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Paper · 25759020

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.

Atwood SX and 11 others. Cancer Cell, 2015. Cited by 347 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Smoothened variants explain the majority of drug resistance in basal cell carcinoma. Papers, record 25759020. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/25759020

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
PubMed
Journal
Cancer Cell
PubMed
Year
2015
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
347
iCite
Relative citation ratio, by iCite
10.2
iCite
Revised in PubMed
2026-01-28
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Atwood SXScott X
2Sarin KYKavita Y
3Whitson RJRamon J
4Li JRJiang R
5Kim GGeurim
6Rezaee MMelika
7Ally MSMina S
8Kim JJinah
9Yao CCatherine
10Chang ALAnne Lynn S

1 to 10 of 12Source PubMed

See all 12 authors

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AnilidesMajor topic
Basal Cell CarcinomaMajor topic
Drug Resistance, NeoplasmMajor topic
PyridinesMajor topic
Receptors, G-Protein-CoupledMajor topic
Skin NeoplasmsMajor topic
Binding Sites
DNA Mutational Analysis
Exome
Hedgehog Proteins
Humans
Models, Molecular
Mutation
Protein Structure, Tertiary
Sequence Analysis, DNA
Signal Transduction
Smoothened Receptor

Source PubMed

Grants10

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
2AR046786NIAMS NIH HHSUnited StatesR01AR046786PubMed and NIHNIH RePORTER
1K99CA176847NCI NIH HHSUnited StatesK99CA176847PubMed and NIHNIH RePORTER
R01 AR054780NIAMS NIH HHSUnited StatesR01AR054780PubMed and NIHNIH RePORTER
R00 CA176847NCI NIH HHSUnited StatesK99CA176847PubMed and NIHNIH RePORTER
R01 AR046786NIAMS NIH HHSUnited StatesR01AR046786PubMed and NIHNIH RePORTER
K99 CA176847NCI NIH HHSUnited StatesK99CA176847PubMed and NIHNIH RePORTER
R01 CA157895NCI NIH HHSUnited StatesR01CA157895PubMed and NIHNIH RePORTER
5ARO54780PHS HHSUnited StatesPubMedPubMed
R00CA176847NIHNIH RePORTER
T32CA009302NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in25,759,014Vismodegib resistance in basal cell carcinoma: not a smooth fit.https://conductscience.org/library/papers/25759014PubMed
Comment in25,813,347Smoothened mutations underlie Basal cell carcinoma resistance.https://conductscience.org/library/papers/25813347PubMed

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,885,213Activation of heterotrimeric G proteins by Smoothened.Proc Natl Acad Sci U S A2006https://conductscience.org/library/papers/16885213PubMed
220,881,279Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.Sci Transl Med2010https://conductscience.org/library/papers/20881279PubMed
324,077,351Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study.Clin Cancer Res2013https://conductscience.org/library/papers/24077351PubMed
424,973,920Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Nat Med2014https://conductscience.org/library/papers/24973920PubMed
518,516,045Mapping and quantifying mammalian transcriptomes by RNA-Seq.Nat Methods2008https://conductscience.org/library/papers/18516045PubMed
623,071,148Hedgehog pathway inhibition and the race against tumor evolution.J Cell Biol2012https://conductscience.org/library/papers/23071148PubMed
724,651,015Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.Cancer Cell2014https://conductscience.org/library/papers/24651015PubMed
823,515,405U.S. Food and Drug Administration approval: vismodegib for recurrent, locally advanced, or metastatic basal cell carcinoma.Clin Cancer Res2013https://conductscience.org/library/papers/23515405PubMed
923,446,420GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.Nature2013https://conductscience.org/library/papers/23446420PubMed
1022,869,526A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.Mol Cell Biol2012https://conductscience.org/library/papers/22869526PubMed

1 to 10 of 28

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Cited by233

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 347 citations.

PMIDTitleJournalYearIn PapersSource
42,120,706Transforming Outcomes in Advanced Basal Cell Carcinoma: The Evolving Role of Systemic Therapy.Am J Clin Dermatol2026https://conductscience.org/library/papers/42120706PubMed
42,092,773Decoding GPCR signaling reprogramming in cancer: molecular mechanisms and therapeutic implications.Mol Med2026https://conductscience.org/library/papers/42092773PubMed
42,019,316Nitric oxide generates a coordinated histone modification signature consistent with chromatin compaction, linked to methyl-modifying enzyme dysregulation and tumor-permissive gene silencing.Redox Biol2026https://conductscience.org/library/papers/42019316PubMed
42,000,925Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.Oncogene2026https://conductscience.org/library/papers/42000925PubMed
41,799,519Advances in Targeted and Immunotherapy for High-Risk Cutaneous Malignancies.Oncol Res2026https://conductscience.org/library/papers/41799519PubMed
41,657,480Clinical Outcomes of Sonidegib in Vismodegib-Exposed Locally Advanced Basal Cell Carcinoma: Insights From a Multicenter Descriptive Study.J Skin Cancer2026https://conductscience.org/library/papers/41657480PubMed
41,596,411Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors.Int J Mol Sci2026https://conductscience.org/library/papers/41596411PubMed
41,515,948Resistance to SMO Inhibitors in Advanced Basal Cell Carcinoma: A Case Highlighting the Role of Molecular Tumor Profiling.Int J Mol Sci2025https://conductscience.org/library/papers/41515948PubMed
41,460,725Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors.Cancer Res2026https://conductscience.org/library/papers/41460725PubMed
41,402,577Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors.Drug Deliv Transl Res2026https://conductscience.org/library/papers/41402577PubMed

1 to 10 of 233

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Genes14

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ADRA2B151PubTator's text mininghttps://conductscience.org/library/genes/151NCBI Gene
CAMP820PubTator's text mininghttps://conductscience.org/library/genes/820NCBI Gene
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
DNER92,737PubTator's text mininghttps://conductscience.org/library/genes/92737NCBI Gene
GLI12,735PubTator's text mininghttps://conductscience.org/library/genes/2735NCBI Gene
GLI22,736PubTator's text mininghttps://conductscience.org/library/genes/2736NCBI Gene
KRT143,861PubTator's text mininghttps://conductscience.org/library/genes/3861NCBI Gene
LBP3,929PubTator's text mininghttps://conductscience.org/library/genes/3929NCBI Gene
MYCN4,613PubTator's text mininghttps://conductscience.org/library/genes/4613NCBI Gene
PTCH15,727PubTator's text mininghttps://conductscience.org/library/genes/5727NCBI Gene

1 to 10 of 14

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE58377

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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