Paper · 30091661

Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.

Wirshing ACE and 1 other. Mol Biol Cell, 2018. Cited by 24 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca. Papers, record 30091661. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30091661

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.; PubMed
Journal: Mol Biol Cell; PubMed
Year: 2018; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/30091661/; PubMed
DOI: https://doi.org/10.1091/mbc.e18-06-0347; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6233056/; PubMed
The journal: https://conductscience.org/library/journal-index/9201390; PubMed
Citations, by iCite: 24; iCite
Relative citation ratio, by iCite: 0.84; iCite
Revised in PubMed: 2019-05-06; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Wirshing ACE	Alison C E
2	Cram EJ	Erin J

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Actins	Major topic
Caenorhabditis elegans	Major topic
Caenorhabditis elegans Proteins	Major topic
Spectrin	Major topic
Spermatozoa	Major topic
Actomyosin
Animals
Genetic Testing
Male
Ovulation

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R01 GM110268	NIGMS NIH HHS	United States	R01GM110268	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References131

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	26,551,084	Reactive protoplasmic and fibrous astrocytes contain high levels of calpain-cleaved alpha 2 spectrin.	Exp Mol Pathol	2016	https://conductscience.org/library/papers/26551084	PubMed
2	10,822,256	The Caenorhabditis elegans gonad: a test tube for cell and developmental biology.	Dev Dyn	2000	https://conductscience.org/library/papers/10822256	PubMed
3	16,937,397	Dual roles of tropomyosin as an F-actin stabilizer and a regulator of muscle contraction in Caenorhabditis elegans body wall muscle.	Cell Motil Cytoskeleton	2006	https://conductscience.org/library/papers/16937397	PubMed
4	17,326,220	Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.	Dev Dyn	2007	https://conductscience.org/library/papers/17326220	PubMed
5	17,266,121	A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans.	Genet Epidemiol	2007	https://conductscience.org/library/papers/17266121	PubMed
6	23,671,426	Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca.	PLoS Genet	2013	https://conductscience.org/library/papers/23671426	PubMed
7	20,707,996	FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans.	Dev Biol	2010	https://conductscience.org/library/papers/20707996	PubMed
8	22,159,418	Cell organization, growth, and neural and cardiac development require αII-spectrin.	J Cell Sci	2011	https://conductscience.org/library/papers/22159418	PubMed
9	27,770,600	INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans.	Cytoskeleton (Hoboken)	2016	https://conductscience.org/library/papers/27770600	PubMed
10	9,570,776	Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye.	Development	1998	https://conductscience.org/library/papers/9570776	PubMed

1 to 10 of 131

See all 131 references

Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 24 citations.

PMID	Title	Journal	Year	In Papers	Source
42,926,517	The single-PDZ domain protein TXBP-3 regulates contractility in the C. elegans spermatheca.	bioRxiv	2026	https://conductscience.org/library/papers/42926517	PubMed
41,993,515	PES-8 is required for Cytoskeletal Organization and Contractility in the C. elegans Spermatheca.	bioRxiv	2026	https://conductscience.org/library/papers/41993515	PubMed
41,195,540	Twinfilin modulates tissue contractility through uncapping of capping protein in C. elegans.	Development	2025	https://conductscience.org/library/papers/41195540	PubMed
41,023,811	Coupled transcriptome and proteome analysis of L3 and L4 developmental stages of Anisakis simplex s. s.: insights into target genes under glucose influence.	BMC Genomics	2025	https://conductscience.org/library/papers/41023811	PubMed
39,474,353	Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin.	Front Cell Dev Biol	2024	https://conductscience.org/library/papers/39474353	PubMed
38,349,741	A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans.	Development	2024	https://conductscience.org/library/papers/38349741	PubMed
37,587,694	TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.	Nucleic Acids Res	2023	https://conductscience.org/library/papers/37587694	PubMed
37,396,793	Apical-basal polarity of the spectrin cytoskeleton in the C. elegans vulva.	MicroPubl Biol	2023	https://conductscience.org/library/papers/37396793	PubMed
37,131,843	TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.	bioRxiv	2023	https://conductscience.org/library/papers/37131843	PubMed
36,219,157	β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis.	J Cell Biol	2023	https://conductscience.org/library/papers/36219157	PubMed

1 to 10 of 19

See all 19 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
FLNA	2,316	PubTator's text mining	https://conductscience.org/library/genes/2316	NCBI Gene
PLCG1	5,335	PubTator's text mining	https://conductscience.org/library/genes/5335	NCBI Gene
UTRN	7,402	PubTator's text mining	https://conductscience.org/library/genes/7402	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/30091661

GET https://conductscience.org/api/papers/v1/30091661/references?page=2

API reference For AI assistants