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Paper · 7545954

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Miki Y and 9 others. Science, 1994. Cited by 5,107 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Papers, record 7545954. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7545954

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
PubMed
Journal
Science
PubMed
Year
1994
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
5,107
iCite
Relative citation ratio, by iCite
113
iCite
Revised in PubMed
2022-04-08
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Miki YY
2Swensen JJ
3Shattuck-Eidens DD
4Futreal PAP A
5Harshman KK
6Tavtigian SS
7Liu QQ
8Cochran CC
9Bennett LML M
10Ding WW

Source PubMed

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Breast NeoplasmsMajor topic
Chromosomes, Human, Pair 17Major topic
Genes, Tumor SuppressorMajor topic
MutationMajor topic
Neoplasm ProteinsMajor topic
Ovarian NeoplasmsMajor topic
Transcription FactorsMajor topic
Alleles
Alternative Splicing
Amino Acid Sequence
Animals
BRCA1 Protein
Female
Genetic Predisposition to Disease
Germ-Line Mutation
Haplotypes
Humans
Lod Score
Male
Molecular Sequence Data
Pedigree
Phenotype
Zinc Fingers

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
CA-48711NCI NIH HHSUnited StatesP01CA048711PubMed and NIHNIH RePORTER
CA-54936NCI NIH HHSUnited StatesR03CA054936PubMed and NIHNIH RePORTER
CA-55914NCI NIH HHSUnited StatesR01CA055914PubMed and NIHNIH RePORTER

Trials3

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT00001496Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast CancerBackgroundClinicalTrials.gov
NCT02783664Evaluating the Effects of Genetic Testing on Patients' Stress LevelsBackgroundClinicalTrials.gov
NCT03667417Genetic Predisposition to Breast and Ovarian Cancer: Prospective Study of BRCAx Gene MutationBackgroundClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by1,952

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 5,107 citations.

PMIDTitleJournalYearIn PapersSource
42,856,358PWK genetic background reprograms heterochromatin and malignant epithelial states in Neu-driven mammary tumors.bioRxiv2026https://conductscience.org/library/papers/42856358PubMed
42,800,850Microbial production of eumelanin from a desert-derived Aspergillus terreus: statistical optimization, comprehensive characterization, and in silico insights into breast cancer-associated targets.Microb Cell Fact2026https://conductscience.org/library/papers/42800850PubMed
42,741,651Overcoming Resistance to PARP Inhibitors in BRCA-Mutated Cancers: Mechanisms and Therapeutic Strategies.J Cancer2026https://conductscience.org/library/papers/42741651PubMed
42,706,393Editorial on the hereditary cancer special issue.Eur J Hum Genet2026https://conductscience.org/library/papers/42706393PubMed
42,693,354The 1H, 15N and 13C backbone resonance assignments of an intrinsically disordered region (467-696) of breast cancer type 1 susceptibility protein (BRCA1).Biomol NMR Assign2026https://conductscience.org/library/papers/42693354PubMed
42,676,320[BRCA1 Gene's Mutations And Hereditary Breast Cancer: Genetic, Biological, And Clinical Aspects].Mali Med2025https://conductscience.org/library/papers/42676320PubMed
42,667,452The evolution of hereditary cancer genetic counselling: mainstreaming, service redesign and patient experience in Lynch syndrome.Fam Cancer2026https://conductscience.org/library/papers/42667452PubMed
42,647,128Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals.Proc Natl Acad Sci U S A2026https://conductscience.org/library/papers/42647128PubMed
42,643,219Fear of cancer occurrence in breast cancer previvors: a scoping review of the literature.Front Psychol2026https://conductscience.org/library/papers/42643219PubMed
42,635,688RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42635688PubMed

1 to 10 of 1,952

See all 1,952 cited by

Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BRCA1672Swiss-Prot's referenceshttps://conductscience.org/library/genes/672NCBI Gene
PSME310,197Swiss-Prot's referenceshttps://conductscience.org/library/genes/10197NCBI Gene
AARSD180,755PubTator's text mininghttps://conductscience.org/library/genes/80755NCBI Gene
ARL4D379PubTator's text mininghttps://conductscience.org/library/genes/379NCBI Gene
NBR14,077PubTator's text mininghttps://conductscience.org/library/genes/4077NCBI Gene
NCF1653,361PubTator's text mininghttps://conductscience.org/library/genes/653361NCBI Gene
PTGES3L-AARSD1100,885,850PubTator's text mininghttps://conductscience.org/library/genes/100885850NCBI Gene
RPL276,155PubTator's text mininghttps://conductscience.org/library/genes/6155NCBI Gene
VAT110,493PubTator's text mininghttps://conductscience.org/library/genes/10493NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data30

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
GENBANKU14680GENBANK
GENBANKU15595GENBANK
GENBANKU25750GENBANK
GENBANKU25751GENBANK
GENBANKU25752GENBANK
GENBANKU25753GENBANK
GENBANKU25754GENBANK
GENBANKU25755GENBANK
GENBANKU25756GENBANK
GENBANKU25757GENBANK

1 to 10 of 30

See all 30 data

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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