ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 24831703

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.

Sarbajna S and 2 others. Genes Dev, 2014. Cited by 119 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. Papers, record 24831703. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24831703

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.
PubMed
Journal
Genes Dev
PubMed
Year
2014
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
119
iCite
Relative citation ratio, by iCite
2.77
iCite
Revised in PubMed
2025-05-29
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sarbajna SShriparna
2Davies DDerek
3West SCStephen C

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Genomic InstabilityMajor topic
MitosisMajor topic
Anaphase
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Nucleus
Centromere
Chromosome Aberrations
Chromosomes
DNA Breaks
HeLa Cells
Humans
Indoles
Micronuclei, Chromosome-Defective
Recombinases
Replication Origin

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
11582Cancer Research UKUnited KingdomPubMed
2009MAYPR01Breast Cancer NowUnited KingdomPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,140,506A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4140506PubMed
221,317,88353BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.Nat Cell Biol2011https://conductscience.org/library/papers/21317883PubMed
318,054,789Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.J Mol Biol2008https://conductscience.org/library/papers/18054789PubMed
417,599,064BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.EMBO J2007https://conductscience.org/library/papers/17599064PubMed
521,399,624Aberrant chromosome morphology in human cells defective for Holliday junction resolution.Nature2011https://conductscience.org/library/papers/21399624PubMed
622,907,656The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4.Hum Mol Genet2012https://conductscience.org/library/papers/22907656PubMed
720,386,692Emergence of micronuclei and their effects on the fate of cells under replication stress.PLoS One2010https://conductscience.org/library/papers/20386692PubMed
817,636,031Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast.Mol Cell Biol2007https://conductscience.org/library/papers/17636031PubMed
923,811,685MUS81 promotes common fragile site expression.Nat Cell Biol2013https://conductscience.org/library/papers/23811685PubMed
1015,548,689Ionizing radiation induces frequent translocations with delayed replication and condensation.Cancer Res2004https://conductscience.org/library/papers/15548689PubMed

1 to 10 of 40

See all 40 references

Cited by88

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 119 citations.

PMIDTitleJournalYearIn PapersSource
42,327,041Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens.bioRxiv2026https://conductscience.org/library/papers/42327041PubMed
42,313,851Towards a unified model of aneuploid karyotype dynamics.PLoS Genet2026https://conductscience.org/library/papers/42313851PubMed
42,312,488The ultrafine-bridge-associated endonuclease ANKLE1 is stimulated by tension in DNA to process branch-points.Nucleic Acids Res2026https://conductscience.org/library/papers/42312488PubMed
41,888,103Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal Transduct Target Ther2026https://conductscience.org/library/papers/41888103PubMed
41,841,343Dual-site phosphorylation of SLX4 stabilizes the SLX4-MUS81 interface to promote mitotic SMX assembly and genome protection.Nucleic Acids Res2026https://conductscience.org/library/papers/41841343PubMed
41,740,057Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells.J Med Chem2026https://conductscience.org/library/papers/41740057PubMed
41,370,868How DNA secondary structures drive replication fork instability.DNA Repair (Amst)2025https://conductscience.org/library/papers/41370868PubMed
41,361,016ANKLE1 processes chromatin bridges by cleaving mechanically stressed DNA.Nat Commun2025https://conductscience.org/library/papers/41361016PubMed
41,242,522Mismatch repair disturbs meiotic crossover control in S. cerevisiae.Nucleic Acids Res2025https://conductscience.org/library/papers/41242522PubMed
40,025,590Multiple functions of the ALT favorite helicase, BLM.Cell Biosci2025https://conductscience.org/library/papers/40025590PubMed

1 to 10 of 88

See all 88 cited by

Genes20

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
BLM641PubTator's text mininghttps://conductscience.org/library/genes/641NCBI Gene
CCNA2890PubTator's text mininghttps://conductscience.org/library/genes/890NCBI Gene
CHEK11,111PubTator's text mininghttps://conductscience.org/library/genes/1111NCBI Gene
CHEK211,200PubTator's text mininghttps://conductscience.org/library/genes/11200NCBI Gene
EME1146,956PubTator's text mininghttps://conductscience.org/library/genes/146956NCBI Gene
FANCD22,177PubTator's text mininghttps://conductscience.org/library/genes/2177NCBI Gene
FANCI55,215PubTator's text mininghttps://conductscience.org/library/genes/55215NCBI Gene
GPR148344,561PubTator's text mininghttps://conductscience.org/library/genes/344561NCBI Gene
MUS8180,198PubTator's text mininghttps://conductscience.org/library/genes/80198NCBI Gene

1 to 10 of 20

See all 20 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/24831703

GET https://conductscience.org/api/papers/v1/24831703/references?page=2

API referenceFor AI assistants