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Paper · 308990

Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

Cantor H and 6 others. J Exp Med, 1978. Cited by 197 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition. Papers, record 308990. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/308990

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
197
iCite
Relative citation ratio, by iCite
3.76
iCite
Revised in PubMed
2021-12-03
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cantor HH
2Hugenberger JJ
3McVay-Boudreau LL
4Eardley DDD D
5Kemp JJ
6Shen FWF W
7Gershon RKR K

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody FormationMajor topic
Antigens, SurfaceMajor topic
Lymphocyte CooperationMajor topic
T-LymphocytesMajor topic
Animals
Feedback
Immunosuppression Therapy
Isoantigens
Mice

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References13

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1415,110Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.J Exp Med1978https://conductscience.org/library/papers/415110PubMed
2306,406Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.J Exp Med1978https://conductscience.org/library/papers/306406PubMed
3306,405Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.J Exp Med1978https://conductscience.org/library/papers/306405PubMed
4300,088Suppression of IgE antibody production in SJL mice. II. Expression of Ly-1 antigen on helper and nonspecific suppressor T cells.J Immunol1977https://conductscience.org/library/papers/300088PubMed
558,934Induction of specific suppressor T cells in vitro.J Immunol1976https://conductscience.org/library/papers/58934PubMed
61,089,726Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.J Immunol1975https://conductscience.org/library/papers/1089726PubMed
71,085,324T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.J Exp Med1976https://conductscience.org/library/papers/1085324PubMed
81,092,798Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.J Exp Med1975https://conductscience.org/library/papers/1092798PubMed
91,083,888
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.
J Exp Med1976https://conductscience.org/library/papers/1083888PubMed
101,078,834Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.J Immunol1975https://conductscience.org/library/papers/1078834PubMed

1 to 10 of 13

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Cited by61

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 197 citations.

PMIDTitleJournalYearIn PapersSource
42,259,915GPR15-guided CD8+ T regulatory cells control intestinal inflammation.Nature2026https://conductscience.org/library/papers/42259915PubMed
41,349,560CD8+ Regulatory T Cells.Annu Rev Immunol2026https://conductscience.org/library/papers/41349560PubMed
34,484,208CD8+ Regulatory T Cell - A Mystery to Be Revealed.Front Immunol2021https://conductscience.org/library/papers/34484208PubMed
32,755,620Interleukin 35 Regulatory B Cells.J Mol Biol2021https://conductscience.org/library/papers/32755620PubMed
32,421,955Advances in the Study of CD8+ Regulatory T Cells.Crit Rev Immunol2019https://conductscience.org/library/papers/32421955PubMed
31,569,411Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules.Int J Mol Sci2019https://conductscience.org/library/papers/31569411PubMed
29,757,903Contemporary Strategies and Barriers to Transplantation Tolerance.Transplantation2018https://conductscience.org/library/papers/29757903PubMed
24,151,492Interleukin 35: a key mediator of suppression and the propagation of infectious tolerance.Front Immunol2013https://conductscience.org/library/papers/24151492PubMed
23,734,666In silico investigation into dendritic cell regulation of CD8Treg mediated killing of Th1 cells in murine experimental autoimmune encephalomyelitis.BMC Bioinformatics2013https://conductscience.org/library/papers/23734666PubMed
22,491,420CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritis.J Am Soc Nephrol2012https://conductscience.org/library/papers/22491420PubMed

1 to 10 of 61

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
HLA-E3,133PubTator's text mininghttps://conductscience.org/library/genes/3133

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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