun2025https://conductscience.org/library/papers/41372167PubMed
41,365,890Efficient high-precision transgene knock-in by Recombinases (Redα/β)-enhanced DNA integration-CRISPR-Cas9 (RED-CRISPR).Nat Commun2025https://conductscience.org/library/papers/41365890PubMed
41,190,241Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors.NAR Cancer2025https://conductscience.org/library/papers/41190241PubMed

1 to 10 of 141

See all 141 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
RAD515,888PubTator's text mininghttps://conductscience.org/library/genes/5888NCBI Gene
RAD54L8,438PubTator's text mininghttps://conductscience.org/library/genes/8438NCBI Gene
SMARCA46,597PubTator's text mininghttps://conductscience.org/library/genes/6597NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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