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Paper · 34584171

Common and disorder-specific upregulation of the inflammatory markers TRAIL and CCL20 in depression and schizophrenia.

Klaus F and 6 others. Sci Rep, 2021. Cited by 12 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Common and disorder-specific upregulation of the inflammatory markers TRAIL and CCL20 in depression and schizophrenia. Papers, record 34584171. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34584171

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Common and disorder-specific upregulation of the inflammatory markers TRAIL and CCL20 in depression and schizophrenia.
PubMed
Journal
Sci Rep
PubMed
Year
2021
PubMed
Publication types
Journal Article, Observational Study, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
12
iCite
Relative citation ratio, by iCite
0.86
iCite
Revised in PubMed
2026-01-27
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Klaus FFederica
2Guetter KKaroline
3Schlegel RRebecca
4Spiller TRTobias R
5Seifritz EErich
6Cathomas FFlurin
7Kaiser SStefan

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Chemokine CCL20Major topic
Major Depressive DisorderMajor topic
SchizophreniaMajor topic
TNF-Related Apoptosis-Inducing LigandMajor topic
Adult
Biomarkers
Case-Control Studies
Female
Healthy Volunteers
Humans
Male
Middle Aged
Up-Regulation
Young Adult

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References69

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,749,891Serum and gene expression profile of cytokines in first-episode psychosis.Brain Behav Immun2013https://conductscience.org/library/papers/22749891PubMed
229,928,963Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis.Brain Behav Immun2018https://conductscience.org/library/papers/29928963PubMed
327,028,512Genetic Evaluation of Schizophrenia Using the Illumina HumanExome Chip.PLoS One2016https://conductscience.org/library/papers/27028512PubMed
430,190,688C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review.Front Psychiatry2018https://conductscience.org/library/papers/30190688PubMed
526,910,728Clinical perspectives of TRAIL: insights into central nervous system disorders.Cell Mol Life Sci2016https://conductscience.org/library/papers/26910728PubMed
620,015,486A meta-analysis of cytokines in major depression.Biol Psychiatry2010https://conductscience.org/library/papers/20015486PubMed
730,766,494Constructing the Immune Signature of Schizophrenia for Clinical Use and Research; An Integrative Review Translating Descriptives Into Diagnostics.Front Psychiatry2018https://conductscience.org/library/papers/30766494PubMed
818,073,775From inflammation to sickness and depression: when the immune system subjugates the brain.Nat Rev Neurosci2008https://conductscience.org/library/papers/18073775PubMed
915,908,096Apoptotic mechanisms in the pathophysiology of schizophrenia.Prog Neuropsychopharmacol Biol Psychiatry2005https://conductscience.org/library/papers/15908096PubMed
1021,334,376Immune system to brain signaling: neuropsychopharmacological implications.Pharmacol Ther2011https://conductscience.org/library/papers/21334376PubMed

1 to 10 of 69

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Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 12 citations.

PMIDTitleJournalYearIn PapersSource
42,249,349Serum IL-17A and CCL20 levels and their correlation with obsessive-compulsive disorder and suicidality in schizophrenia and bipolar mood disorder.BMC Psychiatry2026https://conductscience.org/library/papers/42249349PubMed
41,200,225Th17-related cytokines and chemokines are associated with immune dysregulation and severity in schizophrenia.Front Psychiatry2025https://conductscience.org/library/papers/41200225PubMed
40,926,657Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.Psychol Med2025https://conductscience.org/library/papers/40926657PubMed
40,646,788Genetic Parameters, Linear Associations, and Genome-Wide Association Study for Endotoxin-Induced Cortisol Response in Holstein heifers.Animals (Basel)2025https://conductscience.org/library/papers/40646788PubMed
39,799,156Associations between biomarkers of inflammation and depressive symptoms-potential differences between diabetes types and symptom clusters of depression.Transl Psychiatry2025https://conductscience.org/library/papers/39799156PubMed
39,450,676Zinc signaling controls astrocyte-dependent synapse modulation via the PAF receptor pathway.J Neurochem2025https://conductscience.org/library/papers/39450676PubMed

Genes33

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ARTN9,048PubTator's text mininghttps://conductscience.org/library/genes/9048NCBI Gene
BDNF627PubTator's text mininghttps://conductscience.org/library/genes/627NCBI Gene
CCL206,364PubTator's text mininghttps://conductscience.org/library/genes/6364NCBI Gene
CCR61,235PubTator's text mininghttps://conductscience.org/library/genes/1235NCBI Gene
CRP1,401PubTator's text mininghttps://conductscience.org/library/genes/1401NCBI Gene
CXCL83,576PubTator's text mininghttps://conductscience.org/library/genes/3576NCBI Gene
IFNG3,458PubTator's text mininghttps://conductscience.org/library/genes/3458NCBI Gene
IL103,586PubTator's text mininghttps://conductscience.org/library/genes/3586NCBI Gene
IL12B3,593PubTator's text mininghttps://conductscience.org/library/genes/3593NCBI Gene
IL133,596PubTator's text mininghttps://conductscience.org/library/genes/3596NCBI Gene

1 to 10 of 33

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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