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Paper · 34764255

Generation of functional ciliated cholangiocytes from human pluripotent stem cells.

Ogawa M and 13 others. Nat Commun, 2021. Cited by 39 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Generation of functional ciliated cholangiocytes from human pluripotent stem cells. Papers, record 34764255. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34764255

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Generation of functional ciliated cholangiocytes from human pluripotent stem cells.
PubMed
Journal
Nat Commun
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
39
iCite
Relative citation ratio, by iCite
2.21
iCite
Revised in PubMed
2023-02-08
PubMed

Authors14

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ogawa MMinahttps://orcid.org/0000-0002-9138-4913
2Jiang JXJia-Xin
3Xia SSunny
4Yang DDonghe
5Ding AAvrilynn
6Laselva OOnofrio
7Hernandez MMarcela
8Cui CChangyi
9Higuchi YYuichiro
10Suemizu HHiroshihttps://orcid.org/0000-0002-3706-2454

1 to 10 of 14Source PubMed

See all 14 authors

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Bile Duct DiseasesMajor topic
Cystic Fibrosis Transmembrane Conductance RegulatorMajor topic
Epithelial CellsMajor topic
Pluripotent Stem CellsMajor topic
Cell Differentiation
Developmental Biology
Humans
Induced Pluripotent Stem Cells

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References74

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
130,850,822Cholangiocyte pathobiology.Nat Rev Gastroenterol Hepatol2019https://conductscience.org/library/papers/30850822PubMed
226,579,437Bile acid signaling and biliary functions.Acta Pharm Sin B2015https://conductscience.org/library/papers/26579437PubMed
321,691,098The role of cilia in the regulation of bile flow.Dig Dis2011https://conductscience.org/library/papers/21691098PubMed
428,625,917The cholangiocyte primary cilium in health and disease.Biochim Biophys Acta Mol Basis Dis2018https://conductscience.org/library/papers/28625917PubMed
518,687,752Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors.Am J Physiol Gastrointest Liver Physiol2008https://conductscience.org/library/papers/18687752PubMed
616,952,559Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling.Gastroenterology2006https://conductscience.org/library/papers/16952559PubMed
718,407,555Cholangiocyte primary cilia in liver health and disease.Dev Dyn2008https://conductscience.org/library/papers/18407555PubMed
825,957,621The Cholangiopathies.Mayo Clin Proc2015https://conductscience.org/library/papers/25957621PubMed
931,165,788Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Nat Rev Gastroenterol Hepatol2019https://conductscience.org/library/papers/31165788PubMed
1023,540,507Liver transplant for cholestatic liver diseases.Clin Liver Dis2013https://conductscience.org/library/papers/23540507PubMed

1 to 10 of 74

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Cited by29

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 39 citations.

PMIDTitleJournalYearIn PapersSource
42,869,933Primary cilia: sensors of biliary homeostasis and disease.Nat Rev Gastroenterol Hepatol2026https://conductscience.org/library/papers/42869933PubMed
42,292,522Modeling ischemic-type biliary lesion in vitro using human expandable intrahepatic cholangiocyte organoids.Front Bioeng Biotechnol2026https://conductscience.org/library/papers/42292522PubMed
42,138,192Primary cilia dysfunction: A critical driver of metabolic diseases (Review).Int J Mol Med2026https://conductscience.org/library/papers/42138192PubMed
41,634,045HCMV infection disrupts barrier functions and promotes epithelial-mesenchymal transition in a cholangiocyte organoid model.Nat Commun2026https://conductscience.org/library/papers/41634045PubMed
41,479,645Application of stem cells in the precise diagnosis and treatment of liver diseases.World J Gastroenterol2025https://conductscience.org/library/papers/41479645PubMed
41,471,270Next-Generation Hydrogels for Biliary Organoid Engineering.Pharmaceuticals (Basel)2025https://conductscience.org/library/papers/41471270PubMed
41,409,779Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review.Front Toxicol2025https://conductscience.org/library/papers/41409779PubMed
41,385,584Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation.PLoS Biol2025https://conductscience.org/library/papers/41385584PubMed
41,248,757Spatial patterning strategies for liver tissue engineering: Biofabrication technologies and applications.Adv Drug Deliv Rev2026https://conductscience.org/library/papers/41248757PubMed
41,020,426Effect of 2D and 3D ECM and Biomechanical Cues on Human iPSC-Derived Liver Progenitor Cell Differentiation.Adv Healthc Mater2026https://conductscience.org/library/papers/41020426PubMed

1 to 10 of 29

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Genes51

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ANO155,107PubTator's text mininghttps://conductscience.org/library/genes/55107NCBI Gene
AQP1358PubTator's text mininghttps://conductscience.org/library/genes/358NCBI Gene
ARL13B200,894PubTator's text mininghttps://conductscience.org/library/genes/200894NCBI Gene
BICC180,114PubTator's text mininghttps://conductscience.org/library/genes/80114NCBI Gene
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
CANX821PubTator's text mininghttps://conductscience.org/library/genes/821NCBI Gene
CD24100,133,941PubTator's text mininghttps://conductscience.org/library/genes/100133941NCBI Gene
CDC6990PubTator's text mininghttps://conductscience.org/library/genes/990NCBI Gene
CDK1983PubTator's text mininghttps://conductscience.org/library/genes/983NCBI Gene

1 to 10 of 51

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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