Paper · 32668122

Etiologic Index - A Case-Only Measure of BRCA1/2-Associated Cancer Risk.

Hughley R and 5 others. N Engl J Med, 2020. Cited by 21 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Etiologic Index - A Case-Only Measure of BRCA1/2-Associated Cancer Risk. Papers, record 32668122. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32668122

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Etiologic Index - A Case-Only Measure of BRCA1/2-Associated Cancer Risk.; PubMed
Journal: N Engl J Med; PubMed
Year: 2020; PubMed
Publication types: Letter, Comment; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/32668122/; PubMed
DOI: https://doi.org/10.1056/nejmc1913988; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7546370/; PubMed
The journal: https://conductscience.org/library/journal-index/0255562; PubMed
Citations, by iCite: 21; iCite
Relative citation ratio, by iCite: 0.64; iCite
Revised in PubMed: 2025-05-30; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Hughley R	Raymond
2	Karlic R	Rosa
3	Joshi H	Himanshu	https://orcid.org/0000-0003-0272-0733
4	Turnbull C	Clare
5	Foulkes WD	William D	https://orcid.org/0000-0001-7427-4651
6	Polak P	Paz	https://orcid.org/0000-0002-2153-4488

Source PubMed

Topics4

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Neoplasms	Major topic
BRCA1 Protein
Humans
Phenotype

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R35CA220491-03S1	NIH HHS	United States	R35CA220491	PubMed and NIH	NIH RePORTER
R35 CA220491	NCI NIH HHS	United States	R35CA220491	PubMed and NIH	NIH RePORTER
P30 CA196521-01	NCI NIH HHS	United States	P30CA196521	PubMed and NIH	NIH RePORTER
FDN-148390	CIHR	Canada		PubMed	PubMed
27223	Cancer Research UK	United Kingdom		PubMed	PubMed
P30 CA196521	NCI NIH HHS	United States	P30CA196521	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment on	31,292,550	Tumour lineage shapes BRCA-mediated phenotypes.	https://conductscience.org/library/papers/31292550

Source PubMed

References5

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	31,292,550	Tumour lineage shapes BRCA-mediated phenotypes.	Nature	2019	https://conductscience.org/library/papers/31292550	PubMed
2	10,433,620	Cancer risks in BRCA2 mutation carriers.	J Natl Cancer Inst	1999	https://conductscience.org/library/papers/10433620	PubMed
3	28,825,726	A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.	Nat Genet	2017	https://conductscience.org/library/papers/28825726	PubMed
4	12,237,281	Cancer Incidence in BRCA1 mutation carriers.	J Natl Cancer Inst	2002	https://conductscience.org/library/papers/12237281	PubMed
5	30,646,163	Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants.	JAMA Netw Open	2018	https://conductscience.org/library/papers/30646163	PubMed

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 21 citations.

PMID	Title	Journal	Year	In Papers	Source
41,951,763	A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair-deficient breast or ovarian cancer.	BJC Rep	2026	https://conductscience.org/library/papers/41951763	PubMed
40,866,199	APC I1307K and clinical management: insights from UK Biobank association analysis of colorectal and other cancer risks in Ashkenazi and non-Ashkenazi whites.	J Med Genet	2025	https://conductscience.org/library/papers/40866199	PubMed
40,252,048	Transforming treatment paradigms: Focus on personalized medicine for high-grade serous ovarian cancer.	CA Cancer J Clin	2025	https://conductscience.org/library/papers/40252048	PubMed
39,585,318	Childhood, adolescent, and young adulthood cancer risk in BRCA1 or BRCA2 pathogenic variant carriers.	J Natl Cancer Inst	2025	https://conductscience.org/library/papers/39585318	PubMed
38,960,732	Genomic instability in non-breast or ovarian malignancies of individuals with germline pathogenic variants in BRCA1/2.	J Natl Cancer Inst	2024	https://conductscience.org/library/papers/38960732	PubMed
38,886,216	BRCA1 and friends 30 years on.	Nat Rev Genet	2024	https://conductscience.org/library/papers/38886216	PubMed
34,778,690	Differential Activity of PARP Inhibitors in BRCA1- Versus BRCA2-Altered Metastatic Castration-Resistant Prostate Cancer.	JCO Precis Oncol	2021	https://conductscience.org/library/papers/34778690	PubMed
34,240,211	Li-Fraumeni Syndrome in the Cancer Genomics Era.	J Natl Cancer Inst	2021	https://conductscience.org/library/papers/34240211	PubMed
34,240,179	Paired Tumor-Normal Sequencing Provides Insights Into the TP53-Related Cancer Spectrum in Patients With Li-Fraumeni Syndrome.	J Natl Cancer Inst	2021	https://conductscience.org/library/papers/34240179	PubMed
33,710,348	Endometrial Cancer Risk in Women With Germline BRCA1 or BRCA2 Mutations: Multicenter Cohort Study.	J Natl Cancer Inst	2021	https://conductscience.org/library/papers/33710348	PubMed

1 to 10 of 13

See all 13 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
BRCA1	672	PubTator's text mining	https://conductscience.org/library/genes/672	NCBI Gene
BRCA2	675	PubTator's text mining	https://conductscience.org/library/genes/675	NCBI Gene
GP9	2,815	PubTator's text mining	https://conductscience.org/library/genes/2815	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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