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Paper · 23945592

Signatures of mutational processes in human cancer.

Alexandrov LB and 74 others. Nature, 2013. Cited by 7,815 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Signatures of mutational processes in human cancer. Papers, record 23945592. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23945592

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Signatures of mutational processes in human cancer.
PubMed
Journal
Nature
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
7,815
iCite
Relative citation ratio, by iCite
214
iCite
Revised in PubMed
2026-05-18
PubMed

Authors75

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Alexandrov LBLudmil B
2Nik-Zainal SSerena
3Wedge DCDavid C
4Aparicio SASamuel A J R
5Behjati SSam
6Biankin AVAndrew V
7Bignell GRGraham R
8Bolli NNiccolò
9Borg AAke
10Børresen-Dale ALAnne-Lise

1 to 10 of 75Source PubMed

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Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell Transformation, NeoplasticMajor topic
MutagenesisMajor topic
MutationMajor topic
NeoplasmsMajor topic
Aging
Algorithms
Cytidine Deaminase
DNA
DNA Mutational Analysis
Humans
Models, Genetic
Mutagenesis, Insertional
Mutagens
Organ Specificity
Reproducibility of Results
Sequence Deletion
Transcription, Genetic

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
088340Wellcome TrustUnited KingdomPubMedPubMed
093867Wellcome TrustUnited KingdomPubMedPubMed
T32 CA009216NCI NIH HHSUnited StatesT32CA009216PubMed and NIHNIH RePORTER
098051Wellcome TrustUnited KingdomPubMedPubMed

Trials12

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT02869802Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic AnalysisBackgroundClinicalTrials.gov
NCT03044613Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal CancerBackgroundClinicalTrials.gov
NCT03835533Platform Study for Prostate Researching Translational Endpoints Correlated to Response to Inform Use of Novel CombinationsBackgroundClinicalTrials.gov
NCT04033965Corellation of Mutations, TILs and Age in Breast CancerBackgroundClinicalTrials.gov
NCT04197219Pembrolizumab With Axitinib in Recurrent Endometrial CancerBackgroundClinicalTrials.gov
NCT04441138Chemoradiation Followed by Durvalumab in Poor Risk and/or Elderly Patients With Stage III NSCLCBackgroundClinicalTrials.gov
NCT04696848The Efficacy and Safety of CKD516 Combined With Durvalumab in Patient Refractory Solid TumorsBackgroundClinicalTrials.gov
NCT04765709Durvalumab and Chemotherapy Induction Followed by Durvalumab and Radiotherapy in Large Volume Stage III NSCLCBackgroundClinicalTrials.gov
NCT05092412Low-dose Radiotherapy Combined With Durvalumab, Chemotherapy(EP) in the Treatment of ES-SCLCBackgroundClinicalTrials.gov
NCT05568212Randomized Trial Comparing Standard of Care Versus Immune- Based Combination in Relapsed Stage III Non-small-cell Lung Cancer (NSCLC) Pretreated With Chemoradiotherapy and DurvalumabBackgroundClinicalTrials.gov

1 to 10 of 12

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Comments and corrections3

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in23,982,625Cancer genomics: Signature analysis suggests cancer origins.https://conductscience.org/library/papers/23982625PubMed
Comment in23,999,215Genetics: Signatures of mutational processes in cancer-a big step closer.https://conductscience.org/library/papers/23999215PubMed
Comment in24,060,860Genomics: Mutator catalogues.https://conductscience.org/library/papers/24060860PubMed

References64

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
123,128,226An integrated map of genetic variation from 1,092 human genomes.Nature2012https://conductscience.org/library/papers/23128226PubMed
222,895,193Recurrent R-spondin fusions in colon cancer.Nature2012https://conductscience.org/library/papers/22895193PubMed
321,798,893The mutational landscape of head and neck squamous cell carcinoma.Science2011https://conductscience.org/library/papers/21798893PubMed
423,202,128Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.Nat Genet2013https://conductscience.org/library/papers/23202128PubMed
522,484,628Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.Nat Genet2012https://conductscience.org/library/papers/22484628PubMed
618,948,947Somatic mutations affect key pathways in lung adenocarcinoma.Nature2008https://conductscience.org/library/papers/18948947PubMed
723,263,491Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.Nat Genet2013https://conductscience.org/library/papers/23263491PubMed
823,334,668The genomic landscape of hypodiploid acute lymphoblastic leukemia.Nat Genet2013https://conductscience.org/library/papers/23334668PubMed
920,707,934Environmental exposures and mutational patterns of cancer genomes.Genome Med2010https://conductscience.org/library/papers/20707934PubMed
1022,683,710BAP1 loss defines a new class of renal cell carcinoma.Nat Genet2012https://conductscience.org/library/papers/22683710PubMed

1 to 10 of 64

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Cited by5,838

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 7,815 citations.

PMIDTitleJournalYearIn PapersSource
42,989,104MutFormer: a multimodal deep learning framework for predicting somatic mutation hotspots from sequence and chromatin features.BMC Genomics2026https://conductscience.org/library/papers/42989104PubMed
42,988,826Integrated genomic and transcriptomic profiling across the clinical spectrum of Lynch syndrome-associated endometrial disease.NPJ Precis Oncol2026https://conductscience.org/library/papers/42988826PubMed
42,971,966RFWD3/FANCW orchestrates post-replicative filling of ssDNA gaps to promote UV tolerance.Nat Commun2026https://conductscience.org/library/papers/42971966PubMed
42,957,698PrimPol toggled by ATR modulates fork slowing and repriming under oncogenic KRAS-induced replication stress.Nat Commun2026https://conductscience.org/library/papers/42957698PubMed
42,953,000Extrachromosomal circular DNA drives focal amplification of AGAP2-AS1 to promote cutaneous tumorigenesis.Front Pharmacol2026https://conductscience.org/library/papers/42953000PubMed
42,950,362Integrated genomic and transcriptomic profiling reveals distinct molecular features of colorectal cancer in an Indian cohort.Neoplasia2026https://conductscience.org/library/papers/42950362PubMed
42,948,523The immunogenicity control axis: a multi-omics framework for integrating epigenetic, DNA damage response, and immune states in cancer.Front Genet2026https://conductscience.org/library/papers/42948523PubMed
42,931,977NRAS Mutations in Different Melanoma Histotypes: Molecular and Clinical Implications.Curr Oncol Rep2026https://conductscience.org/library/papers/42931977PubMed
42,920,328Assessing the Mutational Consequences of Chronic Arsenic Exposure Using Patient-Derived Tumor Samples and In Vitro Systems.Environ Mol Mutagen2026https://conductscience.org/library/papers/42920328PubMed
42,911,976Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns based upon clinico-genomic status.PLoS Genet2026https://conductscience.org/library/papers/42911976PubMed

1 to 10 of 5,838

See all 5,838 cited by

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AICDA57,379PubTator's text mininghttps://conductscience.org/library/genes/57379NCBI Gene
APOBEC1339PubTator's text mininghttps://conductscience.org/library/genes/339NCBI Gene
APOBEC3A200,315PubTator's text mininghttps://conductscience.org/library/genes/200315NCBI Gene
APOBEC3B9,582PubTator's text mininghttps://conductscience.org/library/genes/9582NCBI Gene
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
CCDC68,030PubTator's text mininghttps://conductscience.org/library/genes/8030NCBI Gene
CDA978PubTator's text mininghttps://conductscience.org/library/genes/978NCBI Gene
IGHV3-69-128,402PubTator's text mininghttps://conductscience.org/library/genes/28402NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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