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Paper · 32017145

Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.

Ahn JC and 6 others. Hepatology, 2021. Cited by 278 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma. Papers, record 32017145. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32017145

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.
PubMed
Journal
Hepatology
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
Citations, by iCite
278
iCite
Relative citation ratio, by iCite
16.2
iCite
Revised in PubMed
2022-01-19
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ahn JCJoseph C
2Teng PCPai-Chi
3Chen PJPin-Jung
4Posadas EEdwin
5Tseng HRHsian-Rong
6Lu SCShelly C
7Yang JDJu Dong

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Biomarkers, TumorMajor topic
Carcinoma, HepatocellularMajor topic
Liver NeoplasmsMajor topic
Neoplastic Cells, CirculatingMajor topic
Epithelial Cell Adhesion Molecule
Humans
Liquid Biopsy
Prognosis

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 CA172086NCI NIH HHSUnited StatesR01CA172086PubMed and NIHNIH RePORTER
R21 CA235340NCI NIH HHSUnited StatesR21CA235340PubMed and NIHNIH RePORTER
P01 CA233452NCI NIH HHSUnited StatesP01CA233452PubMed and NIHNIH RePORTER
R01 CA253651NCI NIH HHSUnited StatesR01CA253651PubMed and NIHNIH RePORTER
R01 CA246304NCI NIH HHSUnited StatesR01CA246304PubMed and NIHNIH RePORTER

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT05242237Prognostic Value of Liver Cancer CTCs Isolated by a Novel Microfluidic PlatformResults

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References94

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
129,521,467Dual-Selective and Dual-Enhanced SERS Nanoprobes Strategy for Circulating Hepatocellular Carcinoma Cells Detection.Chemistry2018https://conductscience.org/library/papers/29521467PubMed
214,999,698Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer.Hepatology2004https://conductscience.org/library/papers/14999698PubMed
321,527,564Isolation of circulating tumor cells in patients with hepatocellular carcinoma using a novel cell separation strategy.Clin Cancer Res2011https://conductscience.org/library/papers/21527564PubMed
428,883,691Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids.World J Gastroenterol2017https://conductscience.org/library/papers/28883691PubMed
527,706,479Evaluation of Patients With Hepatocellular Carcinomas That Do Not Produce α-Fetoprotein.JAMA Surg2017https://conductscience.org/library/papers/27706479PubMed
630,176,913Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA.J Exp Clin Cancer Res2018https://conductscience.org/library/papers/30176913PubMed
724,923,562Circulating biomarkers in hepatocellular carcinoma.Cancer Chemother Pharmacol2014https://conductscience.org/library/papers/24923562PubMed
827,662,377Microfluidic chip for isolation of viable circulating tumor cells of hepatocellular carcinoma for their culture and drug sensitivity assay.Cancer Biol Ther2016https://conductscience.org/library/papers/27662377PubMed
925,171,411Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.Cell2014https://conductscience.org/library/papers/25171411PubMed
1025,984,697A microfluidic device for label-free, physical capture of circulating tumor cell clusters.Nat Methods2015https://conductscience.org/library/papers/25984697PubMed

1 to 10 of 94

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Cited by213

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 278 citations.

PMIDTitleJournalYearIn PapersSource
42,958,405Deep N-glycoproteomic profiling of FFPE tissues enables precise diagnosis of primary liver cancer from metastatic liver cancer.J Transl Med2026https://conductscience.org/library/papers/42958405PubMed
42,947,149CTC-AttnNet: development and validation of an attention-based neural network for staging gastrointestinal malignancies.World J Surg Oncol2026https://conductscience.org/library/papers/42947149PubMed
42,909,923Portal Vein Tumor Thrombus in Hepatocellular Carcinoma: An Immune Sanctuary Driving Immune Exclusion and Therapeutic Resistance.Liver Cancer2026https://conductscience.org/library/papers/42909923PubMed
42,884,598Preoperative Zinc Deficiency as a Novel Prognostic Predictor for Postoperative Recurrence in Hepatocellular Carcinoma.Nutrients2026https://conductscience.org/library/papers/42884598PubMed
42,602,972A CTC/DTC-centered temporal framework of bone metastasis: From dissemination to dormancy and reactivation.J Bone Oncol2026https://conductscience.org/library/papers/42602972PubMed
42,591,545HOXD9 prioritization within developmental regulator-related genes suggests stage-adjusted prognostic relevance in hepatocellular carcinoma.Transl Cancer Res2026https://conductscience.org/library/papers/42591545PubMed
42,552,362AKR1B10 as a serum marker for diagnosis and postoperative monitoring of hepatocellular carcinoma.Br J Cancer2026https://conductscience.org/library/papers/42552362PubMed
42,445,440The evolving landscape of early diagnosis for hepatocellular carcinoma: a bibliometric analysis of global research trends (2016-2026) based on WoSCC database.Transl Cancer Res2026https://conductscience.org/library/papers/42445440PubMed
42,437,748Tumor heterogeneity: development, mechanisms, and therapeutic implications.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42437748PubMed
42,394,181Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications.ChemistryOpen2026https://conductscience.org/library/papers/42394181PubMed

1 to 10 of 213

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Genes39

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACE1,636PubTator's text mininghttps://conductscience.org/library/genes/1636NCBI Gene
AFP174PubTator's text mininghttps://conductscience.org/library/genes/174NCBI Gene
AHSG197PubTator's text mininghttps://conductscience.org/library/genes/197NCBI Gene
AKT2208PubTator's text mininghttps://conductscience.org/library/genes/208NCBI Gene
ALB213PubTator's text mininghttps://conductscience.org/library/genes/213NCBI Gene
ANXA2302PubTator's text mininghttps://conductscience.org/library/genes/302NCBI Gene
APOH350PubTator's text mininghttps://conductscience.org/library/genes/350NCBI Gene
ASGR1432PubTator's text mininghttps://conductscience.org/library/genes/432NCBI Gene
BCAT1586PubTator's text mininghttps://conductscience.org/library/genes/586NCBI Gene
CD27429,126PubTator's text mininghttps://conductscience.org/library/genes/29126NCBI Gene

1 to 10 of 39

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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