Paper · 23630438
Lef1 contributes to the differentiation of bulge stem cells by nuclear translocation and cross-talk with the Notch signaling pathway.
Zhang Y and 6 others. Int J Med Sci, 2013. Cited by 48 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Lef1 contributes to the differentiation of bulge stem cells by nuclear translocation and cross-talk with the Notch signaling pathway. Papers, record 23630438. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23630438
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Lef1 contributes to the differentiation of bulge stem cells by nuclear translocation and cross-talk with the Notch signaling pathway.
- PubMed
Topics12
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Cell Differentiation | Major topic |
| Hair Follicle | Major topic |
| Lymphoid Enhancer-Binding Factor 1 | Major topic |
| Stem Cells | Major topic |
| Animals | |
| Cell Nucleus | |
| Gene Expression Regulation, Developmental | |
| Protein Transport | |
| Rats | |
| Receptors, Notch | |
| Wnt Signaling Pathway | |
| beta Catenin |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References44
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 22,417,309 | Hair-inducing ability of human dermal papilla cells cultured under Wnt/β-catenin signalling activation. | Exp Dermatol | 2012 | https://conductscience.org/library/papers/22417309 | PubMed |
| 2 | 21,621,827 | The expression and role of c-Myc in mouse hair follicle morphogenesis and cycling. | Acta Histochem | 2012 | https://conductscience.org/library/papers/21621827 | PubMed |
| 3 | 15,292,489 | Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin. | Physiol Genomics | 2004 | https://conductscience.org/library/papers/15292489 | PubMed |
| 4 | 12,502,739 | FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. | Genes Dev | 2002 | https://conductscience.org/library/papers/12502739 | PubMed |
| 5 | 2,364,430 | Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. | Cell | 1990 | https://conductscience.org/library/papers/2364430 | PubMed |
| 6 | 10,804,183 | Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. | Development | 2000 | https://conductscience.org/library/papers/10804183 | PubMed |
| 7 | 16,378,739 | Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells. | Cell Biol Int | 2006 | https://conductscience.org/library/papers/16378739 | PubMed |
| 8 | 15,245,424 | Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. | J Invest Dermatol | 2004 | https://conductscience.org/library/papers/15245424 | PubMed |
| 9 | 10,878,608 | Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators. | Dev Dyn | 2000 | https://conductscience.org/library/papers/10878608 | PubMed |
| 10 | 15,936,755 | Beta-catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1). | Exp Cell Res | 2005 | https://conductscience.org/library/papers/15936755 | PubMed |
1 to 10 of 44
See all 44 referencesCited by31
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 48 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,652,029 | N6-Methyladenosine (m6A)-circHECA Recruiting FUS Promotes Differentiation of SHF Stem Cells into Hair Follicle Lineages Through Stabilizing FOXM1 mRNA to Activate NOTCH Pathway in Cashmere Goats. | Animals (Basel) | 2026 | https://conductscience.org/library/papers/42652029 | PubMed |
| 42,128,033 | N6-methyladenosine (m6A)-circHECA facilitates the differentiation of SHF stem cells into hair follicle lineage through miR-449a-5p/LEF1 mediated Wnt/β-catenin pathway in cashmere goats. | Anim Biosci | 2026 | https://conductscience.org/library/papers/42128033 | PubMed |
| 42,074,048 | Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail-Implications for Disease and Regeneration. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/42074048 | PubMed |
| 41,998,142 | A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin. | Exp Mol Med | 2026 | https://conductscience.org/library/papers/41998142 | PubMed |
| 41,948,080 | Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation. | Front Cell Dev Biol | 2026 | https://conductscience.org/library/papers/41948080 | PubMed |
| 39,970,235 | Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model. | Sci Transl Med | 2025 | https://conductscience.org/library/papers/39970235 | PubMed |
| 39,900,922 | A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions. | Nat Commun | 2025 | https://conductscience.org/library/papers/39900922 | PubMed |
| 39,623,320 | Transcriptomic analysis of regulatory mechanisms in the telogen-anagen transition of ovine hair follicles. | BMC Genomics | 2024 | https://conductscience.org/library/papers/39623320 | PubMed |
| 39,210,824 | N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter. | Anim Biosci | 2024 | https://conductscience.org/library/papers/39210824 | PubMed |
| 39,194,698 | Ontogeny of Skin Stem Cells and Molecular Underpinnings. | Curr Issues Mol Biol | 2024 | https://conductscience.org/library/papers/39194698 | PubMed |
1 to 10 of 31
See all 31 cited byGenes7
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CTNNB1 | 1,499 | PubTator's text mining | https://conductscience.org/library/genes/1499 | NCBI Gene |
| HNF4A | 3,172 | PubTator's text mining | https://conductscience.org/library/genes/3172 | NCBI Gene |
| JAG1 | 182 | PubTator's text mining | https://conductscience.org/library/genes/182 | NCBI Gene |
| LEF1 | 51,176 | PubTator's text mining | https://conductscience.org/library/genes/51176 | NCBI Gene |
| MYC | 4,609 | PubTator's text mining | https://conductscience.org/library/genes/4609 | NCBI Gene |
| NOTCH1 | 4,851 | PubTator's text mining | https://conductscience.org/library/genes/4851 | NCBI Gene |
| SRPRA | 6,734 | PubTator's text mining | https://conductscience.org/library/genes/6734 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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