Paper · 307765

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

von Boehmer H and 2 others. Proc Natl Acad Sci U S A, 1978. Cited by 231 papers, by iCite.

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ConductScience Library. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. Papers, record 307765. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/307765

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1978; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/307765/; PubMed
DOI: https://doi.org/10.1073/pnas.75.5.2439; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC392569/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 231; iCite
Relative citation ratio, by iCite: 3.62; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	von Boehmer H	H
2	Haas W	W
3	Jerne NK	N K

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cytotoxicity, Immunologic	Major topic
H-2 Antigens	Major topic
Killer Cells, Natural	Major topic
Animals
Binding Sites
Cell Differentiation
Female
Genetic Linkage
Lymphocyte Cooperation
Male
Mice
Radiation Chimera
T-Lymphocytes
Thymus Gland
Y Chromosome

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	70,400	Responsiveness to HY antigen Ir gene complementation and target cell specificity.	Immunol Rev	1977	https://conductscience.org/library/papers/70400	PubMed
2	69,518	Antigen receptors of T helper cells.	Contemp Top Immunobiol	1977	https://conductscience.org/library/papers/69518	PubMed
3	69,514	Antigen-binding, idiotypic T-lymphocyte receptors.	Contemp Top Immunobiol	1977	https://conductscience.org/library/papers/69514	PubMed
4	322,367	Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.	Immunol Rev	1977	https://conductscience.org/library/papers/322367	PubMed
5	304,527	Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.	Nature	1978	https://conductscience.org/library/papers/304527	PubMed
6	305,460	The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.	J Exp Med	1978	https://conductscience.org/library/papers/305460	PubMed
7	302,210	H-2 gene complementation in cytotoxic T cell responses of female against male cells.	Eur J Immunol	1977	https://conductscience.org/library/papers/302210	PubMed
8	4,403,726	Genetics and immunology of sex-linked antigens.	Adv Immunol	1972	https://conductscience.org/library/papers/4403726	PubMed
9	59,976	Serologic and genetic aspects of murine Ia antigens.	Transplant Rev	1976	https://conductscience.org/library/papers/59976	PubMed
10	58,463	Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.	Transplant Rev	1976	https://conductscience.org/library/papers/58463	PubMed

1 to 10 of 18

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Cited by108

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 231 citations.

PMID	Title	Journal	Year	In Papers	Source
35,543,702	DCs at the center of help: Origins and evolution of the three-cell-type hypothesis.	J Exp Med	2022	https://conductscience.org/library/papers/35543702	PubMed
24,550,914	Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.	Front Immunol	2014	https://conductscience.org/library/papers/24550914	PubMed
22,457,931	Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.	Immunogenetics	1980	https://conductscience.org/library/papers/22457931	PubMed
22,457,921	T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.	Immunogenetics	1980	https://conductscience.org/library/papers/22457921	PubMed
21,302,107	Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).	Immunogenetics	1978	https://conductscience.org/library/papers/21302107	PubMed
9,696,840	CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.	J Virol	1998	https://conductscience.org/library/papers/9696840	PubMed
8,642,325	Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.	J Exp Med	1996	https://conductscience.org/library/papers/8642325	PubMed
8,062,832	A transcriptional silencer controls the developmental expression of the CD4 gene.	EMBO J	1994	https://conductscience.org/library/papers/8062832	PubMed
7,699,330	Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter.	J Exp Med	1995	https://conductscience.org/library/papers/7699330	PubMed
7,561,694	Successful T cell priming in B cell-deficient mice.	J Exp Med	1995	https://conductscience.org/library/papers/7561694	PubMed

1 to 10 of 108

See all 108 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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