Paper23166319
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Pohar J and 4 others. J Biol Chem, 2013. Cited by 57 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. Papers, record 23166319. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23166319
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
- PubMed
Topics17
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Gene Expression Regulation | Major topic |
| Membrane Transport Proteins | Major topic |
| Nucleic Acids | Major topic |
| Toll-Like Receptor 3 | Major topic |
| Cell Membrane | |
| Cell Separation | |
| Endothelial Cells | |
| Flow Cytometry | |
| Glycosylation | |
| HEK293 Cells | |
| Humans | |
| Interferon-beta | |
| Poly I-C | |
| RNA Interference | |
| Toll-Like Receptor 9 | |
| Transcription, Genetic | |
| Up-Regulation |
Source PubMed
References57
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 16,858,407 | Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. | EMBO J | 2006 | https://conductscience.org/library/papers/16858407 | PubMed |
| 2 | 18,089,727 | Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. | J Gen Virol | 2008 | https://conductscience.org/library/papers/18089727 | PubMed |
| 3 | 22,865,861 | Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization. | J Biol Chem | 2012 | https://conductscience.org/library/papers/22865861 | PubMed |
| 4 | 18,305,481 | UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. | Nature | 2008 | https://conductscience.org/library/papers/18305481 | PubMed |
| 5 | 14,716,310 | TLR9 signals after translocating from the ER to CpG DNA in the lysosome. | Nat Immunol | 2004 | https://conductscience.org/library/papers/14716310 | PubMed |
| 6 | 370,792 | Long double-stranded sequences (dsRNA-B) of nuclear pre-mRNA consist of a few highly abundant classes of sequences: evidence from DNA cloning experiments. | Nucleic Acids Res | 1979 | https://conductscience.org/library/papers/370792 | PubMed |
| 7 | 18,172,197 | The TLR3 signaling complex forms by cooperative receptor dimerization. | Proc Natl Acad Sci U S A | 2008 | https://conductscience.org/library/papers/18172197 | PubMed |
| 8 | 17,202,381 | MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. | J Immunol | 2007 | https://conductscience.org/library/papers/17202381 | PubMed |
| 9 | 16,341,217 | Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. | Nat Immunol | 2006 | https://conductscience.org/library/papers/16341217 | PubMed |
| 10 | 20,159,909 | Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus. | Rheumatology (Oxford) | 2010 | https://conductscience.org/library/papers/20159909 | PubMed |
| 11 | 17,873,860 | Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. | Nature | 2007 | https://conductscience.org/library/papers/17873860 | PubMed |
| 12 | 16,533,755 | Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation. | J Biol Chem | 2006 | https://conductscience.org/library/papers/16533755 | PubMed |
| 13 | 12,855,817 | Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. | Science | 2003 | https://conductscience.org/library/papers/12855817 | PubMed |
| 14 | 21,683,627 | Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking. | Immunity | 2011 | https://conductscience.org/library/papers/21683627 | PubMed |
| 15 | 19,428,918 | TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity. | Vaccine | 2009 | https://conductscience.org/library/papers/19428918 | PubMed |
| 16 | 9,799,232 | CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. | EMBO J | 1998 | https://conductscience.org/library/papers/9799232 | PubMed |
| 17 | 15,961,631 | Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. | Science | 2005 | https://conductscience.org/library/papers/15961631 | PubMed |
| 18 | 16,990,271 | Cytoplasmic targeting motifs control localization of toll-like receptor 9. | J Biol Chem | 2006 | https://conductscience.org/library/papers/16990271 | PubMed |
| 19 | 16,973,841 | Herpes simplex virus encephalitis in human UNC-93B deficiency. | Science | 2006 | https://conductscience.org/library/papers/16973841 | PubMed |
| 20 | 14,982,987 | Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. | Proc Natl Acad Sci U S A | 2004 | https://conductscience.org/library/papers/14982987 | PubMed |
Cited by34
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 57 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 40,440,055 | An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines. | Protein Cell | 2024 | https://conductscience.org/library/papers/40440055 | PubMed |
| 39,457,048 | Immunity and Coagulation in COVID-19. | Int J Mol Sci | 2024 | https://conductscience.org/library/papers/39457048 | PubMed |
| 39,143,032 | Sterile activation of RNA-sensing pathways in autoimmunity. | J Mol Cell Biol | 2024 | https://conductscience.org/library/papers/39143032 | PubMed |
| 35,269,457 | Combined TLR-3/TLR-8 Signaling in the Presence of α-Type-1 Cytokines Represents a Novel and Potent Dendritic Cell Type-1, Anti-Cancer Maturation Protocol. | Cells | 2022 | https://conductscience.org/library/papers/35269457 | PubMed |
| 34,815,573 | Cellular origins of dsRNA, their recognition and consequences. | Nat Rev Mol Cell Biol | 2022 | https://conductscience.org/library/papers/34815573 | PubMed |
| 34,589,086 | UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b. | Front Immunol | 2021 | https://conductscience.org/library/papers/34589086 | PubMed |
| 33,597,952 | Cell Surface Expression of Endosomal Toll-Like Receptors-A Necessity or a Superfluous Duplication? | Front Immunol | 2020 | https://conductscience.org/library/papers/33597952 | PubMed |
| 33,281,554 | Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes. | Front Cell Neurosci | 2020 | https://conductscience.org/library/papers/33281554 | PubMed |
| 32,668,228 | Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids. | Immunity | 2020 | https://conductscience.org/library/papers/32668228 | PubMed |
| 32,668,226 | Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity. | Immunity | 2020 | https://conductscience.org/library/papers/32668226 | PubMed |
| 32,185,237 | The Response of Tissue Mast Cells to TLR3 Ligand Poly(I:C) Treatment. | J Immunol Res | 2020 | https://conductscience.org/library/papers/32185237 | PubMed |
| 31,892,731 | Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization. | Sci Rep | 2019 | https://conductscience.org/library/papers/31892731 | PubMed |
| 31,355,260 | Expression Profiles of Long Noncoding RNA and mRNA in Epicardial Adipose Tissue in Patients with Heart Failure. | Biomed Res Int | 2019 | https://conductscience.org/library/papers/31355260 | PubMed |
| 30,613,350 | Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues. | Oncotarget | 2018 | https://conductscience.org/library/papers/30613350 | PubMed |
| 30,526,333 | Activation of Innate Immune Responses by a CpG Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid. | Nucleic Acid Ther | 2019 | https://conductscience.org/library/papers/30526333 | PubMed |
| 29,988,708 | New application of anti-TLR monoclonal antibodies: detection, inhibition and protection. | Inflamm Regen | 2018 | https://conductscience.org/library/papers/29988708 | PubMed |
| 29,768,176 | The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. | Immunity | 2018 | https://conductscience.org/library/papers/29768176 | PubMed |
| 28,717,003 | Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness. | J Biol Chem | 2017 | https://conductscience.org/library/papers/28717003 | PubMed |
| 28,215,278 | Nucleic Acid Immunity. | Adv Immunol | 2017 | https://conductscience.org/library/papers/28215278 | PubMed |
| 27,343,013 | Molecular mechanisms of regulation of Toll-like receptor signaling. | J Leukoc Biol | 2016 | https://conductscience.org/library/papers/27343013 | PubMed |
Genes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| TLR3 | 7,098 | PubTator's text mining | https://conductscience.org/library/genes/7098 | NCBI Gene |
| TLR9 | 54,106 | PubTator's text mining | https://conductscience.org/library/genes/54106 | NCBI Gene |
| UNC93B1 | 81,622 | PubTator's text mining | https://conductscience.org/library/genes/81622 | NCBI Gene |
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The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
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- Trials
- Comments and corrections
- Drugs
- Data
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- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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