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Paper · 304527

Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

Zinkernagel RM and 3 others. Nature, 1978. Cited by 235 papers, by iCite.

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ConductScience Library. Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Papers, record 304527. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/304527

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.
PubMed
Journal
Nature
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
235
iCite
Relative citation ratio, by iCite
3.91
iCite
Revised in PubMed
2026-10-28
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zinkernagel RMR M
2Callahan GNG N
3Klein JJ
4Dennert GG

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cytotoxicity, ImmunologicMajor topic
H-2 AntigensMajor topic
T-LymphocytesMajor topic
Thymus GlandMajor topic
Animals
Binding Sites
Immune Tolerance
Mice
Radiation Chimera

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References11

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1300,847Y-antigen killing by T cells of women is restricted by HLA.Nature1977https://conductscience.org/library/papers/300847PubMed
2805,174Induction and properties of cytotoxic T cells specific for hapten-coupled tumor cells.J Immunol1975https://conductscience.org/library/papers/805174PubMed
34,547,543Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.Nature1974https://conductscience.org/library/papers/4547543PubMed
41,082,923Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.J Exp Med1976https://conductscience.org/library/papers/1082923PubMed
54,139,718Cellular immunity against Rous sarcomas of chickens. Preferential reactivity against autochthonous target cells as determined by lymphocyte adherence and cytotoxicity tests in vitro.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4139718PubMed
662,016H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.J Exp Med1976https://conductscience.org/library/papers/62016PubMed
7301,251Neonatally tolerant mice fail to react against virus-infected tolerated cells.Nature1977https://conductscience.org/library/papers/301251PubMed
8408,419Cell-mediated immune response to lymphocytic choriomeningitis and vaccinia virus in rats.J Immunol1977https://conductscience.org/library/papers/408419PubMed
9301,550The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.J Exp Med1977https://conductscience.org/library/papers/301550PubMed
1014,978,855The somatic generation of immune recognition.Eur J Immunol1971https://conductscience.org/library/papers/14978855PubMed

1 to 10 of 11

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Cited by61

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 235 citations.

PMIDTitleJournalYearIn PapersSource
42,827,948Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors.Front Immunol2026https://conductscience.org/library/papers/42827948PubMed
40,936,899Large-scale statistical mapping of T-cell receptor β sequences to human leukocyte antigens.Front Immunol2025https://conductscience.org/library/papers/40936899PubMed
28,324,142A Phase II Study of Partial and Subtotal Thymectomy for Thymoma (JART02).World J Surg2017https://conductscience.org/library/papers/28324142PubMed
28,314,856Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.J Immunol2017https://conductscience.org/library/papers/28314856PubMed
26,768,311Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.Proteomics Clin Appl2015https://conductscience.org/library/papers/26768311PubMed
25,148,022Revisiting thymic positive selection and the mature T cell repertoire for antigen.Immunity2014https://conductscience.org/library/papers/25148022PubMed
23,644,507The transcriptional landscape of αβ T cell differentiation.Nat Immunol2013https://conductscience.org/library/papers/23644507PubMed
23,290,521T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.Immunity2013https://conductscience.org/library/papers/23290521PubMed
21,302,059Host-determined T cell fine specificity for self-H-2 in radiation bone-marrow chimeras of standard C57BL/6 (H-2(b)) mutantHz1 (H-2 (ba)), and F (1) mice.Immunogenetics1978https://conductscience.org/library/papers/21302059PubMed
20,483,993Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.Proc Natl Acad Sci U S A2010https://conductscience.org/library/papers/20483993PubMed

1 to 10 of 61

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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