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Paper · 33859400

Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.

Keating SM and 47 others. Nat Biotechnol, 2021. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Generation of recombinant hyperimmune globulins from diverse B-cell repertoires. Papers, record 33859400. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33859400

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.
PubMed
Journal
Nat Biotechnol
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
23
iCite
Relative citation ratio, by iCite
1.15
iCite
Revised in PubMed
2026-11-02
PubMed

Authors48

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Keating SMSheila Mhttps://orcid.org/0000-0002-8324-3694
2Mizrahi RARena Ahttps://orcid.org/0000-0001-8581-2240
3Adams MSMatthew S
4Asensio MAMichael Ahttps://orcid.org/0000-0001-9087-0568
5Benzie EEmily
6Carter KPKyle P
7Chiang YYao
8Edgar RCRobert C
9Gautam BKBishal Khttps://orcid.org/0000-0001-7261-8406
10Gras AAshley

1 to 10 of 48Source PubMed

See all 48 authors

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
COVID-19Major topic
GlobulinsMajor topic
SARS-CoV-2Major topic
Animals
Antibodies, Viral
CHO Cells
Cricetulus
Enzyme-Linked Immunosorbent Assay
Humans
Immunization, Passive
Mice
Recombinant Proteins
Zika Virus
COVID-19 Serotherapy

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R44 AI115892NIAID NIH HHSUnited StatesR44AI115892PubMed and NIHNIH RePORTER
R44 AI124901NIAID NIH HHSUnited StatesR44AI124901PubMed and NIHNIH RePORTER
R44AI124901U.S. Department of Health & Human Services | National Institutes of Health (NIH)R44AI124901PubMed and NIHNIH RePORTER
1230150National Science Foundation (NSF)PubMedPubMed
R44AI115892U.S. Department of Health & Human Services | National Institutes of Health (NIH)R44AI115892PubMed and NIHNIH RePORTER

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT04883138Recombinant Hyperimmune Polyclonal Antibody (GIGA-2050) in COVID-19 PatientsBackground

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,480,779Use of human immunoglobulins as an anti-infective treatment: the experience so far and their possible re-emerging role.Expert Rev Anti Infect Ther2017https://conductscience.org/library/papers/28480779PubMed
26,339,349Efficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B virus carrier state: final report of a randomized double-blind, placebo-controlled trial.Hepatology1983https://conductscience.org/library/papers/6339349PubMed
329,229,452Efficacy of Human Botulism Immune Globulin for the Treatment of Infant Botulism: The First 12 Years Post Licensure.J Pediatr2018https://conductscience.org/library/papers/29229452PubMed
49,679,818Results of the double-blind, randomized, multicenter, phase III clinical trial of Thymoglobulin versus Atgam in the treatment of acute graft rejection episodes after renal transplantation.Transplantation1998https://conductscience.org/library/papers/9679818PubMed
531,285,451Human Polyclonal Antibodies Prevent Lethal Zika Virus Infection in Mice.Sci Rep2019https://conductscience.org/library/papers/31285451PubMed
632,254,064Deployment of convalescent plasma for the prevention and treatment of COVID-19.J Clin Invest2020https://conductscience.org/library/papers/32254064PubMed
732,219,428Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma.JAMA2020https://conductscience.org/library/papers/32219428PubMed
812,556,024Responding to the immunoglobulin shortage: a case study.J Health Polit Policy Law2002https://conductscience.org/library/papers/12556024PubMed
97,526,215Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin.N Engl J Med1994https://conductscience.org/library/papers/7526215PubMed
1021,545,600Identification of kallikrein and FXIa as impurities in therapeutic immunoglobulins: implications for the safety and control of intravenous blood products.Vox Sang2012https://conductscience.org/library/papers/21545600PubMed

1 to 10 of 46

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Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMIDTitleJournalYearIn PapersSource
42,909,796Base editing-mediated exon-specific knockout of glutamine synthetase generates a high-productivity CHO cell line for antibody manufacturing.Bioresour Bioprocess2026https://conductscience.org/library/papers/42909796PubMed
42,003,948Sterility, safety, and preventive efficacy of three polyvalent hyperimmune sera against bacterial infection in a white mouse challenge model.Front Vet Sci2026https://conductscience.org/library/papers/42003948PubMed
39,689,695High-throughput specificity profiling of antibody libraries using ribosome display and microfluidics.Cell Rep Methods2024https://conductscience.org/library/papers/39689695PubMed
39,380,504Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies.Biotechnol J2024https://conductscience.org/library/papers/39380504PubMed
39,366,976Developing a workflow for the isolation of hybridoma cells producing fully human antigen-specific antibodies using a surface IgG detection method.Sci Rep2024https://conductscience.org/library/papers/39366976PubMed
39,240,970Fluorescence-activated droplet sequencing (FAD-seq) directly provides sequences of screening hits in antibody discovery.Proc Natl Acad Sci U S A2024https://conductscience.org/library/papers/39240970PubMed
39,055,704Charting a course for global progress in PIDs by 2030 - proceedings from the IPOPI global multi-stakeholders' summit (September 2023).Front Immunol2024https://conductscience.org/library/papers/39055704PubMed
38,877,201Hyperimmune Globulins in COVID-19.Curr Top Microbiol Immunol2025https://conductscience.org/library/papers/38877201PubMed
37,324,547Rapid engineering of SARS-CoV-2 therapeutic antibodies to increase breadth of neutralization including BQ.1.1, CA.3.1, CH.1.1, XBB.1.16, and XBB.1.5.Antib Ther2023https://conductscience.org/library/papers/37324547PubMed
37,243,248False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies.Viruses2023https://conductscience.org/library/papers/37243248PubMed

1 to 10 of 18

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Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACE259,272PubTator's text mininghttps://conductscience.org/library/genes/59272NCBI Gene
CD79A973PubTator's text mininghttps://conductscience.org/library/genes/973NCBI Gene
IGK50,802PubTator's text mininghttps://conductscience.org/library/genes/50802NCBI Gene
MYC4,609PubTator's text mininghttps://conductscience.org/library/genes/4609NCBI Gene
PTPRC5,788PubTator's text mininghttps://conductscience.org/library/genes/5788NCBI Gene
RHO6,010PubTator's text mininghttps://conductscience.org/library/genes/6010NCBI Gene
TRBV20OR9-26,962PubTator's text mininghttps://conductscience.org/library/genes/6962NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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