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Paper · 31292550

Tumour lineage shapes BRCA-mediated phenotypes.

Jonsson P and 30 others. Nature, 2019. Cited by 347 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Tumour lineage shapes BRCA-mediated phenotypes. Papers, record 31292550. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31292550

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Tumour lineage shapes BRCA-mediated phenotypes.
PubMed
Journal
Nature
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
347
iCite
Relative citation ratio, by iCite
10.4
iCite
Revised in PubMed
2026-11-02
PubMed

Authors31

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Jonsson PPhilip
2Bandlamudi CChaitanya
3Cheng MLMichael L
4Srinivasan PPreethi
5Chavan SSShweta S
6Friedman NDNoah D
7Rosen EYEzra Y
8Richards ALAllison L
9Bouvier NNancy
10Selcuklu SDS Duygu

1 to 10 of 31Source PubMed

See all 31 authors

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell LineageMajor topic
Genes, BRCA1Major topic
Genes, BRCA2Major topic
MutationMajor topic
NeoplasmsMajor topic
PhenotypeMajor topic
Alleles
Cohort Studies
Heterozygote
Humans
Poly(ADP-ribose) Polymerase Inhibitors
Zygote

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 CA207244NCI NIH HHSUnited StatesR01CA207244PubMed and NIHNIH RePORTER
R01 CA227534NCI NIH HHSUnited StatesR01CA227534PubMed and NIHNIH RePORTER
P50 CA092629NCI NIH HHSUnited StatesP50CA092629PubMed and NIHNIH RePORTER
R25 CA233208NCI NIH HHSUnited StatesR25CA233208PubMedNIH RePORTER
P30 CA008748NCI NIH HHSUnited StatesP30CA008748PubMed and NIHNIH RePORTER
P50 CA221745NCI NIH HHSUnited StatesP50CA221745PubMedNIH RePORTER
R01 CA204749NCI NIH HHSUnited StatesR01CA204749PubMed and NIHNIH RePORTER
U54OD020355NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections5

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Erratum in31,822,847Author Correction: Tumour lineage shapes BRCA-mediated phenotypes.https://conductscience.org/library/papers/31822847PubMed
Comment in31,582,817Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy.https://conductscience.org/library/papers/31582817PubMed
Comment in31,610,093Melanoma predisposition-A limited role for germline BRCA1 and BRCA2 variants.https://conductscience.org/library/papers/31610093PubMed
Comment in32,668,122Etiologic Index - A Case-Only Measure of BRCA1/2-Associated Cancer Risk.https://conductscience.org/library/papers/32668122PubMed
Comment in33,772,500Heterozygous PALB2 Mutation in a Boy with Acute Lymphoblastic Leukemia and Subsequent Metastatic Ewing Sarcoma.https://conductscience.org/library/papers/33772500PubMed

References44

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,524,414Identification of the breast cancer susceptibility gene BRCA2.Nature1995https://conductscience.org/library/papers/8524414PubMed
27,545,954A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.Science1994https://conductscience.org/library/papers/7545954PubMed
322,193,408BRCA1 and BRCA2: different roles in a common pathway of genome protection.Nat Rev Cancer2011https://conductscience.org/library/papers/22193408PubMed
427,664,246Prevention and screening in BRCA mutation carriers and other breast/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention and screening.Ann Oncol2016https://conductscience.org/library/papers/27664246PubMed
528,831,036BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers.Nat Commun2017https://conductscience.org/library/papers/28831036PubMed
626,775,620BRCAness revisited.Nat Rev Cancer2016https://conductscience.org/library/papers/26775620PubMed
710,837,032Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.Genes Dev2000https://conductscience.org/library/papers/10837032PubMed
811,239,455BRCA2 is required for homology-directed repair of chromosomal breaks.Mol Cell2001https://conductscience.org/library/papers/11239455PubMed
910,549,283Brca1 controls homology-directed DNA repair.Mol Cell1999https://conductscience.org/library/papers/10549283PubMed
1023,945,592Signatures of mutational processes in human cancer.Nature2013https://conductscience.org/library/papers/23945592PubMed

1 to 10 of 44

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Cited by258

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 347 citations.

PMIDTitleJournalYearIn PapersSource
42,598,072Interpreting homologous recombination deficiency in rare gynecological cancers: A case of primary mucinous endometrial adenocarcinoma of gastrointestinal type.Gynecol Oncol Rep2026https://conductscience.org/library/papers/42598072PubMed
42,521,810Bridging the gap: integrating hereditary cancer into precision oncology.Eur J Hum Genet2026https://conductscience.org/library/papers/42521810PubMed
42,498,744Chinese expert consensus on precision testing and molecular diagnosis of pancreatic cancer (2025).Br J Cancer2026https://conductscience.org/library/papers/42498744PubMed
42,308,463Phase II Study of Adavosertib in Patients With Tumors Containing BRCA1 and BRCA2 Mutations: Results From the NCI-MATCH ECOG-ACRIN Cancer Research Group (EAY131) Subprotocol Z1I.JCO Precis Oncol2026https://conductscience.org/library/papers/42308463PubMed
42,186,016Whole genome sequencing in oesophageal adenocarcinoma unmasks potential precision therapies.BMC Cancer2026https://conductscience.org/library/papers/42186016PubMed
42,132,987Why are Some Tissues More Vulnerable? Revisiting Tissue Specificity in Hereditary Cancer Syndromes.Mol Diagn Ther2026https://conductscience.org/library/papers/42132987PubMed
41,998,785Estrogen receptor-positive, BRCA1-deficient breast cancer: BRCA1-epimutated tumors presenting a piece to the puzzle.Breast Cancer Res2026https://conductscience.org/library/papers/41998785PubMed
41,990,295Germline Pathogenic Variants in Homologous Recombination Pathway Genes Are Frequent in Pancreatobiliary Ampullary Carcinoma.JCO Precis Oncol2026https://conductscience.org/library/papers/41990295PubMed
41,895,280Cancer type-specific variation in patterns of driver alterations across 50,000 tumors.Cancer Cell2026https://conductscience.org/library/papers/41895280PubMed
41,867,230Cancer genomic profiling predicts pathogenicity of BRCA1 and BRCA2 variants.medRxiv2026https://conductscience.org/library/papers/41867230PubMed

1 to 10 of 258

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Genes28

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
BARD1580PubTator's text mininghttps://conductscience.org/library/genes/580NCBI Gene
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
BRIP183,990PubTator's text mininghttps://conductscience.org/library/genes/83990NCBI Gene
CD27429,126PubTator's text mininghttps://conductscience.org/library/genes/29126NCBI Gene
CHEK11,111PubTator's text mininghttps://conductscience.org/library/genes/1111NCBI Gene
CHEK211,200PubTator's text mininghttps://conductscience.org/library/genes/11200NCBI Gene
CTLA41,493PubTator's text mininghttps://conductscience.org/library/genes/1493NCBI Gene
FANCA2,175PubTator's text mininghttps://conductscience.org/library/genes/2175NCBI Gene

1 to 10 of 28

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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