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Paper · 31367249

Distinct PD-L1/PD1 Profiles and Clinical Implications in Intrahepatic Cholangiocarcinoma Patients with Different Risk Factors.

Lu JC and 20 others. Theranostics, 2019. Cited by 71 papers, by iCite.

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ConductScience Library. Distinct PD-L1/PD1 Profiles and Clinical Implications in Intrahepatic Cholangiocarcinoma Patients with Different Risk Factors. Papers, record 31367249. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31367249

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Distinct PD-L1/PD1 Profiles and Clinical Implications in Intrahepatic Cholangiocarcinoma Patients with Different Risk Factors.
PubMed
Journal
Theranostics
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
71
iCite
Relative citation ratio, by iCite
2.41
iCite
Revised in PubMed
2020-08-25
PubMed

Authors21

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lu JCJia-Cheng
2Zeng HYHai-Ying
3Sun QMQi-Man
4Meng QNQing-Nan
5Huang XYXiao-Yong
6Zhang PFPeng-Fei
7Yang XXuan
8Peng RRui
9Gao CChao
10Wei CYChuan-Yuan

1 to 10 of 21Source PubMed

See all 21 authors

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CholangiocarcinomaMajor topic
Liver NeoplasmsMajor topic
Programmed Cell Death 1 ReceptorMajor topic
Adult
Aged
Female
Hepatitis B virus
Humans
Male
Middle Aged
Retrospective Studies
Risk Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT04634058PD-L1 Antibody Combined With CTLA-4 Antibody for Patients With Advanced Intrahepatic Cholangiocarcinoma Who Progressed After Standard TreatmentBackground

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,343,228Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions.Hepatology2001https://conductscience.org/library/papers/11343228PubMed
213,702,621Liver fluke infestation and cholangio-hepatitis.Br J Surg1961https://conductscience.org/library/papers/13702621PubMed
315,122,199Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.Nat Rev Immunol2004https://conductscience.org/library/papers/15122199PubMed
416,214,602Cholangiocarcinoma.Lancet2005https://conductscience.org/library/papers/16214602PubMed
518,500,231Inhibitory B7-family molecules in the tumour microenvironment.Nat Rev Immunol2008https://conductscience.org/library/papers/18500231PubMed
618,565,863Cancer immunology.N Engl J Med2008https://conductscience.org/library/papers/18565863PubMed
719,188,168Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma.Clin Cancer Res2009https://conductscience.org/library/papers/19188168PubMed
819,394,336Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma.Gastroenterology2009https://conductscience.org/library/papers/19394336PubMed
919,697,355Interaction of B7-H1 on intrahepatic cholangiocarcinoma cells with PD-1 on tumor-infiltrating T cells as a mechanism of immune evasion.J Surg Oncol2009https://conductscience.org/library/papers/19697355PubMed
1020,578,262CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma.Hepatology2010https://conductscience.org/library/papers/20578262PubMed

1 to 10 of 47

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Cited by55

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 71 citations.

PMIDTitleJournalYearIn PapersSource
42,400,718Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.Dig Dis Sci2026https://conductscience.org/library/papers/42400718PubMed
41,815,126Efficacy of transarterial chemoembolization combined with PD-1 versus PD-L1 inhibitors in mass-forming intrahepatic cholangiocarcinoma: a multicenter retrospective study.Transl Cancer Res2026https://conductscience.org/library/papers/41815126PubMed
41,236,411Research progress on immune checkpoint inhibitors in intrahepatic cholangiocarcinoma.Ann Med2025https://conductscience.org/library/papers/41236411PubMed
41,113,125A pathomics-integrated multimodal model to evaluate chemoimmunotherapy efficacy in unresectable intrahepatic cholangiocarcinoma.JHEP Rep2025https://conductscience.org/library/papers/41113125PubMed
41,087,028Stratifying cholangiocarcinoma: tumor microenvironment, molecular drivers, and novel immunotherapeutic approaches.Clin Mol Hepatol2026https://conductscience.org/library/papers/41087028PubMed
40,785,934Prediction of PD-L1 expression and prognosis of mass-forming intrahepatic cholangiocarcinoma based on preoperative magnetic resonance imaging.Quant Imaging Med Surg2025https://conductscience.org/library/papers/40785934PubMed
40,679,370A Scoring System for Risk Stratification in Intrahepatic Cholangiocarcinoma after Immunotherapy.Radiol Imaging Cancer2025https://conductscience.org/library/papers/40679370PubMed
40,647,383Subclassification-Specific Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Implications for Appropriate Pharmacotherapy.Cancers (Basel)2025https://conductscience.org/library/papers/40647383PubMed
40,495,091Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in intrahepatic cholangiocarcinoma carcinoma.Discov Oncol2025https://conductscience.org/library/papers/40495091PubMed
40,440,581PD-L1 Expression in Biliary Tract Cancer: Comparison Across Antibody Clones and Role as a Predictor of Response to Chemoimmunotherapy: A Meta-Analysis.JCO Precis Oncol2025https://conductscience.org/library/papers/40440581PubMed

1 to 10 of 55

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Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AFP174PubTator's text mininghttps://conductscience.org/library/genes/174NCBI Gene
CD27429,126PubTator's text mininghttps://conductscience.org/library/genes/29126NCBI Gene
CTLA41,493PubTator's text mininghttps://conductscience.org/library/genes/1493NCBI Gene
HAVCR284,868PubTator's text mininghttps://conductscience.org/library/genes/84868NCBI Gene
PDCD15,133PubTator's text mininghttps://conductscience.org/library/genes/5133NCBI Gene
TENM110,178PubTator's text mininghttps://conductscience.org/library/genes/10178NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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